Clinicopathologic characteristics of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma: a case report.

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Haoyue Hu, Lang Long, Xue Fan, Jun He

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Abstract

Low-grade thyroid-like nasopharyngeal papillary adenocarcinoma is a rare malignant tumor characterized by morphologic analogy to papillary thyroid carcinoma and aberrant thyroid transcription factor-1 (TTF-1) expression. To date, a limited number of cases have been reported in the literature. We report a case of a 20-year-old Chinese male patient with complaints of headaches and nosebleeds for 5 months. The histopathologic examination showed thyroid-like low-grade nasopharyngeal papillary adenocarcinoma that was confirmed by immunohistochemical staining. The patient was treated with macroscopic complete resection without adjuvant therapy. The epidemiologic characteristics and clinical and pathologic features of the disease are summarized. In addition, we summarize the treatments used previously. In general, TL-LGNPPA is a very rare low-grade adenocarcinoma with aberrant expression of TTF-1, and its diagnosis depends on morphology and immunophenotype. The prognosis is good.

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低级别甲状腺样鼻咽乳头状腺癌的临床病理特征1例。

低级别甲状腺样鼻咽乳头状腺癌是一种罕见的恶性肿瘤，其形态学与甲状腺乳头状癌相似，且甲状腺转录因子-1 (TTF-1)表达异常。迄今为止，文献中报告的病例数量有限。我们报告一例20岁的中国男性患者，主诉头痛和流鼻血5个月。组织病理检查为甲状腺样低级别鼻咽乳头状腺癌，经免疫组化染色证实。患者行肉眼全切除，无辅助治疗。总结了该病的流行病学特点和临床病理特点。此外，我们总结了以前使用的处理方法。总的来说，TL-LGNPPA是一种非常罕见的TTF-1异常表达的低级别腺癌，其诊断依赖于形态学和免疫表型。预后良好。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.