Molecular architecture of tailed double-stranded DNA phages.

Bacteriophage Pub Date : 2014-01-01 Epub Date: 2014-02-21 DOI:10.4161/bact.28281
Andrei Fokine, Michael G Rossmann
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引用次数: 189

Abstract

The tailed double-stranded DNA bacteriophages, or Caudovirales, constitute ~96% of all the known phages. Although these phages come in a great variety of sizes and morphology, their virions are mainly constructed of similar molecular building blocks via similar assembly pathways. Here we review the structure of tailed double-stranded DNA bacteriophages at a molecular level, emphasizing the structural similarity and common evolutionary origin of proteins that constitute these virions.

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尾部双链DNA噬菌体的分子结构。
尾状双链DNA噬菌体(Caudovirales)占所有已知噬菌体的96%。尽管这些噬菌体的大小和形态各不相同,但它们的病毒粒子主要是由相似的分子构建块通过相似的组装途径构建的。本文从分子水平回顾了尾双链DNA噬菌体的结构,强调了构成这些病毒粒子的蛋白质的结构相似性和共同的进化起源。
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