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Evaluation of anti-citrullinated and anti-carbamylated antibodies in mexicans with rheumatoid arthritis and at-risk individuals.
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2025-01-20 DOI: 10.24875/RIC.24000181
Edgar E Lara-Ramírez, Betzaida Cuevas-Córdoba, Diana Olguín-Calderon, Yadira Bastian, César Ramos-Remus, José D Castillo-Ortiz, Martín Zapata-Zúñiga, Jesús Núñez-Contreras, Leendert A Trouw, José A Enciso-Moreno, Julio E Castañeda-Delgado

Background: Rheumatoid arthritis (RA) diagnosis is a challenge in the initial phases of the disease when clinical symptoms are only starting to develop. Early diagnosis and treatment can promote long-term remission, reduce disability, and improve cardiovascular outcomes. Autoantibodies can help in the diagnosis and identification of RA patients in the early phases of the disease, but scarce information has been reported for the Mexican population.

Objective: To study anti-citrullinated peptide antibodies (anti-CCP) and anti-carbamylated protein antibodies (anti-CarP) in Mexican patients with RA and individuals at high risk of developing the disease.

Methods: Serum samples from long-standing and early RA patients, first-degree relatives (FstD) of RA patients, and healthy individuals were analyzed for anti-CCP and anti-CarP using enzyme-linked immunosorbent assay.

Results: Anti-CCP and anti-CarP levels were higher in the RA groups than in the FstD and healthy groups. The odds ratio (OR) for antiCCP for RA groups was 29.7 (95% confidence interval [CI] 14.2-61.9), significantly higher than the OR for anti-CarP 11.07 (95% CI 5.4-22.8). The sensitivity of anti-CCP was 85% (95% CI 76-93) higher than for anti-CarP (42.1%, 95% CI 31-54). The specificity of anti-CarP was 93.8% (95% CI 90-97) and the specificity of anti-CCP was 83.4% (95% CI 78-88). Using both tests in parallel increased sensitivity to 91%, while a sequential approach increased sensitivity to 98%.

Conclusion: Anti-CCP outperformed anti-CarP in Mexican RA patients, demonstrating greater sensitivity, while anti-CarP showed higher specificity. Combining these tests, either simultaneously or sequentially, could enhance diagnostic accuracy. (.

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引用次数: 0
MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center. MIR-155作为st段抬高型心肌梗死疾病严重程度的潜在生物标志物:来自大学附属心血管中心的见解
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2025-01-14 DOI: 10.24875/RIC.24000189
Ailyn Morales-Rentería, Amina Ruiz-Santos, Luis M Amezcua-Castillo, Jazmín A Guerra-López, Kietseé A Díaz-Domínguez, José L Sánchez-Gloria, Héctor González-Pacheco, Luis M Amezcua-Guerra

Background: MiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established.

Objective: To investigate associations between miR-155 levels, inflammation, atherosclerotic burden, and major adverse cardiovascular events (MACE) in STEMI patients.

Methods: Sixty-nine STEMI patients and 16 healthy controls were recruited from a specialized university-affiliated cardiovascular center. MiR-155 expression and serum interleukin (IL)-1β, IL-6, and tumor necrosis factor levels were measured. Patients were grouped into tertiles based on miR-155 expression. Clinical data, atherosclerotic burden (through cardiac catheterization), and in-hospital MACE were recorded.

Results: MiR-155 levels were significantly lower in STEMI patients compared to controls (median 54.2, vs. 152.8 arbitrary units; p = 0.003). Higher miR-155 tertiles were associated with a greater prevalence of three-vessel occlusion (34% vs. 13% vs. 4%; p = 0.007) and increased incidence of pulmonary edema (13% vs. 0% vs. 0%; p = 0.030). No significant correlation was found between miR-155 and inflammatory or myocardial markers.

Conclusion: Dysregulated miR-155 expression in STEMI patients may influence disease severity and MACE risk, independent of inflammation or myocardial damage markers.

