Dynamic changes of serum cytokines in acute paraquat poisoning and changes in patients' immune function

IF 1.9 4区 生物学 Q4 CELL BIOLOGY IET Systems Biology Pub Date : 2022-06-27 DOI:10.1049/syb2.12045
Huimin Yuan, Qian Liu, Yulan Yu
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Abstract

Acute paraquat poisoning is due to the extremely severe toxicity of paraquat. After paraquat enters the human body, it will cause rapid changes in the human body system. Since paraquat poisoning will quickly invade the organs of the whole body, it may cause damage to the functions of multiple organs in the poisoned patient. The liver organ is the most important detoxification site for the human body, so the damage to the liver of the patient is more obvious. This article discovers and observes the structure of paraquat and the dynamic changes of serum cytokines in patients with paraquat poisoning through the clinical phenomenon of paraquat poisoning, and the related changes of human serum cells after the subjects took paraquat and the changes of cell dynamic factors after different doses of paraquat entered the human body were analysed. At the same time, the changes in the immune function of the body of different groups of people were also observed. The experimental results in this article show that according to the intake of paraquat, the severity of poisoning patients will be mild, moderate, severe and outbreak poisoning. Among them, the dose for adults who cannot be treated for prognosis is 10 ml.

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急性百草枯中毒患者血清细胞因子的动态变化及免疫功能的变化
急性百草枯中毒是由于百草枯的毒性极其严重。百草枯进入人体后,会引起人体系统的快速变化。由于百草枯中毒会迅速侵入全身脏器,可能对中毒患者的多脏器功能造成损害。肝器官是人体最重要的排毒部位,因此对患者肝脏的损害更为明显。本文通过百草枯中毒的临床现象,发现并观察了百草枯中毒患者体内的百草枯结构和血清细胞因子的动态变化,并分析了受试者服用百草枯后人体血清细胞的相关变化以及不同剂量的百草枯进入人体后细胞动态因子的变化。同时,还观察了不同人群机体免疫功能的变化。本文的实验结果表明,根据百草枯的摄入量,中毒患者的严重程度将分为轻度、中度、重度和暴发中毒。其中,不能治疗预后的成人剂量为10ml。
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来源期刊
IET Systems Biology
IET Systems Biology 生物-数学与计算生物学
CiteScore
4.20
自引率
4.30%
发文量
17
审稿时长
>12 weeks
期刊介绍: IET Systems Biology covers intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. Papers that analyse genomic data in order to identify variables and basic relationships between them are considered if the results provide a basis for mathematical modelling and simulation of cellular dynamics. Manuscripts on molecular and cell biological studies are encouraged if the aim is a systems approach to dynamic interactions within and between cells. The scope includes the following topics: Genomics, transcriptomics, proteomics, metabolomics, cells, tissue and the physiome; molecular and cellular interaction, gene, cell and protein function; networks and pathways; metabolism and cell signalling; dynamics, regulation and control; systems, signals, and information; experimental data analysis; mathematical modelling, simulation and theoretical analysis; biological modelling, simulation, prediction and control; methodologies, databases, tools and algorithms for modelling and simulation; modelling, analysis and control of biological networks; synthetic biology and bioengineering based on systems biology.
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