The true story of the “strong and gentle” Acciano's Giant

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2022-04-01 DOI:10.1016/j.ghir.2022.101457
Maria Maddalena Sirufo , Lina Maria Magnanimi , Lia Ginaldi , Massimo De Martinis
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Abstract

This is the story of a giant who lived in Abruzzo 200 years ago. He became a symbol for his people and a strong resilience generator. Gigantism, in the history of humanity has always attracted attention, albeit passing over the centuries from myth, from divinity to the freak phenomenon, the freak of nature that becomes a spectacle to show off. The attraction for understanding the pathophysiological mechanisms underlying gigantism developed by the end of 19th century. Increased levels of growth hormone (GH) or insulin-like growth hormone 1 (IGF1) causes overgrowth in pituitary gigantism. The imposing size of the body, in our imagination, represents strength and health, reason why in our imagination it almost becomes a divine mythical image. The story of the Acciano's Giant represents a cultural heritage that passes from one generation to the next, that contributes in giving a sense of identity and continuity. It provides a link from past to present and to the future. Encourages a sense of identity and responsibility contributing to social cohesion, helping individuals to feel members of one community. A disease, represented by the Giant, has become a symbol capable of bringing the community together and giving it the strength to react to environment, nature and history. This is a lesson that teaches us the sense of community.

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“坚强而温柔”的阿齐亚诺的巨人的真实故事
这是200年前住在阿布鲁佐的一个巨人的故事。他成为了他的人民的象征,一个强大的恢复力发电机。巨人症,在人类历史上一直吸引着人们的注意,尽管经历了几个世纪,从神话,从神性到怪异的现象,自然的怪异,成为炫耀的奇观。对巨人症的病理生理机制的理解是在19世纪末发展起来的。生长激素(GH)或胰岛素样生长激素1 (IGF1)水平升高导致垂体巨人症过度生长。在我们的想象中,雄伟的身躯代表着力量和健康,这就是为什么在我们的想象中,它几乎成为一个神圣的神话形象。阿齐亚诺的《巨人》的故事代表了一种文化遗产,从一代传到下一代,这有助于给人一种认同感和连续性。它提供了从过去到现在和到未来的联系。鼓励认同感和责任感,有助于社会凝聚力,帮助个人感觉自己是一个社区的成员。一种疾病,以巨人为代表,已经成为一种象征,能够将社区团结在一起,并赋予它应对环境、自然和历史的力量。这是教会我们社区意识的一课。
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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