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Boxed warnings for dermatologic JAK inhibitors: are they standardized worldwide? 皮肤病用 JAK 抑制剂的盒装警告:是否在全球范围内统一?
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-18 DOI: 10.1080/09546634.2024.2403710
Shayla Nguyen, Nicholas Brownstone, John Koo
Published in Journal of Dermatological Treatment (Vol. 35, No. 1, 2024)
发表于《皮肤病治疗杂志》(第 35 卷第 1 期,2024 年)
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引用次数: 0
A review of biosimilars in psoriasis: impacts on efficacy, safety, access, and a first-hand look at biosimilar cost savings within the department of veterans affairs 牛皮癣生物仿制药综述:对疗效、安全性和可及性的影响,以及退伍军人事务部生物仿制药成本节约的第一手资料
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-15 DOI: 10.1080/09546634.2024.2402912
Rebecca Reese, Shiva Ram Nanavath, Jennifer Martin, Jeffrey B. Travers, Craig A. Rohan
Psoriasis is a chronic immune-mediated systemic disease whose treatment has been revolutionized due to the induction of monoclonal antibody-based biologics. However, access to these drugs has been ...
银屑病是一种慢性免疫介导的全身性疾病,由于单克隆抗体生物制剂的问世,银屑病的治疗发生了革命性的变化。然而,获得这些药物的途径却...
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引用次数: 0
Biodegradable polymers and platelet-rich plasma causing visual impairment: a literature review. 可降解聚合物和富血小板血浆导致视力损伤:文献综述。
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-12 DOI: 10.1080/09546634.2024.2402909
Kar Wai Alvin Lee,Lisa Kwin Wah Chan,Angela Wai Kay Lee,Cheuk Hung Lee,Jovian Wan,Kyu-Ho Yi
BACKGROUNDDermal fillers are widely used for facial rejuvenation and esthetic enhancement, offering temporary solutions for aging and volume loss. Despite their general safety, a rare but severe complication associated with these fillers is visual impairment, including blindness. This underscores the need for a thorough understanding of risks associated with various filler materials. Historical cases of blindness following filler injections date back to 1963, with increasing reports linked to the expansion of the cosmetic filler industry. While hyaluronic acid (HA) and autologous fat have been extensively studied, other fillers such as calcium hydroxylapatite and poly-l-lactic acid (PLLA) are less understood.OBJECTIVEThis systematic review aims to address gaps in the literature by providing a comprehensive overview of visual impairment caused by fillers other than HA and autologous fat. We systematically examine the prevalence, causes, clinical features, and treatment outcomes associated with these less common fillers.MATERIALS AND METHODSA comprehensive literature search was conducted across databases including PubMed, Scopus, and Google Scholar using terms related to visual impairment and dermal fillers. Studies published between 2014 and 2021, including observational studies and case reports, were included. Studies were selected based on predefined inclusion and exclusion criteria, and a PRISMA flow diagram was used to illustrate the study selection process.RESULTSThe review identifies and summarizes cases of visual impairment associated with calcium hydroxylapatite, poly-d,l-lactic acid (PDLLA), and PLLA fillers. Key findings reveal that visual impairment following these fillers is rare but can occur suddenly or within a few days of the procedure. Cases of delayed onset up to two weeks are also noted, emphasizing the need for extended post-procedure monitoring.DISCUSSIONThe review highlights unique insights into the risks associated with non-HA fillers, such as the heightened risk in the periorbital region and other facial areas. It explores mechanisms of complications, including retrograde flow of emboli leading to retinal ischemia. The discussion also covers emergency protocols and preventative measures, providing valuable guidance for managing and mitigating risks.CONCLUSIONSVisual impairment caused by fillers other than HA and autologous fat, while rare, represents a serious complication that requires careful attention. This review contributes new perspectives on the differential risks of various fillers, symptom onset variability, and anatomical risk factors. Emphasizing the importance of proper patient selection, technique, and monitoring, it calls for further research to better understand and prevent these complications, ultimately aiming for safer and more effective use of soft-tissue fillers.
