The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.

Q3 Veterinary Case Reports in Veterinary Medicine Pub Date : 2022-08-02 eCollection Date: 2022-01-01 DOI:10.1155/2022/2747108

Harry J Gould, Samantha Edenfield, Paige R Miller, Kelly Jean Sherman, Brian Melius, Alissa Whitney, Robert P Hunter, Fabio Del Piero, Dennis Tracey, Dennis Paul

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引用次数: 1

Abstract

Background: Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na⁺, K⁺-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating advanced carcinomas in companion animals. Animals. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.

Methods: Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.

Results: Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. Conclusions and Clinical Importance. TOL warrants consideration as an option for managing advanced carcinomas.

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靶向渗透裂解在伴侣动物晚期癌治疗中的作用:一个病例系列。

背景:靶向渗透裂解(Targeted osmotic lysis, TOL)是一项新技术，涉及到同时刺激电压门控钠通道(VGSCs)和药物阻断Na+， K+- atp酶导致高度恶性癌细胞的裂解。假设/目标。TOL为治疗伴侣动物的晚期癌症提供了一种选择。动物。两只猫和两只狗被送到兽医医院接受评估和治疗几种癌症中的一种。方法:给药地高辛达到稳态治疗浓度。然后，这些动物受到脉冲电场刺激。比较治疗前后肿瘤大小和生活质量的评估。治疗频率和存活率根据患者的发病前功能和对治疗的反应而变化。结果:无论癌症类型如何，TOL持续提高生存率，超出预期，通常改善，但不影响生活质量。结论及临床意义。TOL值得考虑作为一种治疗晚期癌的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Veterinary Medicine Veterinary-Veterinary (all)

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Case Reports in Veterinary Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series in all areas of veterinary medicine.