背景:MiR-155在炎症途径和心血管疾病中发挥作用,尽管其与炎症、动脉粥样硬化和st段抬高型心肌梗死(STEMI)结局的关系尚不清楚。目的:探讨STEMI患者miR-155水平、炎症、动脉粥样硬化负担和主要不良心血管事件(MACE)之间的关系。方法:从某大学附属心血管专科中心招募69例STEMI患者和16例健康对照。检测MiR-155表达、血清白细胞介素(IL)-1β、IL-6和肿瘤坏死因子水平。根据miR-155的表达将患者分组。记录临床资料、动脉粥样硬化负担(通过心导管)和住院MACE。结果:与对照组相比,STEMI患者的MiR-155水平显著降低(中位数为54.2,对152.8任意单位;P = 0.003)。较高的miR-155位数与较高的三支血管闭塞患病率相关(34% vs. 13% vs. 4%;P = 0.007)和肺水肿发生率增加(13% vs. 0% vs. 0%;P = 0.030)。miR-155与炎症或心肌标志物之间无显著相关性。结论:STEMI患者miR-155表达异常可能影响疾病严重程度和MACE风险,与炎症或心肌损伤标志物无关。
{"title":"MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center.","authors":"Ailyn Morales-Rentería, Amina Ruiz-Santos, Luis M Amezcua-Castillo, Jazmín A Guerra-López, Kietseé A Díaz-Domínguez, José L Sánchez-Gloria, Héctor González-Pacheco, Luis M Amezcua-Guerra","doi":"10.24875/RIC.24000189","DOIUrl":"10.24875/RIC.24000189","url":null,"abstract":"<p><strong>Background: </strong>MiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established.</p><p><strong>Objective: </strong>To investigate associations between miR-155 levels, inflammation, atherosclerotic burden, and major adverse cardiovascular events (MACE) in STEMI patients.</p><p><strong>Methods: </strong>Sixty-nine STEMI patients and 16 healthy controls were recruited from a specialized university-affiliated cardiovascular center. MiR-155 expression and serum interleukin (IL)-1β, IL-6, and tumor necrosis factor levels were measured. Patients were grouped into tertiles based on miR-155 expression. Clinical data, atherosclerotic burden (through cardiac catheterization), and in-hospital MACE were recorded.</p><p><strong>Results: </strong>MiR-155 levels were significantly lower in STEMI patients compared to controls (median 54.2, vs. 152.8 arbitrary units; p = 0.003). Higher miR-155 tertiles were associated with a greater prevalence of three-vessel occlusion (34% vs. 13% vs. 4%; p = 0.007) and increased incidence of pulmonary edema (13% vs. 0% vs. 0%; p = 0.030). No significant correlation was found between miR-155 and inflammatory or myocardial markers.</p><p><strong>Conclusion: </strong>Dysregulated miR-155 expression in STEMI patients may influence disease severity and MACE risk, independent of inflammation or myocardial damage markers.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"013-025"},"PeriodicalIF":1.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers of Oxidative Stress, Inflammation, and Brain Damage in Mexican Women over 60 Years of Age with Obesity.
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2025-01-01 DOI: 10.24875/RIC.24000207
Luna-López Armando, Lira-Rotstein Julián de Jesús, Librado-Osorio Raúl, Santín-Márquez Roberto, Rosas-Carrasco Óscar, Königsberg Mina

Unassigned: Background: Obesity and aging are risk factors for chronic degenerative diseases that favor neuroinflammation leading to cognitive and motor impairment. Mexico ranks second in obesity worldwide, being more prevalent in the female population. Objectives: To determine whether serum biomarkers of obesity, inflammation, oxidative stress, and brain damage vary according to age, sex, and ethnicity, we studied Mexican elderly women with obesity since this population has been historically neglected. Methods: A total of 156 women over 60 years of age (89 obese and 67 non-obese) were selected from the FraDySMex-2019 Cohort study samples. Serum markers of inflammation (Interleukin [IL]-6, tumor necrosis factor-α, IL-10, adiponectin, and peroxisome proliferator-activated receptor gamma [PPAR-γ]), and neurodegeneration (glial fibrillary acidic protein, brain-derived neurotrophic factor, and S100B), redox status (GSH/GSSG ratio), and protein oxidative damage were assessed. A biochemical profile was obtained and used for a factor analysis including their morphometric data. Results: The data from the participating elderly women clustered in relation to their obesity characteristics. The markers that were higher in obese women were GSSG, protein carbonylation, IL-6, and S100B, along with lower levels of adiponectin and PPAR-γ, suggesting they could be interesting biomarkers of neuroinflammation in obese Mexican women. Conclusion: Further case-control studies must be implemented to validate their prognosis value in elderly obese Mexican women with cognitive impairment. (Rev Invest Clin. 2025;77(1):13-25).

