Effect of altered human exposome on the skin and mucosal epithelial barrier integrity.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Tissue Barriers Pub Date : 2023-10-02 Epub Date: 2022-10-19 DOI:10.1080/21688370.2022.2133877

Yagiz Pat, Ismail Ogulur, Duygu Yazici, Yasutaka Mitamura, Lacin Cevhertas, Ozan C Küçükkase, Sanne S Mesisser, Mübeccel Akdis, Kari Nadeau, Cezmi A Akdis

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引用次数: 9

Abstract

Pollution in the world and exposure of humans and nature to toxic substances is continuously worsening at a rapid pace. In the last 60 years, human and domestic animal health has been challenged by continuous exposure to toxic substances and pollutants because of uncontrolled growth, modernization, and industrialization. More than 350,000 new chemicals have been introduced to our lives, mostly without any reasonable control of their health effects and toxicity. A plethora of studies show exposure to these harmful substances during this period with their implications on the skin and mucosal epithelial barrier and increasing prevalence of allergic and autoimmune diseases in the context of the "epithelial barrier hypothesis". Exposure to these substances causes an epithelial injury with peri-epithelial inflammation, microbial dysbiosis and bacterial translocation to sub-epithelial areas, and immune response to dysbiotic bacteria. Here, we provide scientific evidence on the altered human exposome and its impact on epithelial barriers.

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改变人体暴露对皮肤和粘膜上皮屏障完整性的影响。

世界上的污染以及人类和大自然接触有毒物质的情况正在迅速恶化。在过去的60年里，由于不受控制的增长、现代化和工业化，人类和家畜的健康一直受到有毒物质和污染物的持续暴露的挑战。超过350000种新的化学物质被引入我们的生活，大多数都没有对其健康影响和毒性进行任何合理的控制。大量研究表明，在此期间接触这些有害物质对皮肤和粘膜上皮屏障的影响，以及在“上皮屏障假说”的背景下过敏性和自身免疫性疾病的发病率增加。暴露于这些物质会导致上皮损伤，包括上皮周围炎症、微生物失调和细菌移位到上皮下区域，以及对失调细菌的免疫反应。在这里，我们提供了关于人类暴露组改变及其对上皮屏障影响的科学证据。

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.