Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Magnesium research Pub Date : 2022-04-01 DOI:10.1684/mrh.2022.0503

Sara Saba, Fakhrudin Faizi, Mojtaba Sepandi, Batool Nehrir

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Abstract

Objective: This study aimed to evaluate the effect of magnesium supplementation on anxiety, depression and sleep quality of patients after openheart surgery.

Materials and methods: Based on a clinical trial, 60 candidates for open-heart surgery were separated into control and intervention groups. In the intervention group, 500 mg of magnesium was administered daily in the form of two 250-mg magnesium oxide tablets for five days, and routine care was performed in the control group. Patients’ demographic information and assessment based on the Hospital Anxiety and Depression Scale (HADS) and Petersburg Sleep Quality Inventory (PSQI) were documented at the beginning of the study, after surgery and endotracheal intubation, and at the end of the study. Data were statistically analysed using Stata software version 13.

Results: After the intervention, the mean level of magnesium in the intervention group was significantly higher (p=0.001). At the end of the study, the mean level of anxiety and depression was significantly lower in the intervention group than the control group (p=0.007), moreover, mean sleep quality improved in the intervention group (8.3 ± 2.1) compared to the control group (10.3 ± 2.0) (p=0.001).

Conclusion: Due to the effects of magnesium supplementation in patients after heart surgery, it is recommended that this supplement be included in the treatment plan in order to prevent anxiety and depression in these patients after surgery and improve their quality of sleep.

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短期补镁对心内直视术后患者焦虑、抑郁及睡眠质量的影响

目的:探讨补充镁对心脏直视手术后患者焦虑、抑郁及睡眠质量的影响。材料与方法:在临床试验的基础上，将60例心内直视手术候选者分为对照组和干预组。干预组每日给予500 mg镁，以2片250 mg氧化镁的形式给予5天，对照组给予常规护理。在研究开始时、手术和气管插管后以及研究结束时记录患者的人口统计信息和基于医院焦虑和抑郁量表(HADS)和Petersburg睡眠质量量表(PSQI)的评估。数据采用Stata软件第13版进行统计分析。结果:干预后，干预组镁的平均水平显著高于对照组(p=0.001)。研究结束时，干预组患者焦虑、抑郁的平均水平显著低于对照组(p=0.007)，睡眠质量的平均水平(8.3±2.1)显著高于对照组(10.3±2.0)(p=0.001)。结论:鉴于补充镁对心脏手术后患者的影响，建议将其纳入治疗方案，以预防心脏手术后患者的焦虑和抑郁，改善其睡眠质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.