Neck of the woods: Microbes, memory, and resistance

Pub Date : 2022-03-01 DOI:10.1016/j.endeavour.2022.100821
Adam Dickinson
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引用次数: 1

Abstract

Horizontal Gene Transfer (HGT) is a key mechanism allowing bacteria to enact genetic changes in response to shifting environmental conditions. The swift lateral movement of genes makes possible antibiotic resistance, which is an increasing medical and ultimately cultural problem. There is evidence that HGT also takes place between species. Bacterial DNA appears in the human mitochondrial genome of acute myeloid leukemia (AML) samples. Responding to a recent diagnosis of AML, this creative piece imagines a literary form of HGT. Adjacency is intrinsic to the conceptual and formal concerns of the text. Moving back and forth between essay and poem, between the personal and the planetary, between the real and the imagined, and between the right and left margins of the page, this piece unfolds beside itself, exploring the lateral movement of memory and family history through concerns with antibiotic resistance, illness, writing, and science. While there are no embedded citations or footnotes, a glossary of terms (Appendix 1) follows the main text, and a brief bibliographic essay (Appendix 2) at the end identifies cited sources that correspond to a list of references.

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关键问题:微生物、记忆和耐药性
水平基因转移(HGT)是一种关键的机制,允许细菌制定遗传变化,以应对不断变化的环境条件。基因的快速横向移动使抗生素耐药性成为可能,这是一个日益严重的医学问题,最终成为文化问题。有证据表明,物种之间也会发生HGT。细菌DNA出现在急性髓性白血病(AML)样本的人类线粒体基因组中。针对最近的AML诊断,这篇创造性的作品想象了一种文学形式的HGT。邻接性是文本概念和形式关注的内在因素。在散文和诗歌之间,在个人和星球之间,在真实和想象之间,在页面的左右边缘之间来回移动,这件作品展现了自我,通过对抗生素耐药性,疾病,写作和科学的关注来探索记忆和家族史的横向运动。虽然没有嵌入引用或脚注,但主要文本后面有术语表(附录1),最后有一个简短的参考书目(附录2),确定了与参考文献列表对应的引用来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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