{"title":"Biomarkers of Oxidative Stress, Inflammation, and Brain Damage in Mexican Women over 60 Years of Age with Obesity.","authors":"Luna-López Armando, Lira-Rotstein Julián de Jesús, Librado-Osorio Raúl, Santín-Márquez Roberto, Rosas-Carrasco Óscar, Königsberg Mina","doi":"10.24875/RIC.24000207","DOIUrl":"https://doi.org/10.24875/RIC.24000207","url":null,"abstract":"<p><strong>Unassigned: </strong>Background: Obesity and aging are risk factors for chronic degenerative diseases that favor neuroinflammation leading to cognitive and motor impairment. Mexico ranks second in obesity worldwide, being more prevalent in the female population. Objectives: To determine whether serum biomarkers of obesity, inflammation, oxidative stress, and brain damage vary according to age, sex, and ethnicity, we studied Mexican elderly women with obesity since this population has been historically neglected. Methods: A total of 156 women over 60 years of age (89 obese and 67 non-obese) were selected from the FraDySMex-2019 Cohort study samples. Serum markers of inflammation (Interleukin [IL]-6, tumor necrosis factor-α, IL-10, adiponectin, and peroxisome proliferator-activated receptor gamma [PPAR-γ]), and neurodegeneration (glial fibrillary acidic protein, brain-derived neurotrophic factor, and S100B), redox status (GSH/GSSG ratio), and protein oxidative damage were assessed. A biochemical profile was obtained and used for a factor analysis including their morphometric data. Results: The data from the participating elderly women clustered in relation to their obesity characteristics. The markers that were higher in obese women were GSSG, protein carbonylation, IL-6, and S100B, along with lower levels of adiponectin and PPAR-γ, suggesting they could be interesting biomarkers of neuroinflammation in obese Mexican women. Conclusion: Further case-control studies must be implemented to validate their prognosis value in elderly obese Mexican women with cognitive impairment. (Rev Invest Clin. 2025;77(1):13-25).</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 1","pages":"13-25"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Delayed HLA Haploidentical Transplantation with Peripheral Blood Allografts for High-Risk Patients with Severe Aplastic Anemia.
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2025-01-01 DOI: 10.24875/RIC.25000012
Jaime-Pérez José C, González-Treviño Mariana, Barragán-Longoria Renata V, Cantú-Rodríguez Olga G, Gutiérrez-Aguirre César H, Gómez-Almaguer David

Unassigned: Background: In severe aplastic anemia (AA) sibling haploidentical hematopoietic stem cell transplantation (haplo-HSCT) from the peripheral blood (PB) is an alternative when an HLA-identical donor is unavailable. Objective: To document the results of haplo-HSCT in high-risk severe AA. Methods: Twelve patients with severe AA who failed medical therapy and received a haploidentical PB unmanipulated HSCT from a sibling at an academic medical center were analyzed. Overall (OS) and event-free survival (EFS) were determined by Kaplan-Meier analyses. Results: The median between AA diagnosis and haplo-HSCT was 6.5 months (2-19). Median of age was 25.5 (range, 4-54) years; 9 (75%) recipients were males, and all suffered multiple treatment failures. Anti-thymocyte globulin-based conditioning regimens were given to 6 (50%) patients. Five (41.7%) HSCT were ambulatory. Infections developed in all patients and graft failure in 9 (75%). 2-year OS was 52% and EFS 25%. High transfusion burden, treatment failure, and donors > 30 years had no effect on OS (p = 0.518, p = 0.984, p = 0.321) or EFS (p = 0.113, p = 0.692, p = 0.199). Patient's age > 40 was not significant for survival (p = 0.395). Three of five evaluable patients developed acute graft-versus-host disease that progressed to chronic disease. Conclusions: Delayed PB haplo-HSCT for severe AA offered poor outcomes. Rapid referral for HSCT is critically required. (Rev Invest Clin. 2025;77(1):26-33).

