SINGLE-CHANNEL ION CURRENTS IN THE NUCLEAR ENVELOPE OF RAT CARDIOMYOCYTES.

O A Kotyk, A B Kotliarova, A O Polishchuk, S M Marchenko
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引用次数: 4

Abstract

Using the patch clamp technique in nucleus attached configuration we have found that the nuclear membrane of rat cardiomyocytes contains different types of ion channels with conductances in the range from 10 to 400 pS. In particular, we recorded inositol 1,4,5-trisphosphate receptors with conductance of 384 ± 5 pS and 209 ± 13 pS cation channels similar to LCC-channels, previously reported in neurons. In addition, we found at least two types of ion channels with significantly higher conductance than that of LCC-channels and several types of ion channels with lower conductance (10-90 pS).

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大鼠心肌细胞核膜内的单通道离子电流。
利用膜片钳技术,我们发现大鼠心肌细胞核膜中含有不同类型的离子通道,其电导范围在10到400 pS之间。特别是,我们记录了肌醇1,4,5-三磷酸受体,其电导为384±5 pS和209±13 pS,与之前在神经元中报道的lcc通道相似。此外,我们发现至少有两种类型的离子通道的电导明显高于lc -通道,以及几种类型的离子通道的电导较低(10-90 pS)。
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