Grafting of Natural Polymers and Gums for Drug Delivery Applications: A Perspective Review.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2022035905

Baburao N Chandakavathe, Ravindra G Kulkarni, Shivsharan B Dhadde

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引用次数: 3

Abstract

Natural polymers have received more attention because of their advantages over synthetic polymers such as abundant availability, low cost, biodegradability and non-toxicity. However, natural polymers suffer some limitations such as drop-in viscosity upon storage, uncontrolled hydration, solubility, inability to perform under high temperature and pressure (thermal stability), etc. In many instances above mentioned drawbacks of natural polymers limits their applications in drug delivery systems. Grafting of natural polymer leads to improved properties and characteristics of backbones of macromolecules such as improvement in gel strength, swelling index, mucoadhesion, drug targeting and drug release profile. Therefore, in recent decades grafting of the natural polymer has gained immense importance for the development of drug delivery systems. In addition to the pharmaceutical applications graft copolymers are extensively utilized in diversified fields. The present review is an attempt to define the grafting, various methods of polymer grafting and their application in drug delivery.

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天然聚合物和树胶接枝在药物传递应用中的研究进展。

天然聚合物因其相对于合成聚合物具有可利用性丰富、成本低、可生物降解和无毒等优点而受到越来越多的关注。然而，天然聚合物有一些限制，如储存时粘度下降，水化不受控制，溶解度，不能在高温高压下发挥作用(热稳定性)等。在许多情况下，上述天然聚合物的缺点限制了它们在药物输送系统中的应用。天然聚合物的接枝可以改善大分子骨架的性能和特征，如凝胶强度、膨胀指数、黏附、药物靶向性和药物释放谱等。因此，近几十年来，天然聚合物的接枝对于药物输送系统的发展具有巨大的重要性。除制药应用外，接枝共聚物还广泛应用于各种领域。本文综述了聚合物接枝的定义、各种接枝方法及其在给药中的应用。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.