{"title":"Outcomes of Delayed HLA Haploidentical Transplantation with Peripheral Blood Allografts for High-Risk Patients with Severe Aplastic Anemia.","authors":"Jaime-Pérez José C, González-Treviño Mariana, Barragán-Longoria Renata V, Cantú-Rodríguez Olga G, Gutiérrez-Aguirre César H, Gómez-Almaguer David","doi":"10.24875/RIC.25000012","DOIUrl":"https://doi.org/10.24875/RIC.25000012","url":null,"abstract":"<p><strong>Unassigned: </strong>Background: In severe aplastic anemia (AA) sibling haploidentical hematopoietic stem cell transplantation (haplo-HSCT) from the peripheral blood (PB) is an alternative when an HLA-identical donor is unavailable. Objective: To document the results of haplo-HSCT in high-risk severe AA. Methods: Twelve patients with severe AA who failed medical therapy and received a haploidentical PB unmanipulated HSCT from a sibling at an academic medical center were analyzed. Overall (OS) and event-free survival (EFS) were determined by Kaplan-Meier analyses. Results: The median between AA diagnosis and haplo-HSCT was 6.5 months (2-19). Median of age was 25.5 (range, 4-54) years; 9 (75%) recipients were males, and all suffered multiple treatment failures. Anti-thymocyte globulin-based conditioning regimens were given to 6 (50%) patients. Five (41.7%) HSCT were ambulatory. Infections developed in all patients and graft failure in 9 (75%). 2-year OS was 52% and EFS 25%. High transfusion burden, treatment failure, and donors > 30 years had no effect on OS (p = 0.518, p = 0.984, p = 0.321) or EFS (p = 0.113, p = 0.692, p = 0.199). Patient's age > 40 was not significant for survival (p = 0.395). Three of five evaluable patients developed acute graft-versus-host disease that progressed to chronic disease. Conclusions: Delayed PB haplo-HSCT for severe AA offered poor outcomes. Rapid referral for HSCT is critically required. (Rev Invest Clin. 2025;77(1):26-33).</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"77 1","pages":"26-33"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pontine and Extrapontine Myelinolysis: Risk Factors and Characterization of Patients Diagnosed in Three Decades in a Tertiary Center.
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2025-01-01 DOI: 10.24875/RIC.24000213
Almeida-Arvizu Anahi, Vega-Vega Olynka, Rincón-Pedrero Rodolfo, Noemí del Toro-Cisneros

Unassigned: Background: Osmotic demyelination syndrome is a rare neurological disorder caused by damage to the myelin sheath of oligodendrocytes, typically due to a rapid increase in serum osmolarity. Objective: The objective of the study was to investigate the factors associated with the development of pontine or extrapontine myelinolysis. Methods: A retrospective, observational study which included patients with magnetic resonance imaging-confirmed diagnosis of pontine and extrapontine myelinolysis from 1990 to 2024 at a referral hospital in Mexico City. Results: Fourteen patients were included; the median age was 49 years, and 35.7% were men. Regarding comorbidities, diabetes was the most frequent (35.7%), followed by liver cirrhosis, malnutrition, and chronic alcoholism. Significantly, hyponatremia was found in 11 patients (78.5%), being severe in 42.8% of the patients. Other frequent biochemical abnormalities were hypokalemia (42.8%) and hypomagnesemia in 5 (35.7%). Sodium overcorrection occurred in 50% of patients, and the 90-day mortality rate was 28.5%. Conclusions: Electrolyte disturbances, particularly hyponatremia, were common in this population, along with the comorbidities traditionally associated with this condition. Although neurological sequelae and mortality have decreased over time, they remain present in 64% and 28.5% of patients, respectively. (Rev Invest Clin. 2025;77(1):1-5).

未分配:背景:渗透性脱髓鞘综合征是一种罕见的神经系统疾病,由少突胶质细胞髓鞘受损引起,通常是由于血清渗透压快速升高所致。研究目的本研究旨在探讨与发生桥脑或桥脑外髓鞘溶解相关的因素。研究方法回顾性观察研究,包括墨西哥城一家转诊医院 1990 年至 2024 年期间磁共振成像确诊为桥脑和桥外髓鞘溶解症的患者。研究结果共纳入 14 名患者,中位年龄为 49 岁,35.7% 为男性。在合并症方面,糖尿病最常见(35.7%),其次是肝硬化、营养不良和慢性酒精中毒。值得注意的是,11 名患者(78.5%)出现了低钠血症,其中 42.8% 的患者病情严重。其他常见的生化异常还有低钾血症(42.8%)和低镁血症(5 人,35.7%)。50%的患者出现钠过量,90天死亡率为28.5%。结论电解质紊乱,尤其是低钠血症,以及传统上与这种疾病相关的合并症,在这一人群中很常见。尽管随着时间的推移,神经系统后遗症和死亡率有所下降,但仍分别有64%和28.5%的患者出现这种情况。(Rev Invest Clin.2025;77(1):1-5).
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引用次数: 0
Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome. 针对墨西哥吉兰-巴雷综合征患者的功能预后量表提案。
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2024-11-21 DOI: 10.24875/RIC.24000149
Edwin S Vargas-Cañas, Juan C López-Hernández, Sandra Badial-Ochoa, Javier Galnares-Olalde, Victoria Martínez-Angeles, Elliot Hernández-Angelino, David Domínguez-Romero, Raúl Medina-Rioja

Background: There is currently no prognostic scale for patients with Guillain-Barré syndrome (GBS) in the Mexican population.

Objective: The objective of the study was to examine the factors associated with functional prognosis by proposing short-term and long-term prognostic scales.

