Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer's Disease Biomarkers.

IF 3.2 2区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Psicothema Pub Date : 2022-11-01 DOI:10.7334/psicothema2022.103

Inés Ferrer-Cairols, Teresa Montoliu, Isabel Crespo-Sanmiguel, Matias M Pulopulos, Vanesa Hidalgo, Enriqueta Gómez, Rogelio López-Cuevas, Ana Cuevas, Núria Martín, Miguel Baquero, Alicia Salvador

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引用次数: 2

Abstract

Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer's Disease (AD) could help to clarify the role of depression and SI in AD.

Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed.

Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide.

Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms.

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轻度认知障碍患者的抑郁和自杀风险:阿尔茨海默病生物标志物的作用

背景:患有抑郁症和轻度认知障碍(MCI)的患者发生痴呆的风险更高。抑郁症涉及更高的自杀意念(SI)和自杀企图(SA)的风险。阿尔茨海默病(AD)的生物标志物可以帮助阐明抑郁症和SI在AD中的作用。方法:对59名年龄> 50岁，MCI阳性(MCI-AD) (n=22)和MCI阴性(MCI- non -AD) (n=24)和健康对照组(HC) (n=13)进行评价。我们分别使用老年抑郁量表(GDS-30)和GDS-SI因子来测量抑郁和间接自杀风险。此外，还分析了AD生物标志物，如脑脊液(CSF)中的淀粉样蛋白- β (asβ)、过度磷酸化tau (P-tau)和总tau (T-tau)。结果:两组患者抑郁程度无显著差异。然而，在MCI-AD组中，较低的P-tau和T-tau水平与较高的GDS-SI评分相关，这表明具有较低AD病理的MCI-AD患者自杀风险较高。结论:该结果强调了在阿尔茨海默病初期考虑SI的重要性，以及阿尔茨海默病生物标志物在早期症状检测中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psicothema PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

6.50

自引率

16.70%

发文量

审稿时长

24 weeks

期刊介绍： La revista Psicothema fue fundada en Asturias en 1989 y está editada conjuntamente por la Facultad y el Departamento de Psicología de la Universidad de Oviedo y el Colegio Oficial de Psicólogos del Principado de Asturias. Publica cuatro números al año. Se admiten trabajos tanto de investigación básica como aplicada, pertenecientes a cualquier ámbito de la Psicología, que previamente a su publicación son evaluados anónimamente por revisores externos. Psicothema está incluida en las bases de datos nacionales e internacionales más relevantes, entre las que cabe destacar Psychological Abstracts, Current Contents y MEDLINE/Index Medicus, entre otras. Además, figura en las listas de Factor de Impacto del Journal Citation Reports. Psicothema es una revista abierta a cualquier enfoque u orientación psicológica que venga avalada por la fuerza de los datos y los argumentos, y en la que encuentran acomodo todos los autores que sean capaces de convencer a los revisores de que sus manuscritos tienen la calidad para ser publicados. Psicothema es una revista de acceso abierto lo que significa que todo el contenido está a disposición de cualquier usuario o institución sin cargo alguno. Los usuarios pueden leer, descargar, copiar, distribuir, imprimir, buscar, o realizar enlaces a los textos completos de esta revista sin pedir permiso previo al editor o al autor, siempre y cuando la fuente original sea referenciada. Para acervos y repositorios, se prefiere que la cobertura se realice mediante enlaces a la propia web de Psicothema. Nos parece que una apuesta decidida por la calidad es el mejor modo de servir a nuestros lectores, cuyas sugerencias siempre serán bienvenidas.