Cognitive Impairment and Neurodegenerative Diseases Development Associated with Organophosphate Pesticides Exposure: a Review Study.

IF 3.3 3区医学 Q2 NEUROSCIENCES Neurotoxicity Research Pub Date : 2022-10-01 Epub Date: 2022-09-06 DOI:10.1007/s12640-022-00552-0

Mehdi Sarailoo, Salva Afshari, Vahid Asghariazar, Elham Safarzadeh, Masoomeh Dadkhah

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引用次数: 6

Abstract

A significant body of literature emphasizes the role of insecticide, particularly organophosphates (OPs), as the major environmental factor in the etiology of neurodegenerative diseases. This review aims to study the relationship between OP insecticide exposure, cognitive impairment, and neurodegenerative disease development. Human populations, especially in developing countries, are frequently exposed to OPs due to their extensive applications. The involvement of various signaling pathways in OP neurotoxicity are reported, but the OP-induced cognitive impairment and link between OP exposure and the pathophysiology of neurodegenerative diseases are not clearly understood. In the present review, we have therefore aimed to come to new conclusions which may help to find protective and preventive strategies against OP neurotoxicity and may establish a possible link between organophosphate exposure, cognitive impairment, and OP-induced neurotoxicity. Moreover, we discuss the findings obtained from animal and human research providing some support for OP-induced cognitive impairment and neurodegenerative disorders.

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与有机磷农药暴露相关的认知障碍和神经退行性疾病的发展:一项综述研究

大量文献强调杀虫剂的作用，特别是有机磷(OPs)，作为神经退行性疾病病因的主要环境因素。本文旨在研究OP杀虫剂暴露与认知障碍和神经退行性疾病发展之间的关系。人类，特别是发展中国家的人口，由于其广泛应用而经常接触到有机磷化合物。各种信号通路参与了OP神经毒性的报道，但OP诱导的认知障碍以及OP暴露与神经退行性疾病的病理生理之间的联系尚不清楚。因此，在本综述中，我们旨在得出新的结论，这可能有助于找到针对OP神经毒性的保护和预防策略，并可能建立有机磷暴露，认知障碍和OP诱导的神经毒性之间的可能联系。此外，我们讨论了从动物和人类研究中获得的发现，为op诱导的认知障碍和神经退行性疾病提供了一些支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotoxicity Research 医学-神经科学

CiteScore

7.70

自引率

5.40%

发文量

164

审稿时长

6-12 weeks

期刊介绍： Neurotoxicity Research is an international, interdisciplinary broad-based journal for reporting both basic and clinical research on classical neurotoxicity effects and mechanisms associated with neurodegeneration, necrosis, neuronal apoptosis, nerve regeneration, neurotrophin mechanisms, and topics related to these themes. Published papers have focused on: NEURODEGENERATION and INJURY Neuropathologies Neuronal apoptosis Neuronal necrosis Neural death processes (anatomical, histochemical, neurochemical) Neurodegenerative Disorders Neural Effects of Substances of Abuse NERVE REGENERATION and RESPONSES TO INJURY Neural Adaptations Neurotrophin mechanisms and actions NEURO(CYTO)TOXICITY PROCESSES and NEUROPROTECTION Excitatory amino acids Neurotoxins, endogenous and synthetic Reactive oxygen (nitrogen) species Neuroprotection by endogenous and exogenous agents Papers on related themes are welcome.