Methods: Prospective cohort of patients with GBS at an academic medical center, with neuroconduction study and 6-month follow-up. Through logistic regression, we evaluated clinical and paraclinical variables, and the results are expressed as odds ratios 95% confidence intervals [CIs]). We used a scale to predict poor functional prognosis. The performance of the scale was assessed using the area under the curve (AUC).

Results: A total of 259 patients (age 46.1 +- 16.1 years) were included in the study; 38.6% had a history of diarrhea, and 42.8% had an axonal variant. The rates of poor functional prognosis were 36.6% and 22.7% at 3 and 6 months of follow-up, respectively. The following variables were included in the univariate logistic regression: age >- 70 years, history of diarrhea, axonal variant, and Medical Research Council score. We performed a prognostic scale (0-9 points), with AUC of 0.81 (95% CI: 0.75-0.86) at 3 months, and 0.82 (95% CI: 0.76-0.87) at 6 months, which was higher than the modified Erasmus Guillain-Barré Outcome Score scale at admission (AUC: 0.75. 95% CI: 0.69-0.81 and AUC: 0.78. 95% CI: 0.72-0.83).

Conclusion: The proposed prognostic scale performs well in discerning poor functional prognosis in short- and long-term frames among Mexican patients.

背景:目前还没有针对墨西哥吉兰-巴雷综合征患者的预后量表:目前还没有针对墨西哥吉兰-巴雷综合征(GBS)患者的预后量表:本研究旨在通过提出短期和长期预后量表,研究与功能性预后相关的因素:方法:对一家学术医疗中心的 GBS 患者进行前瞻性队列研究,并进行神经传导研究和 6 个月的随访。通过逻辑回归,我们对临床和辅助临床变量进行了评估,结果以几率(95% 置信区间 [CIs])表示。我们使用一个量表来预测不良功能预后。结果:研究共纳入 259 名患者(年龄 46.1 +- 16.1 岁),其中 38.6% 有腹泻病史,42.8% 有轴索变异。随访3个月和6个月时,功能预后不良的比例分别为36.6%和22.7%。单变量逻辑回归包括以下变量:年龄大于 70 岁、腹泻史、轴突变异和医学研究委员会评分。我们采用了预后量表(0-9分),3个月时的AUC为0.81(95% CI:0.75-0.86),6个月时的AUC为0.82(95% CI:0.76-0.87),高于入院时的改良伊拉斯谟吉兰-巴雷预后量表(AUC:0.75,95% CI:0.69-0.81,AUC:0.78,95% CI:0.72-0.83):结论:拟议的预后量表在判别墨西哥患者短期和长期功能预后不良方面表现良好。
{"title":"Proposal of a functional prognostic scale in mexican patients with Guillain-Barré syndrome.","authors":"Edwin S Vargas-Cañas, Juan C López-Hernández, Sandra Badial-Ochoa, Javier Galnares-Olalde, Victoria Martínez-Angeles, Elliot Hernández-Angelino, David Domínguez-Romero, Raúl Medina-Rioja","doi":"10.24875/RIC.24000149","DOIUrl":"10.24875/RIC.24000149","url":null,"abstract":"<p><strong>Background: </strong>There is currently no prognostic scale for patients with Guillain-Barré syndrome (GBS) in the Mexican population.</p><p><strong>Objective: </strong>The objective of the study was to examine the factors associated with functional prognosis by proposing short-term and long-term prognostic scales.</p><p><strong>Methods: </strong>Prospective cohort of patients with GBS at an academic medical center, with neuroconduction study and 6-month follow-up. Through logistic regression, we evaluated clinical and paraclinical variables, and the results are expressed as odds ratios 95% confidence intervals [CIs]). We used a scale to predict poor functional prognosis. The performance of the scale was assessed using the area under the curve (AUC).</p><p><strong>Results: </strong>A total of 259 patients (age 46.1 +- 16.1 years) were included in the study; 38.6% had a history of diarrhea, and 42.8% had an axonal variant. The rates of poor functional prognosis were 36.6% and 22.7% at 3 and 6 months of follow-up, respectively. The following variables were included in the univariate logistic regression: age >- 70 years, history of diarrhea, axonal variant, and Medical Research Council score. We performed a prognostic scale (0-9 points), with AUC of 0.81 (95% CI: 0.75-0.86) at 3 months, and 0.82 (95% CI: 0.76-0.87) at 6 months, which was higher than the modified Erasmus Guillain-Barré Outcome Score scale at admission (AUC: 0.75. 95% CI: 0.69-0.81 and AUC: 0.78. 95% CI: 0.72-0.83).</p><p><strong>Conclusion: </strong>The proposed prognostic scale performs well in discerning poor functional prognosis in short- and long-term frames among Mexican patients.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":" ","pages":"253-261"},"PeriodicalIF":1.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LINC01614 activated by SP1 promoted malignant behavior of triple-negative breast cancer cells via the WNT/b-Catenin signaling pathway. SP1激活的LINC01614通过WNT/b-Catenin信号通路促进了三阴性乳腺癌细胞的恶性行为。
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2024-10-17 DOI: 10.24875/RIC.24000093
Tao Chen, Kenzi Shi, Shengrong Sun

Background: Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer (BC), characterized by a dismal prognosis. Dysregulated long non-coding RNA LINC01614 might be a potential biomarker for BC as previously reported. Nevertheless, its functions and mechanism in TNBC cells are unclear.

