{"title":"Progesterone and progestogens.","authors":"Joanne Lipinski","doi":"10.18773/austprescr.2022.047","DOIUrl":null,"url":null,"abstract":"I am concerned by the ambiguity about progesterone/progestogen in the article ‘Hormonal contraception and mood disorders’.1 The summary correctly states ‘The link between oral contraceptive pills and depression relates to the amount and type of progestogen contained in these pills’, but the article subsequently says that progesterone can worsen mood symptoms. Plausible links are said to include progesterone augmentation of GABA-induced inhibition of glutamate transmission, and progesterone increasing the concentrations of monoamine oxidase, resulting in decreased serotonin concentrations. However, these links should be referring to progestogen rather than progesterone.","PeriodicalId":55588,"journal":{"name":"Australian Prescriber","volume":"45 4","pages":"115"},"PeriodicalIF":3.4000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/eb/austprescr-45-115.PMC9427621.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australian Prescriber","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18773/austprescr.2022.047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
I am concerned by the ambiguity about progesterone/progestogen in the article ‘Hormonal contraception and mood disorders’.1 The summary correctly states ‘The link between oral contraceptive pills and depression relates to the amount and type of progestogen contained in these pills’, but the article subsequently says that progesterone can worsen mood symptoms. Plausible links are said to include progesterone augmentation of GABA-induced inhibition of glutamate transmission, and progesterone increasing the concentrations of monoamine oxidase, resulting in decreased serotonin concentrations. However, these links should be referring to progestogen rather than progesterone.
期刊介绍：
Australian Prescriber is Australia''s free, national, independent journal of drugs and therapeutics. It is published every two months online.
Our purpose is to help health professionals make informed choices when prescribing, including whether to prescribe a drug or not. To do this we provide independent, reliable and accessible information.
As well as publishing short didactic reviews, we facilitate debate about complex, controversial or uncertain therapeutic areas.
We are part of NPS MedicineWise, an independent, non-profit organisation providing medicines information and resources for health professionals, and stakeholders involved in the quality use of medicines. NPS MedicineWise is funded by the Australian Government Department of Health.
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