Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis

IF 7.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Cellular and Molecular Gastroenterology and Hepatology Pub Date : 2022-01-01 DOI:10.1016/j.jcmgh.2022.05.015

Hailey Cuddihey , Wallace K. MacNaughton , Keith A. Sharkey

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引用次数: 10

Abstract

The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants of intestinal homeostasis and are therefore tightly regulated by a variety of signaling mechanisms. The endocannabinoid system is a lipid mediator signaling system widely expressed in the gastrointestinal tract. Accumulating evidence suggests the endocannabinoid system is a critical nexus involved in the physiological processes that underlie the control of intestinal homeostasis. In this review we will illustrate how the endocannabinoid system is involved in regulation of intestinal permeability, fluid secretion, and immune regulation. We will also demonstrate a reciprocal regulation between the endocannabinoid system and the gut microbiome. The role of the endocannabinoid system is complex and multifaceted, responding to both internal and external factors while also serving as an effector system for the maintenance of intestinal homeostasis.

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内源性大麻素系统在肠道稳态调节中的作用

维持肠道内稳态对健康至关重要。肠道屏障功能和免疫调节是肠道内稳态的关键决定因素，因此受到多种信号机制的严格调节。内源性大麻素系统是广泛表达于胃肠道的脂质介质信号系统。越来越多的证据表明，内源性大麻素系统在控制肠道内稳态的生理过程中是一个关键的联系。在这篇综述中，我们将阐述内源性大麻素系统是如何参与调节肠道通透性、液体分泌和免疫调节的。我们还将展示内源性大麻素系统和肠道微生物群之间的相互调节。内源性大麻素系统的作用是复杂和多方面的，既响应内部和外部因素，又作为维持肠道内稳态的效应系统。

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来源期刊

Cellular and Molecular Gastroenterology and Hepatology Medicine-Gastroenterology

CiteScore

13.00

自引率

2.80%

发文量

246

审稿时长

42 days

期刊介绍： "Cell and Molecular Gastroenterology and Hepatology (CMGH)" is a journal dedicated to advancing the understanding of digestive biology through impactful research that spans the spectrum of normal gastrointestinal, hepatic, and pancreatic functions, as well as their pathologies. The journal's mission is to publish high-quality, hypothesis-driven studies that offer mechanistic novelty and are methodologically robust, covering a wide range of themes in gastroenterology, hepatology, and pancreatology. CMGH reports on the latest scientific advances in cell biology, immunology, physiology, microbiology, genetics, and neurobiology related to gastrointestinal, hepatobiliary, and pancreatic health and disease. The research published in CMGH is designed to address significant questions in the field, utilizing a variety of experimental approaches, including in vitro models, patient-derived tissues or cells, and animal models. This multifaceted approach enables the journal to contribute to both fundamental discoveries and their translation into clinical applications, ultimately aiming to improve patient care and treatment outcomes in digestive health.