Objectives: The study aimed to study the effects of LINC01614 on TNBC cell migration, invasion, and epithelial-mesenchymal transition (EMT) process as well as the related mechanism.

Methods: Reverse transcription quantitative polymerase chain reaction was performed to detect the expression of LINC01614 and SP1 in TNBC cells and tissues. The cellular localization of LINC01614 was determined by subcellular fraction assays. Cell counting kit-8 and Transwell invasion assays were conducted for measurement of TNBC cell viability and invasive ability. Cell migration was performed using wound healing assays and Transwell migration assays. Chromatin immunoprecipitation assays and luciferase reporter assays were used to explore the interaction between SP1 and LINC01614. Western blotting was used to assess protein levels of factors involved in EMT process and Wnt/ß-catenin signaling in TNBC cells.

Results: LINC01614 expression was elevated in TNBC tissues and cells. LINC01614 knockdown inhibited cell viability as well as migratory and invasive abilities of TNBC cells. LINC01614 knockdown also obstructed EMT process, as shown by E-cadherin upregulation and vimentin downregulation in TNBC cells. SP1 directly bound to the promoter of LINC01614 and activated LINC01614 expression. SP1 overexpression reversed the suppressive effect of LINC01614 knockdown on TNBC cell migration, invasion, and EMT process. Protein levels of Wnt and ß-catenin were diminished by LINC01614 knockdown, and the trend was partially rescued by SP1 overexpression.

Conclusion: SP1-induced LINC01614 promoted malignant behavior of TNBC cells by activating the Wnt/ß-catenin signaling pathway.