背景皮肤填充剂被广泛用于面部年轻化和美容,为衰老和容积损失提供临时解决方案。尽管这些填充剂普遍安全,但与之相关的一种罕见但严重的并发症是视力损伤,包括失明。这就强调了彻底了解各种填充材料相关风险的必要性。注射填充剂后失明的历史病例可追溯到 1963 年,随着美容填充剂行业的发展,相关报告也越来越多。虽然对透明质酸(HA)和自体脂肪进行了广泛的研究,但对羟基磷灰石钙和聚乳酸(PLLA)等其他填充物的了解却较少。目的:本系统性综述旨在通过全面概述除透明质酸和自体脂肪以外的其他填充物导致的视力损伤,填补文献空白。我们系统地研究了与这些不常见填充剂相关的患病率、原因、临床特征和治疗结果。材料和方法我们使用与视力损伤和皮肤填充剂相关的术语,在包括 PubMed、Scopus 和 Google Scholar 在内的数据库中进行了全面的文献检索。纳入了 2014 年至 2021 年间发表的研究,包括观察性研究和病例报告。结果该综述确定并总结了与羟基磷灰石钙、聚对二甲苯乳酸(PDLLA)和聚对二甲苯乳酸(PLLA)填充剂相关的视力损伤病例。主要研究结果表明,使用这些填充剂后出现视力损伤的情况很少见,但可能会突然发生或在术后几天内发生。该综述强调了对非 HA 填充剂相关风险的独特见解,例如眶周和其他面部区域的高风险。它探讨了并发症的机制,包括导致视网膜缺血的栓子逆流。结论HA和自体脂肪以外的填充剂引起的视力损伤虽然罕见,但却是一种严重的并发症,需要认真对待。本综述对各种填充剂的不同风险、症状发作的可变性和解剖学风险因素提供了新的视角。文章强调了正确选择患者、技术和监测的重要性,呼吁进一步开展研究,以更好地了解和预防这些并发症,最终实现更安全、更有效地使用软组织填充剂的目标。
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引用次数: 0
Postoperative risk assessment of post-inflammatory hyperpigmentation and the efficacy of delayed prevention following 532 nm Q-switched Nd:YAG laser treatment of solar lentigines: a randomized controlled study. 532 nm Q 开关 Nd:YAG 激光治疗日光性色素沉着后的术后炎症性色素沉着风险评估和延迟预防的疗效:一项随机对照研究。
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-12 DOI: 10.1080/09546634.2024.2398768
Da-Hyun Kang,Sang-Min Choi,Yoonsung Lee,Man S Kim,Bark-Lynn Lew,Soon-Hyo Kwon
BACKGROUNDAlthough post-inflammatory hyperpigmentation (PIH) is a common adverse event following laser procedures, studies evaluating its risk remain limited.OBJECTIVETo analyze PIH risk after 532 nm Q-switched Nd:YAG laser (QSNYL) treatment for solar lentigines and examine the efficacy of triple combination cream (TCC) for its prevention.METHODSIn this single center, investigator-blinded, randomized controlled study, participants with solar lentigo either received TCC or emollient from 2 weeks post-QSNYL treatment. The occurrence of PIH was determined by three independent and blinded dermatologists. In vivo skin measurements and sun exposure questionnaires were examined to evaluate the risk of PIH.RESULTSA total of 28 patients with 67 solar lentigines were included in the analysis. In the control group, PIH occurred in 55.3% of the lesions. Risk factors for the occurrence of PIH were the increased erythema at weeks 2 (OR, 1.32; p = 0.035) and outdoor activity during 1-5 pm (OR, 8.10; p = 0.038). Treatment with TCC from 2 weeks post-QSNYL treatment significantly decreased the incidence of PIH (31.0% vs. 55.3%, p = 0.048).CONCLUSIONPost-laser erythema and outdoor activity at the daytime are prognostic factors for the occurrence of PIH. Administering TCC could be considered for the prevention of PIH in high-risk patients.
