Impact of anti-thyroid peroxidase and anti-thyroglobulin antibodies on the gestational outcome of euthyroid pregnancies: A retrospective study.

Q3 Medicine Human Antibodies Pub Date : 2022-01-01 DOI:10.3233/HAB-220010

Kemal Beksac, Hanife Guler Donmez, Murat Cagan, Mehmet Sinan Beksac

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Abstract

Background: Thyroglobulin (anti-TG) and/or thyroid peroxidase (anti-TPO) autoantibodies are associated with higher rates of poor gestational outcomes.

Objective: To demonstrate the impact of anti-TPO and anti-TG autoantibodies on the gestational outcomes of euthyroid pregnant women with a history of poor gestational outcome and thyroid gland disorders.

Methods: This retrospective study included totally 75 euthyroid pregnant, 30 of women with high thyroid autoantibodies (Anti-TPO/Thyroglobulin-positive group) and 45 of them without autoantibodies (control group).

Results: We could not demonstrate significant differences between two groups in terms of risk factors/co-morbidities, obstetric complications, gestational outcomes, and birth data (p> 0.05). However, enhanced miscarriage rates were observed among the Anti-TPO/Thyroglobulin-positive and control groups without significance (36.7% and 17.8% respectively, p= 0.116). High neonatal intensive care unit (NICU) admission rates were found for control and Anti-TPO/Thyroglobulin-positive groups (16.2% and 21.1%, respectively) (p= 0.720). Clinically, we compared the two groups in terms of the existence and the types of goiter (diffuse and nodular), and demonstrated that nodular goiter was statistically more frequent in the control group (40.0% vs. 8.7%, p= 0.015). Alongside, relatively high hereditary thrombophilia and type-2 diabetes mellitus rates were found in the Anti-TPO/Thyroglobulin-positive group (20.0% and 20.0%).

Conclusion: Thyroid autoantibody positivity is likely a risk factor for early pregnancy loss and NICU admission.

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抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体对甲状腺功能正常妊娠结局的影响:一项回顾性研究。

背景:甲状腺球蛋白(抗tg)和/或甲状腺过氧化物酶(抗tpo)自身抗体与妊娠结局不良的高发率相关。目的:探讨抗tpo和抗tg自身抗体对有不良妊娠结局和甲状腺疾病史的甲状腺功能正常孕妇妊娠结局的影响。方法:回顾性研究75例甲状腺功能正常的孕妇，其中甲状腺自身抗体高的孕妇30例(抗tpo /甲状腺球蛋白阳性组)，无自身抗体的孕妇45例(对照组)。结果:我们无法证明两组在危险因素/合并症、产科并发症、妊娠结局和出生数据方面存在显著差异(p> 0.05)。抗tpo /甲状腺球蛋白阳性组与对照组流产率增高，差异无统计学意义(分别为36.7%和17.8%，p= 0.116)。对照组和抗tpo /甲状腺球蛋白阳性组新生儿重症监护病房(NICU)入院率较高(分别为16.2%和21.1%)(p= 0.720)。临床比较两组甲状腺肿的存在及类型(弥漫性和结节性)，发现对照组结节性甲状腺肿发生率更高(40.0%比8.7%，p= 0.015)。此外，抗tpo /甲状腺球蛋白阳性组的遗传性血栓病和2型糖尿病发生率相对较高(20.0%和20.0%)。结论:甲状腺自身抗体阳性可能是早期妊娠流产和新生儿重症监护病房住院的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.