Fedor Galkin, Kirill Kochetov, Diana Koldasbayeva, Manuel Faria, Helene H Fung, Amber X Chen, Alex Zhavoronkov
{"title":"Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults.","authors":"Fedor Galkin, Kirill Kochetov, Diana Koldasbayeva, Manuel Faria, Helene H Fung, Amber X Chen, Alex Zhavoronkov","doi":"10.18632/aging.204264","DOIUrl":null,"url":null,"abstract":"<p><p>We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart, liver, and lung conditions. We demonstrate that psychological factors, such as feeling unhappy or being lonely, add up to 1.65 years to one's biological age, and the aggregate effect exceeds the effects of biological sex, living area, marital status, and smoking status. We conclude that the psychological component should not be ignored in aging studies due to its significant impact on biological age.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":" ","pages":"7206-7222"},"PeriodicalIF":4.7000,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550255/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18632/aging.204264","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart, liver, and lung conditions. We demonstrate that psychological factors, such as feeling unhappy or being lonely, add up to 1.65 years to one's biological age, and the aggregate effect exceeds the effects of biological sex, living area, marital status, and smoking status. We conclude that the psychological component should not be ignored in aging studies due to its significant impact on biological age.
我们利用中国健康与退休纵向研究（China Health and Retirement Longitudinal Study）的血液检测数据开发了深度学习老化时钟，其平均绝对误差为 5.68 年。我们利用老化时钟来展示衰老的生理和心理方面之间的联系。该时钟可检测到患有心脏、肝脏和肺部疾病的人的加速衰老。我们证明，心理因素，如感到不快乐或孤独，会使一个人的生理年龄增加 1.65 岁，其综合效应超过生理性别、居住地区、婚姻状况和吸烟状况的影响。我们的结论是，由于心理因素对生理年龄的重大影响，在老龄化研究中不应忽视心理因素。
期刊介绍：
ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric.
Indexed/Abstracted：
Web of Science SCIE
Scopus
CAS
INSPEC
Portico
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
