Profile of Male Breast Cancer in Makkah Region of Saudi Arabia: A 4-Year Retrospective Analysis of Radiology and Histopathology.

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2022-06-22 eCollection Date: 2022-01-01 DOI:10.1155/2022/8831011
Muhammad Saeed, Bothaina Mohammed Abdulshakour, Najwa Abdalkabeer A Bantan, Afnan Hisham Falemban, Munir Abdulla, Ehab M Melibary, Ahmad H Mufti, Mohiuddin M Taher
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Abstract

Background: Mammography is a method widely used for the diagnosis of breast disorders in women and may help detect breast cancer in its early stages. Male breast cancer often remains undiagnosed or is poorly controlled until serious complications arise; therefore, the use of screening methods is needed to help with early diagnosis.

Methods: From a total of 1,667 registered mammography cases screened, 17 male breast disease cases were included in this study. Mammography and ultrasound data were analyzed by Statistical Package of Social Sciences v.22 (SPSS). Diagnosis was made following biopsy in suspicious cases, and histopathological and immunological findings of all such patients were obtained for final diagnosis.

Results: The mean age of the patients was 35 years (range, 14-70 years); 17.6% of the cases were aged 37 yrs, and 2 cases were aged 51 and 52 yrs. Of the 17 cases, 11 had breast lesions, and skin thickening was observed in only 1 case. The different patterns of lesions detected were asymmetry of the parenchyma, mastitis, and hamartoma (n = 1 each), malignant lesions (n = 2), and gynecomastia (n = 6). According to the BI-RADS categorization, 8 cases were benign, one case was probably benign, and 2 cases were likely malignant. In the 2 cases with malignant lesions, pathological diagnosis was made after hematoxylin and eosin and immunocytochemistry examination as invasive ductal carcinoma (IDC) of no special type (NST), grade II and grade III.

Conclusions: Most breast lesions in this study population were benign, while IDC was the most common malignancy encountered. Mammography is currently the most accurate and cost-effective method for detecting breast lesions. The findings of our study may help increase awareness of male breast cancer and encourage Saudi men at risk to perform self-breast exam and undergo routine breast screening.

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沙特阿拉伯麦加地区男性乳腺癌概况:4年放射学和组织病理学回顾性分析。
背景:乳房x光检查是一种广泛用于女性乳腺疾病诊断的方法,可能有助于在早期发现乳腺癌。男性乳腺癌在出现严重并发症之前往往无法确诊或控制不良;因此,需要使用筛查方法来帮助早期诊断。方法:从1,667例登记的乳房x光检查病例中筛选出17例男性乳腺疾病病例。乳房x光检查和超声波数据使用社会科学统计软件包v.22进行分析(SPSS)。可疑病例活检后诊断,并获得所有此类患者的组织病理学和免疫学结果以最终诊断。结果:患者平均年龄35岁(14 ~ 70岁);37岁占17.6%,51岁和52岁占2例。17例中11例有乳腺病变,仅有1例皮肤增厚。不同类型病变分别为实质不对称、乳腺炎、错构瘤各1例,恶性病变2例,男性乳房发育6例。根据BI-RADS分类,良性8例,可能良性1例,可能恶性2例。2例恶性病变,经苏木精、伊红及免疫细胞化学检查病理诊断为浸润性导管癌(invasive ductal carcinoma, IDC),无特殊类型(NST), II级和III级。结论:本研究人群中大多数乳腺病变为良性,而IDC是最常见的恶性肿瘤。乳房x光检查是目前检测乳腺病变最准确、最经济的方法。我们的研究结果可能有助于提高对男性乳腺癌的认识,并鼓励有风险的沙特男性进行自我乳房检查和常规乳房筛查。
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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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