Regulation of mi-RNAs Target Cancer Genes Between Exercise and Non-exercise in Rat Rheumatoid Arthritis Induction: Pilot Study.

IF 3.2 Q2 GENETICS & HEREDITY Epigenetics Insights Pub Date : 2022-06-29 eCollection Date: 2022-01-01 DOI:10.1177/25168657221110485

Vimolmas Tansathitaya, Witchana Sarasin, Tanapati Phakham, Vorthon Sawaswong, Prangwalai Chanchaem, Sunchai Payungporn

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引用次数: 1

Abstract

Introduction: Rheumatoid arthritis is associated with various cancers. Many studies have investigated physical exercise interventions as health improvements to ameliorate the risk of cancer during rheumatoid arthritis diagnosis. Recently, microRNAs were used as biomarkers for health assessment and cancer prediction in rheumatoid arthritis patients.

Methods: The effects of exercise interventions on serum microRNAs were investigated in pristane-induced arthritis (PIA) rat models. Twelve Sprague-Dawley male rats were divided into 4 groups including non-exercise without PIA (N-EX), non-exercise with PIA (N-EX + PIA), exercise without PIA (EX) and exercise with PIA (EX + PIA). Blood samples were collected at the end of the study period to analyze miRNA biomarkers and target cancer gene predictions.

Results: Four significant Rattus norvegicus (rno-microRNAs) may purpose as tumor suppressors were identified as potential target cancer gene candidate expressions within the 4 comparative interventional exercise groups. One rno-microRNA and target cancer gene candidate was up-regulated and 3 rno-microRNAs and their target cancer genes were down-regulated.

Conclusions: Exercise interventions affected rno-miRNAs regulated target cancer gene candidates ITPR3, SOCS6, ITGA6, and NKX2-1 as biomarkers for cancer prognosis in rheumatoid arthritis diagnosis.

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运动与非运动诱导大鼠类风湿关节炎中mir - rnas靶癌基因调控的初步研究

类风湿关节炎与多种癌症有关。许多研究已经调查了体育锻炼干预作为健康改善，以改善类风湿关节炎诊断期间的癌症风险。最近，microrna被用作类风湿关节炎患者健康评估和癌症预测的生物标志物。方法:观察运动干预对前列腺素性关节炎(PIA)大鼠模型血清microrna的影响。将12只雄性Sprague-Dawley大鼠分为非运动无PIA组(N-EX)、非运动有PIA组(N-EX + PIA)、运动无PIA组(EX)和运动有PIA组(EX + PIA)。在研究期结束时收集血液样本，分析miRNA生物标志物和目标癌症基因预测。结果:在4个对比性介入运动组中，4个显著的褐家鼠(rno-microRNAs)可能作为肿瘤抑制因子被鉴定为潜在的靶癌基因候选表达。1个rno-microRNA及其靶癌基因候选基因上调，3个rno-microRNA及其靶癌基因下调。结论:运动干预影响了rno-miRNAs调控的靶癌候选基因ITPR3、SOCS6、ITGA6和NKX2-1作为类风湿关节炎诊断中癌症预后的生物标志物。

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