Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2022-06-15 eCollection Date: 2022-01-01

Ling-Min Liao, Zhen-Bang Gu, Ming Fang, Gong-Ji Yao, Long Huang

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Abstract

Background: Cervical small cell carcinoma (SCCC) is uncommon and little is known about its molecular markers. Karyopherin α2 (KPNA2) has been demonstrated in a variety of malignancies. Our objective was to determine whether the KPNA2 level is predictive of clinical outcome in patients with SCCC.

Methods: We detected KPNA2 expression by immunohistochemistry in SCCC tumors from 62 patients. The staining results were evaluated by H-score. The correlation among KPNA2 expression level, clinical characteristics, and prognosis was analyzed.

Results: KPNA2 expression was detected in tumor tissue from 55 patients with SCCC (55/62, 89%). High KPNA2 expression correlated significantly with International Federation of Gynecology and Obstetrics staging (P=0.035), tumor size (P=0.019), poorer overall survival (OS) (P=0.008), and poorer disease-free survival (P=0.004) compared to low KPNA2 expression. Multivariate analysis showed that KPNA2 expression level (P=0.037) and tumor size (P=0.046) were independent prognostic factors of OS.

Conclusions: KPNA2 may be a molecular marker and indicator of prognosis in SCCC.

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核粘蛋白α2在宫颈小细胞癌中的过表达与预后不良相关。

背景:宫颈小细胞癌(SCCC)是一种罕见的疾病，对其分子标志物知之甚少。核柔蛋白α2 (KPNA2)已在多种恶性肿瘤中得到证实。我们的目的是确定KPNA2水平是否能预测SCCC患者的临床结果。方法:采用免疫组化方法检测62例SCCC肿瘤组织中KPNA2的表达。H-score评价染色结果。分析KPNA2表达水平与临床特征及预后的相关性。结果:55例SCCC患者的肿瘤组织中检测到KPNA2的表达(55/62,89%)。与低KPNA2表达相比，高KPNA2表达与国际妇产联合会分期(P=0.035)、肿瘤大小(P=0.019)、总生存期(P=0.008)和无病生存期(P=0.004)显著相关。多因素分析显示，KPNA2表达水平(P=0.037)和肿瘤大小(P=0.046)是影响OS预后的独立因素。结论:KPNA2可能是小细胞癌的分子标志物和预后指标。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.