背景虽然炎症后色素沉着(PIH)是激光治疗后常见的不良反应,但评估其风险的研究仍然有限。目的分析 532 nm Q-switched Nd:YAG 激光(QSNYL)治疗日光性色斑后出现 PIH 的风险,并研究三重组合霜(TCC)对预防 PIH 的功效。方法 在这项单中心、研究者盲法、随机对照研究中,患有日光性白斑的参与者在接受 QSNYL 治疗后 2 周开始接受 TCC 或润肤霜治疗。PIH的发生率由三位独立的盲人皮肤科医生确定。结果共有 28 名患者的 67 个日光性白斑被纳入分析。在对照组中,55.3%的病变发生了 PIH。发生 PIH 的风险因素是第 2 周时红斑的增加(OR,1.32;p = 0.035)和下午 1-5 点的户外活动(OR,8.10;p = 0.038)。结论 激光术后红斑和白天的户外活动是 PIH 发生的预后因素。高危患者可考虑使用 TCC 预防 PIH。
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引用次数: 0
Exploring the effect of deucravacitinib in patients with palmoplantar pustular psoriasis. 探索德拉瓦替尼对掌跖脓疱型银屑病患者的疗效。
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-10 DOI: 10.1080/09546634.2024.2399220
David A De Luca,Cristian Papara,Tomasz Hawro,Diamant Thaçi,Sascha Ständer
INTRODUCTIONPalmoplantar pustular psoriasis (PPPP) is a chronic inflammatory skin disorder characterized by sterile pustules on the palms and soles, significantly impacting patients' quality of life. The pathogenesis of PPPP involves intricate interactions between immune dysregulation, environmental triggers, and genetic predisposition. The treatment of PPPP is challenging, and there is a need for effective and safe treatment options for patients.OBJECTIVEWe evaluated the efficacy and safety of deucravacitinib, a novel oral selective allosteric inhibitor of tyrosine kinase 2 (TYK2), in treating refractory PPPP.MATERIAL AND METHODSA retrospective analysis was conducted on five patients treated with deucravacitinib 6 mg/day, with clinical assessments at weeks 0, 4, and 16.RESULTSWhile initial worsening was observed in most patients, three showed improvement by week 16. One patient improved with the addition of methotrexate. Treatment was discontinued in two patients after week 16. Adverse effects were primarily viral and bacterial infections, and no serious adverse events occurred.CONCLUSIONCurrent therapeutic options for PPPP are limited, necessitating exploration of novel treatments. Deucravacitinib's mechanism of action, targeting TYK2, could show promise in PPPP management. However, its efficacy and safety in this specific condition require further investigation through larger, randomized controlled trials.
引言 掌跖脓疱性银屑病(PPPP)是一种慢性炎症性皮肤病,以手掌和足底出现无菌性脓疱为特征,严重影响患者的生活质量。脓疱型银屑病的发病机制涉及免疫调节失调、环境诱因和遗传易感性之间错综复杂的相互作用。我们评估了新型口服酪氨酸激酶 2(TYK2)选择性异位抑制剂 deucravacitinib 治疗难治性 PPPP 的疗效和安全性。材料和方法对5名接受6毫克/天德拉瓦替尼治疗的患者进行了回顾性分析,并在第0周、第4周和第16周进行了临床评估。结果虽然大多数患者的病情最初都有所恶化,但有3名患者的病情在第16周时有所改善。一名患者在加用甲氨蝶呤后病情有所好转。两名患者在第 16 周后停止了治疗。不良反应主要是病毒和细菌感染,没有发生严重不良事件。Deucravacitinib以TYK2为靶点的作用机制有望用于PPPP的治疗。然而,它在这种特殊情况下的疗效和安全性还需要通过更大规模的随机对照试验来进一步研究。
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引用次数: 0
Report of successful treatment of follicular occlusion triad with adalimumab and research progress on biologic therapy for follicular occlusion triad 阿达木单抗成功治疗毛囊闭塞三联征的报告以及毛囊闭塞三联征生物疗法的研究进展
IF 2.9 4区 医学 Q2 DERMATOLOGY Pub Date : 2024-09-09 DOI: 10.1080/09546634.2024.2391451
Ruiling Jia, Qingchun Diao, Yuyi Wang
Purpose: This article aims to present a case report of a patient with Follicular occlusion triad (FOT) who achieved successful disease control with adalimumab combined with isotretinoin and provide...