背景:三阴性乳腺癌(TNBC三阴性乳腺癌(TNBC)是乳腺癌(BC)中侵袭性最强的亚型,预后极差。正如之前所报道的,失调的长非编码 RNA LINC01614 可能是乳腺癌的潜在生物标志物。然而,它在 TNBC 细胞中的功能和机制尚不清楚:本研究旨在研究LINC01614对TNBC细胞迁移、侵袭和上皮-间质转化(EMT)过程的影响及其相关机制:方法:采用逆转录定量聚合酶链反应检测LINC01614和SP1在TNBC细胞和组织中的表达。LINC01614的细胞定位是通过亚细胞分馏检测确定的。细胞计数试剂盒-8和Transwell侵袭试验用于测量TNBC细胞的活力和侵袭能力。使用伤口愈合试验和 Transwell 迁移试验进行细胞迁移。染色质免疫沉淀实验和荧光素酶报告实验用于探索 SP1 和 LINC01614 之间的相互作用。用 Western 印迹法评估 TNBC 细胞中参与 EMT 过程和 Wnt/ß-catenin 信号转导的因子的蛋白水平:结果:LINC01614在TNBC组织和细胞中表达升高。LINC01614敲除抑制了TNBC细胞的活力、迁移和侵袭能力。LINC01614 基因敲除还阻碍了 TNBC 细胞的 EMT 过程,表现为 E-cadherin 上调和波形蛋白下调。SP1直接与LINC01614的启动子结合并激活LINC01614的表达。SP1的过表达逆转了LINC01614敲除对TNBC细胞迁移、侵袭和EMT过程的抑制作用。LINC01614敲除会降低Wnt和ß-catenin的蛋白水平,SP1过表达可部分缓解这一趋势:结论:SP1诱导的LINC01614通过激活Wnt/ß-catenin信号通路促进了TNBC细胞的恶性行为。
{"title":"LINC01614 activated by SP1 promoted malignant behavior of triple-negative breast cancer cells via the WNT/b-Catenin signaling pathway.","authors":"Tao Chen, Kenzi Shi, Shengrong Sun","doi":"10.24875/RIC.24000093","DOIUrl":"10.24875/RIC.24000093","url":null,"abstract":"<p><strong>Background: </strong>Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer (BC), characterized by a dismal prognosis. Dysregulated long non-coding RNA LINC01614 might be a potential biomarker for BC as previously reported. Nevertheless, its functions and mechanism in TNBC cells are unclear.</p><p><strong>Objectives: </strong>The study aimed to study the effects of LINC01614 on TNBC cell migration, invasion, and epithelial-mesenchymal transition (EMT) process as well as the related mechanism.</p><p><strong>Methods: </strong>Reverse transcription quantitative polymerase chain reaction was performed to detect the expression of LINC01614 and SP1 in TNBC cells and tissues. The cellular localization of LINC01614 was determined by subcellular fraction assays. Cell counting kit-8 and Transwell invasion assays were conducted for measurement of TNBC cell viability and invasive ability. Cell migration was performed using wound healing assays and Transwell migration assays. Chromatin immunoprecipitation assays and luciferase reporter assays were used to explore the interaction between SP1 and LINC01614. Western blotting was used to assess protein levels of factors involved in EMT process and Wnt/ß-catenin signaling in TNBC cells.</p><p><strong>Results: </strong>LINC01614 expression was elevated in TNBC tissues and cells. LINC01614 knockdown inhibited cell viability as well as migratory and invasive abilities of TNBC cells. LINC01614 knockdown also obstructed EMT process, as shown by E-cadherin upregulation and vimentin downregulation in TNBC cells. SP1 directly bound to the promoter of LINC01614 and activated LINC01614 expression. SP1 overexpression reversed the suppressive effect of LINC01614 knockdown on TNBC cell migration, invasion, and EMT process. Protein levels of Wnt and ß-catenin were diminished by LINC01614 knockdown, and the trend was partially rescued by SP1 overexpression.</p><p><strong>Conclusion: </strong>SP1-induced LINC01614 promoted malignant behavior of TNBC cells by activating the Wnt/ß-catenin signaling pathway.</p>","PeriodicalId":49612,"journal":{"name":"Revista De Investigacion Clinica-Clinical and Translational Investigation","volume":"76 4","pages":"185-194"},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Diagnostic Workup for hypertensive Intracerebral hemorrhage: a retrospective LATAM cerebrovascular registry comparison. 扩大高血压性脑出血的诊断范围:拉丁美洲和加勒比海地区脑血管登记处的回顾性比较。
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2024-09-23 DOI: 10.24875/RIC.24000142
Amado Jiménez-Ruiz, Naomi N Becerra-Aguiar, Victor Aguilar-Fuentes, Juan C Ayala-Alvarez, Enrique Gómez-Figueroa, Carlos Cantú, Antonio Arauz, Fabiola Serrano-Arias, José L Ruiz-Sandoval

Background: The leading cause of spontaneous intracerebral hemorrhage (ICH) is hypertensive arteriolopathy. In addition to age and hypertension history, patients usually present other comorbidities that potentially increase morbimortality. Ancillary studies other than non-contrast computerized tomography (NCCT) may help clarify the diagnosis and increase the detection of potentially modifiable vascular risk factors. Unfortunately, their use is not routinely performed.

Objective: The study aimed to determine the frequency of ancillary studies performed in patients with hypertensive ICH.

Methods: We performed a retrospective analysis of three Latin American cerebrovascular registries from academic medical centers, analyzing the results with descriptive statistics focusing on diagnosis and short-term outcomes.

Results: We analyzed a total of 1,324 patients (mean age 64 years). Hypertension and obesity were the most prevalent risk factors. Only 14% underwent MRI, 10.3% extracranial ultrasonography, and 6.7% echocardiography. Among the three registries, the Latin America Stroke Registry performed more ancillary studies. Most of the patients presented a poor clinical outcome and in-hospital death.

Conclusions: The use of ancillary studies in the diagnostic workup of ICH was poor in the three registries, and mortality was high. The lack of ancillary studies performed may negatively impact outcomes.

背景:自发性脑内出血(ICH)的主要病因是高血压动脉病变。除年龄和高血压病史外,患者通常还伴有其他可能增加死亡率的并发症。非对比计算机断层扫描(NCCT)以外的辅助检查有助于明确诊断,并能发现更多潜在的可改变的血管风险因素。遗憾的是,这些辅助检查并未被常规使用:本研究旨在确定高血压 ICH 患者进行辅助检查的频率:我们对拉丁美洲三家学术医疗中心的脑血管登记资料进行了回顾性分析,并对结果进行了描述性统计分析,重点关注诊断和短期疗效:我们共分析了 1,324 名患者(平均年龄 64 岁)。高血压和肥胖是最常见的风险因素。只有14%的患者接受了核磁共振成像检查,10.3%的患者接受了颅外超声波检查,6.7%的患者接受了超声心动图检查。在这三个登记处中,拉丁美洲卒中登记处进行了更多的辅助检查。大多数患者的临床预后不佳,并出现院内死亡:结论:三个登记处在诊断 ICH 时辅助检查的使用率较低,死亡率较高。缺乏辅助检查可能会对预后产生负面影响。
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引用次数: 0
Validation of the HAS-BLED scale for the assessment of bleeding risk in patients on anticoagulation therapy with a diagnosis of venous thromboembolic disease. 对 HAS-BLED 量表进行验证,以评估确诊为静脉血栓栓塞性疾病的抗凝治疗患者的出血风险。
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2024-09-05 DOI: 10.24875/RIC.24000147
Stephanie Ortiz-Gómez, Paula Ruiz-Talero, Oscar Muñoz

