Determinants of Clinical Behavior and Prognosis in Cushing's Disease: A Quest for Useful Biomarkers.

IF 1.4 4区医学 Q2 Medicine Revista De Investigacion Clinica-Clinical and Translational Investigation Pub Date : 2022-01-01 DOI:10.24875/RIC.22000184

Laura C Hernández-Ramírez

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引用次数: 1

Abstract

Abstract: Cushing's disease (CD) is the most common cause of endogenous hypercortisolemia. The clinical management of this condition is complex and entails multiple therapeutic strategies, treatment of chronic comorbidities, and lifelong surveillance for recurrences and complications. The identification of robust, practical, and reliable markers of disease behavior and prognosis could potentially allow for a tailored and cost-efficient management of each patient, as well as for a reduction of the medical procedure-associated stress. For this purpose, multiple clinical, biochemical, imaging, histopathological, molecular, and genetic features have been evaluated over the years. Only a handful of them, however, have been sufficiently validated for their application in the routine care of patients with CD. This review summarizes the current status of the established and potential biomarkers of CD, bases for their use, proposed and/or established utility, as well as advantages and barriers for their implementation in the clinic. (Rev Invest Clin. 2022;74(5):244-57).

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库欣病临床行为和预后的决定因素:寻找有用的生物标志物。

摘要:库欣病(Cushing’s disease, CD)是内源性高皮质醇血症最常见的病因。这种疾病的临床管理是复杂的，需要多种治疗策略，慢性合并症的治疗，以及对复发和并发症的终身监测。识别疾病行为和预后的强大、实用和可靠的标记可能允许对每个患者进行量身定制和具有成本效益的管理，并减少医疗程序相关的压力。为此，多年来对多种临床、生化、影像学、组织病理学、分子和遗传特征进行了评估。然而，其中只有少数已被充分验证用于乳糜泻患者的常规护理。本文总结了现有的和潜在的乳糜泻生物标志物的现状，它们的使用基础，建议和/或已建立的效用，以及它们在临床应用的优势和障碍。[j] .中国科技大学学报，2014;33(5):557 - 557。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista De Investigacion Clinica-Clinical and Translational Investigation 医学-医学：内科

CiteScore

3.00

自引率

0.00%

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审稿时长

>12 weeks

期刊介绍： The Revista de Investigación Clínica – Clinical and Translational Investigation (RIC-C&TI), publishes original clinical and biomedical research of interest to physicians in internal medicine, surgery, and any of their specialties. The Revista de Investigación Clínica – Clinical and Translational Investigation is the official journal of the National Institutes of Health of Mexico, which comprises a group of Institutes and High Specialty Hospitals belonging to the Ministery of Health. The journal is published both on-line and in printed version, appears bimonthly and publishes peer-reviewed original research articles as well as brief and in-depth reviews. All articles published are open access and can be immediately and permanently free for everyone to read and download. The journal accepts clinical and molecular research articles, short reports and reviews. Types of manuscripts: – Brief Communications – Research Letters – Original Articles – Brief Reviews – In-depth Reviews – Perspectives – Letters to the Editor