{"title":"Clinical Study of Dexmedetomidine in Combination with Butorphanol for the Treatment of Traumatic Brain Injury (TBI).","authors":"Xuejian Wang, Zhifeng Wang, Chen Sun, Zhiming Cui","doi":"10.5137/1019-5149.JTN.36585-21.2","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To explore whether the combination of dexmedetomidine (Dex) and butorphanol (But) could benefit patients with traumatic brain injury (TBI).</p><p><strong>Material and methods: </strong>A total of 208 TBI patients admitted from February 2018 to January 2020 were randomly divided into four groups as follows: control group (A), Dex group (B), But group (C), and combination of dexmedetomidine and butorphanol group (D). Four groups of patients were treated and studied clinically. Statistical analysis was performed to assess the changes in signs of life, oxygen saturation, serum neuroendocrine data, pain, and agitation scores.</p><p><strong>Results: </strong>The statistical data of signs of life and blood oxygen saturation of the four groups were compared, and the differences between group A and group D were statistically significant (p < 0.05), indicating that a combination of sedative and analgesic agents at low doses could improve the signs of life of TBI patients, and the safety was relatively good. The Glasgow Coma Scale (GCS) score of the group D on the 5th day post-surgery was improved compared with the control group (A group), suggesting that the combination of sedative and analgesic agents could improve patients' consciousness. The neuroendocrine data of the combination group showed little fluctuation, indicating that a combination of sedative and analgesic agents could significantly reduce the stress response. The scores of pain and agitation in the combination group were significantly improved on the 3rd and 5th days, suggesting that the combination group was better compared with the control group.</p><p><strong>Conclusion: </strong>The combination of Dex and But was more stable for the treatment of vital signs. Compared with the individual treatment groups, the patients in the combination group had a rapid improvement. The time from treatment to stabilization was shortened, and the prognosis was significantly better compared with the control group. A combination of Dex and But at low doses could significantly maintain neuroendocrine stability. Meanwhile, a combination of sedative and analgesic agents had obvious synergistic effects on enhancing sedation and analgesia as well as anti-muscle tension. Collectively, the combination of Dex and But could significantly benefit the prognosis of TBI.</p>","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5137/1019-5149.JTN.36585-21.2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To explore whether the combination of dexmedetomidine (Dex) and butorphanol (But) could benefit patients with traumatic brain injury (TBI).
Material and methods: A total of 208 TBI patients admitted from February 2018 to January 2020 were randomly divided into four groups as follows: control group (A), Dex group (B), But group (C), and combination of dexmedetomidine and butorphanol group (D). Four groups of patients were treated and studied clinically. Statistical analysis was performed to assess the changes in signs of life, oxygen saturation, serum neuroendocrine data, pain, and agitation scores.
Results: The statistical data of signs of life and blood oxygen saturation of the four groups were compared, and the differences between group A and group D were statistically significant (p < 0.05), indicating that a combination of sedative and analgesic agents at low doses could improve the signs of life of TBI patients, and the safety was relatively good. The Glasgow Coma Scale (GCS) score of the group D on the 5th day post-surgery was improved compared with the control group (A group), suggesting that the combination of sedative and analgesic agents could improve patients' consciousness. The neuroendocrine data of the combination group showed little fluctuation, indicating that a combination of sedative and analgesic agents could significantly reduce the stress response. The scores of pain and agitation in the combination group were significantly improved on the 3rd and 5th days, suggesting that the combination group was better compared with the control group.
Conclusion: The combination of Dex and But was more stable for the treatment of vital signs. Compared with the individual treatment groups, the patients in the combination group had a rapid improvement. The time from treatment to stabilization was shortened, and the prognosis was significantly better compared with the control group. A combination of Dex and But at low doses could significantly maintain neuroendocrine stability. Meanwhile, a combination of sedative and analgesic agents had obvious synergistic effects on enhancing sedation and analgesia as well as anti-muscle tension. Collectively, the combination of Dex and But could significantly benefit the prognosis of TBI.
期刊介绍:
Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.