目的:本文旨在介绍一例毛囊闭塞三联征(FOT)患者的病例报告,该患者使用阿达木单抗联合异维A酸成功控制了病情。
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引用次数: 0
Statement of retraction: evidence-based clinical practice guidelines for the management of psoriasis: systematic review, critical appraisal, and quality assessment with the AGREE II instrument 撤回声明:以证据为基础的银屑病管理临床实践指南:使用 AGREE II 工具进行系统性回顾、批判性评价和质量评估
IF 2.9 4区 医学 Q1 Medicine Pub Date : 2024-04-29 DOI: 10.1080/09546634.2024.2334685
Published in Journal of Dermatological Treatment (Vol. 35, No. 1, 2024)
发表于《皮肤病治疗杂志》(第 35 卷第 1 期,2024 年)
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引用次数: 0
Lebrikizumab monotherapy impacts on quality of life scores through improved itch and sleep interference in two Phase 3 trials 在两项 3 期试验中,通过改善瘙痒和睡眠干扰,莱布珠单抗单药疗法对生活质量评分产生了影响
IF 2.9 4区 医学 Q1 Medicine Pub Date : 2024-04-28 DOI: 10.1080/09546634.2024.2329240
Jennifer Soung, Sonja Ständer, Jan Gutermuth, Ignasi Pau-Charles, Zach Dawson, Fan Emily Yang, Luna Sun, Evangeline Pierce, Hany Elmaraghy, Linda Stein-Gold
Lebrikizumab improved itch, interference of itch on sleep, and quality of life (QoL) in patients with moderate-to-severe atopic dermatitis (AD), in two Phase 3 trials at 16 weeks compared to placeb...
在两项三期临床试验中,与安慰剂相比,Lebrikizumab可在16周内改善中重度特应性皮炎(AD)患者的瘙痒、瘙痒对睡眠的干扰以及生活质量(QoL)。
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引用次数: 0
Real-world outcomes and drug survival of brodalumab: results from the German Psoriasis Registry PsoBest 布达鲁单抗的实际疗效和药物存活率:德国银屑病登记 PsoBest 的结果
IF 2.9 4区 医学 Q1 Medicine Pub Date : 2024-04-18 DOI: 10.1080/09546634.2024.2340107
Lisa Schaeffer, Nesrine Ben-Anaya, Christina Sorbe, Stephan Jeff Rustenbach, Ulrich Mrowietz, Matthias Augustin
Brodalumab, a human monoclonal antibody that targets interleukin-17 receptor A (IL-17RA), is approved in the US and EU for treatment of adults with moderate-to-severe plaque psoriasis. Although bro...
Brodalumab是一种靶向白细胞介素-17受体A(IL-17RA)的人类单克隆抗体,已在美国和欧盟获批用于治疗成人中重度斑块状银屑病。虽然布罗...
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引用次数: 0
Tofacitinib for managing granuloma formation after dermal filler injection: three case reports and literature review 托法替尼用于控制皮肤填充剂注射后肉芽肿的形成:三份病例报告和文献综述
IF 2.9 4区 医学 Q1 Medicine Pub Date : 2024-04-18 DOI: 10.1080/09546634.2024.2338281
Jieyi Wang, Zhuoxuan Chen, Lin Wu, Yan Liao, Bo Yu
Granuloma formation is an uncommon and persistent skin inflammatory condition caused by the injection of dermal fillers. The exact cause of this reaction is not well understood, but it may be assoc...
肉芽肿的形成是一种不常见的持续性皮肤炎症,由注射皮肤填充剂引起。这种反应的确切原因还不十分清楚,但可能与以下因素有关...
{"title":"Tofacitinib for managing granuloma formation after dermal filler injection: three case reports and literature review","authors":"Jieyi Wang, Zhuoxuan Chen, Lin Wu, Yan Liao, Bo Yu","doi":"10.1080/09546634.2024.2338281","DOIUrl":"https://doi.org/10.1080/09546634.2024.2338281","url":null,"abstract":"Granuloma formation is an uncommon and persistent skin inflammatory condition caused by the injection of dermal fillers. The exact cause of this reaction is not well understood, but it may be assoc...","PeriodicalId":15639,"journal":{"name":"Journal of Dermatological Treatment","volume":"13 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Dermatological Treatment
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