Real-world health outcomes in US adult patients with mild to moderate plaque psoriasis taking topical therapy.

IF 2.9 4区 医学 Q2 DERMATOLOGY Journal of Dermatological Treatment Pub Date : 2022-09-01 Epub Date: 2022-08-03 DOI:10.1080/09546634.2022.2085862
David Kaplan, James Hetherington, James Lucas, Ibrahim Khilfeh, Tara Nazareth
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Abstract

Background: Limited health outcomes information exists for patients with mild to moderate plaque psoriasis (hereafter, referred to as psoriasis) prescribed topical treatment(s).

Aim: We evaluated clinical characteristics of patients with systemic-naïve mild to moderate psoriasis after topical use in the United States.

Methods: Data were drawn from 2017 to 2018 Adelphi Psoriasis Disease Specific Programme™, a point-in-time survey of physicians and adult psoriasis patients, capturing data on topical treatment at time of consultation prescribed to systemic-naïve patients with mild to moderate psoriasis (i.e. body surface area [BSA] ≤ 10%) at current treatment initiation. Patient clinical characteristics before/after topical use were evaluated descriptively.

Results: Among 304 patients (median age 43.0 years; 53.6% female), mean time since diagnosis was 60.9 months. After a mean 6.9 months on their current topical, 14.5% of patients achieved ≥75% BSA reduction, 38.9% ≥50% BSA reduction, and 50.2% no BSA reduction. Residual psoriasis symptoms included scaling (76.5%), inflamed skin (65.9%), and itching (60.4%). Most patients (71.2%) had residual psoriasis in special body areas: nails (92.3%), palmoplantar (78.9%), scalp (75.9%), and face (65.8%).

Conclusion: We found unmet need in topical treatment effectiveness in mild to moderate psoriasis patients, in terms of BSA reduction, symptoms, and special body areas affected.

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接受局部治疗的美国轻度至中度斑块型银屑病成年患者的现实世界健康结果
背景:轻度至中度斑块型银屑病(以下简称银屑病)患者局部治疗的健康结果信息有限。目的:我们评估在美国局部使用systemic-naïve轻至中度牛皮癣患者的临床特征。方法:数据来自2017年至2018年的Adelphi牛皮癣疾病特异性计划™,这是一项针对医生和成年牛皮癣患者的时间点调查,收集了目前治疗开始时对systemic-naïve轻度至中度牛皮癣患者(即体表面积[BSA]≤10%)进行会诊时的局部治疗数据。对局部用药前后患者的临床特征进行描述性评价。结果:304例患者中位年龄43.0岁;53.6%女性),平均诊断时间为60.9个月。在当前局部治疗平均6.9个月后,14.5%的患者BSA减少≥75%,38.9%的患者BSA减少≥50%,50.2%的患者BSA没有减少。残留牛皮癣症状包括脱屑(76.5%)、皮肤发炎(65.9%)和瘙痒(60.4%)。大多数患者(71.2%)在特殊部位有残留银屑病:指甲(92.3%)、掌足底(78.9%)、头皮(75.9%)和面部(65.8%)。结论:我们发现在轻度至中度银屑病患者的局部治疗效果方面,在BSA减少,症状和特殊的身体部位受到影响方面尚未得到满足。
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来源期刊
CiteScore
6.50
自引率
0.00%
发文量
145
审稿时长
6-12 weeks
期刊介绍: The Journal of Dermatological Treatment covers all aspects of the treatment of skin disease, including the use of topical and systematically administered drugs and other forms of therapy. The Journal of Dermatological Treatment is positioned to give dermatologists cutting edge information on new treatments in all areas of dermatology. It also publishes valuable clinical reviews and theoretical papers on dermatological treatments.
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