Comparison of the Anti-Obesity Effect of Enriched Capsanthin and Capsaicin from Capsicum annuum L. Fruit in Obesity-Induced C57BL/6J Mouse Model.

IF 2.3 4区 农林科学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Food Technology and Biotechnology Pub Date : 2022-06-01 DOI:10.17113/ftb.60.02.22.7376
Velmurugan Shanmugham, Ravi Subban
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Abstract

Research background: Obesity increases mortality and morbidity due to its impact on type 2 diabetes, cardiovascular and gastrointestinal diseases, arthritis and certain cancers. The epidemic of excessive mass and obesity require constant research to improve therapies without undesirable side effects. Therefore, exploring the anti-obesity phytochemicals from food sources is essential. Most pharmacological studies of the anti-obesity potential of Capsicum annuum have been directed towards capsaicin and very few towards capsanthin. However, these studies utilized uncoated capsaicin and capsanthin. This study aims to compare the anti-obesity effects of enteric-coated capsaicin and capsanthin in a high-fat diet-induced obesity in animal model.

Experimental approach: In this study, we investigated the anti-obesity properties of capsanthin-enriched pellets and capsaicin pellets derived from red chili fruit (Capsicum annuum) on high-fat diet (HFD)-induced obesity in C57BL/6J mice. First, the animals received HFD to induce their obesity. Animals were supplemented orally with pellets. The food intake, body mass, obesity and clinical biomarkers were assessed.

Results and conclusions: The mice fed with HFD gained body mass and white adipose tissue mass compared to the mice that consumed a normal diet. The oral administration of capsanthin-enriched pellets and capsaicin pellets significantly reduced the body mass gain. These pellets have a statistically significant (p<0.05) impact on obesity biomarkers by increasing adiponectin and decreasing leptin, free fatty acid and insulin concentrations relative to HFD control. There was no change in the liver mass in all groups, but there was a significant decrease in white adipose tissue amounts. Inguinal adipose tissue amount was reduced by 37.0% and that of epididymal adipose tissue by 43.64% after treatment with capsanthin-enriched pellets. These results suggest that capsanthin-enriched pellets and capsaicin pellets may be useful in combating metabolic diseases, including obesity, without adverse effects.

Novelty and scientific contribution: We increased the content of capsanthin for more than 50% in capsanthin-enriched extract and extended the room temperature stability for more than one year by converting the crystals into capsanthin-enriched pellets. This study breaks new ground by examining the potential of capsanthin >50% in the management of obesity for the first time.

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比较富含辣椒素和辣椒碱的辣椒果实对肥胖诱导的 C57BL/6J 小鼠模型的抗肥胖作用
研究背景:肥胖症会影响 2 型糖尿病、心血管疾病、胃肠道疾病、关节炎和某些癌症,从而增加死亡率和发病率。过度肥胖的流行需要不断研究,以改进治疗方法,避免不良副作用。因此,探索食物来源中的抗肥胖植物化学物质至关重要。有关辣椒抗肥胖潜力的药理学研究大多针对辣椒素,而针对辣椒素的研究则很少。不过,这些研究使用的都是未包衣的辣椒素和辣椒黄素。本研究旨在比较肠溶辣椒素和辣椒素在高脂饮食诱导的肥胖动物模型中的抗肥胖作用:在本研究中,我们研究了富含辣椒素的颗粒和从红辣椒果实(Capsicum annuum)中提取的辣椒素颗粒对高脂饮食(HFD)诱导的C57BL/6J小鼠肥胖的抗肥胖特性。首先,动物接受高脂饮食诱导肥胖。动物口服补充颗粒食物。结果和结论:结果和结论:与摄入正常饮食的小鼠相比,摄入高纤维食物的小鼠增加了体重和白色脂肪组织质量。口服富含辣椒素的颗粒和辣椒素颗粒可显著减少体重增加。这些颗粒具有显著的统计学意义(p新颖性和科学贡献:通过将晶体转化为富含辣椒素的颗粒,我们提高了富含辣椒素提取物中辣椒素的含量50%以上,并将室温稳定性延长了一年以上。这项研究首次突破性地研究了毛花苷含量>50%在肥胖症治疗中的潜力。
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来源期刊
Food Technology and Biotechnology
Food Technology and Biotechnology 工程技术-生物工程与应用微生物
CiteScore
3.70
自引率
0.00%
发文量
33
审稿时长
12 months
期刊介绍: Food Technology and Biotechnology (FTB) is a diamond open access, peer-reviewed international quarterly scientific journal that publishes papers covering a wide range of topics, including molecular biology, genetic engineering, biochemistry, microbiology, biochemical engineering and biotechnological processing, food science, analysis of food ingredients and final products, food processing and technology, oenology and waste treatment. The Journal is published by the University of Zagreb, Faculty of Food Technology and Biotechnology, Croatia. It is an official journal of Croatian Society of Biotechnology and Slovenian Microbiological Society, financed by the Croatian Ministry of Science and Education, and supported by the Croatian Academy of Sciences and Arts.
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