ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.4103/0304-4920.359795

Jihu Zheng, Zijian Guo, Zhanchao Wen, Huikang Chen

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Abstract

Hepatocellular carcinoma is a common malignant tumor with high recurrence rate. Long non-coding RNA (lncRNA) ZNF561 antisense RNA 1 (ZNF561-AS1) functions as an oncogenic lncRNA to promote the tumorigenesis of colorectal cancer. The role of ZNF561-AS1 in hepatocellular carcinoma remains unknown. ZNF561-AS1 was elevated in hepatocellular carcinoma tissues and cells. Silence of ZNF561-AS1 reduced cell viability and inhibited the proliferation of hepatocellular carcinoma. The angiogenesis of hepatocellular carcinoma was also suppressed by loss of ZNF561-AS1 with a decrease of angiopoietin 2, fibroblast growth factor 1, and vascular endothelial growth factor. ZNF561-AS1 bind to miR-302a-3p, and decreased expression of miR-302a-3p in hepatocellular carcinoma. Moreover, miR-302a-3p reduced platelet-derived growth factor-D (PDGFD) in hepatocellular carcinoma, and inhibition of miR-302a-3p attenuated ZNF561-AS1 silence-induced decrease of PDGFD. In conclusion, silence of ZNF561-AS1 might inhibit cell proliferation and angiogenesis of hepatocellular carcinoma through downregulation of miR-302a-3p-mediated PDGFD.

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ZNF561反义RNA 1通过上调血小板源性生长因子d参与肝细胞癌血管生成。

肝细胞癌是一种常见的恶性肿瘤，复发率高。长链非编码RNA (lncRNA) ZNF561反义RNA 1 (ZNF561- as1)作为一种致癌lncRNA促进结直肠癌的肿瘤发生。ZNF561-AS1在肝细胞癌中的作用尚不清楚。ZNF561-AS1在肝细胞癌组织和细胞中表达升高。沉默ZNF561-AS1可降低肝癌细胞活力，抑制肝癌细胞增殖。肝细胞癌的血管生成也被ZNF561-AS1的缺失所抑制，同时血管生成素2、成纤维细胞生长因子1和血管内皮生长因子的降低。ZNF561-AS1结合miR-302a-3p，降低miR-302a-3p在肝细胞癌中的表达。此外，miR-302a-3p可降低肝细胞癌中的血小板衍生生长因子d (PDGFD)，抑制miR-302a-3p可减弱ZNF561-AS1沉默诱导的PDGFD的降低。综上所述，ZNF561-AS1的沉默可能通过下调mir -302a-3p介导的PDGFD来抑制肝癌细胞增殖和血管生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.