The role of secreted osteoclastogenic factor of activated T cells in bone remodeling

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2022-11-01 DOI:10.1016/j.jdsr.2022.07.001

Ruonan Zhang, Shuang Peng, Guangxun Zhu

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引用次数: 3

Abstract

The process of bone remodeling is connected with the regulated balance between bone cell populations (including bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte). And the mechanism of bone remodeling activity is related to the major pathway, receptor activator of nuclear factor kappaB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) signaling axis. Recently, researchers have found a novel cytokine secreted by activated T cells, which is related to osteoclastogenesis in the absence of osteoblasts or RANKL, leading to bone destruction. They name it the secreted osteoclastogenic factor of activated T cells (SOFAT). SOFAT has been proven to play an essential role in bone remodeling, like mediating the bone resorption in rheumatoid arthritis (RA) and periodontitis. In this review, we outline the latest research concerning SOFAT and discuss the characteristics, location, and regulation of SOFAT. We also summarize the clinical progress of SOFAT and assume the future therapeutic target in some diseases related to bone remodeling.

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活化T细胞分泌破骨因子在骨重塑中的作用

骨重塑过程与骨细胞群(包括成骨细胞、骨吸收破骨细胞和骨细胞)之间的调节平衡有关。而骨重塑活性的机制与核因子κ b受体激活因子(RANK)/RANK配体(RANKL)/骨保护素(OPG)信号轴这一主要通路有关。最近，研究人员发现了活化T细胞分泌的一种新的细胞因子，这种细胞因子在缺乏成骨细胞或RANKL的情况下与破骨细胞的发生有关，导致骨破坏。他们将其命名为活化T细胞的分泌性破骨因子(SOFAT)。SOFAT已被证明在骨重塑中发挥重要作用，如类风湿关节炎(RA)和牙周炎的骨吸收。本文综述了SOFAT的最新研究进展，并对SOFAT的特点、定位和调控进行了探讨。总结了SOFAT的临床进展，并展望了未来在骨重塑相关疾病中的治疗靶点。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.