Background: Several models have been developed to assess bleeding risk in patients with venous thromboembolism, such as HAS-BLED, but their external validity has not been adequately assessed.

Objective: The objective of the study was to evaluate the discriminative ability and calibration of the HAS-BLED scale for predicting 1-month bleeding risk in patient's anticoagulated for venous thromboembolism.

Materials and methods: External validation study of a prediction model based on a retrospective cohort of patients with venous thromboembolism treated between November 2019 and January 2022. Calibration of the HAS-BLED scale was evaluated using the Hosmer-Lemeshow test and the ratio of observed to expect events within each risk category. Discriminatory ability was assessed using the area under the curve (AUC) of a receiver operating characteristic curve.

Results: We included 735 patients (median age 64 years, female sex 55.2%), pulmonary embolism was diagnosed in most patients (60.7%), and 4.9% presented bleeding events. Regarding calibration, the HAS-BLED scale systematically underestimates the risk both in the general population (ROE 3.76, p < 0.001) and in cancer patients (ROE 4.16). The Hosmer-Lemeshow test rejected the hypothesis of adequate calibration (p < 0.001). Discriminatory ability was limited both in the general population (AUC = 0.57, 95% confidence interval [CI]: 0.48-0.66) and in the subgroup with active cancer (AUC = 0.53, 95% CI: 0.36-0.69).

Conclusion: The HAS-BLED scale in patients with venous thromboembolism underestimates the risk of bleeding at 1 month and has a low ability to discriminate high-risk patients. Cautious interpretation of the scale is recommended until additional evidence is available.

背景:目前已开发出几种用于评估静脉血栓栓塞症患者出血风险的模型,如 HAS-BLED,但其外部有效性尚未得到充分评估:目前已开发出几种评估静脉血栓栓塞症患者出血风险的模型,如HAS-BLED,但其外部有效性尚未得到充分评估:本研究旨在评估 HAS-BLED 量表预测静脉血栓栓塞抗凝患者 1 个月出血风险的鉴别能力和校准:基于2019年11月至2022年1月期间接受治疗的静脉血栓栓塞症患者回顾性队列的预测模型的外部验证研究。使用 Hosmer-Lemeshow 检验和每个风险类别中观察到的事件与预期事件的比率评估 HAS-BLED 量表的校准。使用接收者操作特征曲线的曲线下面积(AUC)评估判别能力:我们共纳入了 735 名患者(中位年龄 64 岁,女性占 55.2%),大多数患者(60.7%)确诊为肺栓塞,4.9% 的患者出现了出血事件。在校准方面,HAS-BLED 量表系统性地低估了普通人群(ROE 3.76,P < 0.001)和癌症患者(ROE 4.16)的风险。Hosmer-Lemeshow 检验拒绝了充分校准的假设(p < 0.001)。在普通人群(AUC = 0.57,95% 置信区间[CI]:0.48-0.66)和活动性癌症亚组(AUC = 0.53,95% 置信区间:0.36-0.69)中,判别能力均有限:结论:HAS-BLED量表低估了静脉血栓栓塞患者1个月后的出血风险,对高危患者的鉴别能力较低。在获得更多证据之前,建议谨慎解释该量表。
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引用次数: 0
Genotypes distribution of the SNP RS1477196 of FTO gen associated with primary knee osteoarthritis in females: an analysis using the 100Genomes database. 与女性原发性膝骨关节炎相关的 FTO 基因 SNP RS1477196 的基因型分布:利用 100Genomes 数据库进行的分析。
IF 1.4 4区 医学 Q2 Medicine Pub Date : 2024-09-05 DOI: 10.24875/RIC.24000159
Ángel Roco-Videla, Sergio V Flores, Mariela Olguin-Barraza
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引用次数: 0
期刊
Revista De Investigacion Clinica-Clinical and Translational Investigation
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