Effects of nutrients on immunomodulation in patients with severe COVID-19: Current knowledge.

世界危重病急救学杂志(英文版) Pub Date : 2022-07-09 DOI:10.5492/wjccm.v11.i4.201

Bruna Teixeira da Costa, Glauber Rocha Lima Araújo, Ronaldo Teixeira da Silva Júnior, Luana Kauany de Sá Santos, Vinícius Lima de Souza Gonçalves, Daniel Bastos Alves Lima, Beatriz Rocha Cuzzuol, Jonathan Santos Apolonio, Lorena Sousa de Carvalho, Hanna Santos Marques, Camilo Santana Silva, Isadora de Souza Barcelos, Márcio Vasconcelos Oliveira, Fabrício Freire de Melo

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Abstract

Recent research has demonstrated that critically ill patients with coronavirus disease 2019 (COVID-19) show significant immune system dysregulation. Due to that, some nutrients that influence immunomodulation have been suggested as a form of treatment against the infection. This review collected the information on the impact of vitamins on the prognosis of COVID-19, with the intention of facilitating treatment and prevention of the disease risk status in patients. The collected information was obtained using the PubMed electronic database by searching for articles that relate COVID-19 and the mechanisms/effects of the nutrients: Proteins, glucose, lipids, vitamin B12, vitamin D, calcium, iron, copper, zinc, and magnesium, including prospective, retrospective, and support articles. The findings reveal an optimal response related mainly to omega-3, eicosapentaenoic acid, docosahexaenoic acid, calcium, and iron that might represent benefits in the treatment of critically ill patients. However, nutrient supplementation should be done with caution due to the limited availability of randomized controlled studies.

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营养物质对重症COVID-19患者免疫调节的影响:目前的知识

最近的研究表明，2019冠状病毒病(COVID-19)危重患者表现出明显的免疫系统失调。因此，一些影响免疫调节的营养物质被认为是对抗感染的一种治疗形式。本综述收集维生素对COVID-19预后影响的信息，旨在促进患者疾病风险状态的治疗和预防。收集的信息是通过PubMed电子数据库检索与COVID-19和营养素的机制/作用相关的文章获得的:蛋白质、葡萄糖、脂质、维生素B12、维生素D、钙、铁、铜、锌和镁，包括前瞻性、回顾性和支持性文章。研究结果揭示了一种主要与omega-3、二十碳五烯酸、二十二碳六烯酸、钙和铁有关的最佳反应，这可能对危重病人的治疗有益。然而，由于随机对照研究的可用性有限，营养补充应谨慎进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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世界危重病急救学杂志(英文版)

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