[Extremity soft tissue sarcoma: does surgical margin impact survival?]

IF 0.5 4区 医学 Q4 SURGERY Cirugia Y Cirujanos Pub Date : 2023-12-07 DOI:10.24875/CIRU.22000202
Rafael Medrano-Guzmán, Moises Brener-Chaoul, Luis E García-Ríos, Marisol Luna-Castillo
{"title":"[Extremity soft tissue sarcoma: does surgical margin impact survival?]","authors":"Rafael Medrano-Guzmán, Moises Brener-Chaoul, Luis E García-Ríos, Marisol Luna-Castillo","doi":"10.24875/CIRU.22000202","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To define the impact of surgical margins on local recurrence (LR), distant recurrence (DR) and overall survival (OS) in patients with soft tissue sarcomas of the extremities (eSTS).</p><p><strong>Method: </strong>Patients treated for a primary eSTS from 2006 to 2010 were analyzed. Rates of local recurrence, distant recurrence, and overall survival were estimated using the Kaplan-Meier method. The association of possible prognostic factors such as local recurrence, metastasis, and survival was performed using the Cox proportional hazards model.</p><p><strong>Results: </strong>128 patients were analyzed. The surgical margins were positive (R1 resection) in 22.7% and negative in 77.3%. The LR was 27%, the DR was 13% (70% of the population was free of disease at 5 years) and OS at 5 years was 84%. The prognostic factors for OS at 5 years were clinical stage, type and histological grade. The surgical margin had no impact on OS.</p><p><strong>Conclusions: </strong>Although an adequate oncological resection cannot be underestimated, this should be considered in the decision of the optimal treatment of eSTS when amputation or significant functional impairment of the limb is required to obtain negative surgical margins.</p>","PeriodicalId":50990,"journal":{"name":"Cirugia Y Cirujanos","volume":" ","pages":"810-815"},"PeriodicalIF":0.5000,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cirugia Y Cirujanos","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/CIRU.22000202","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To define the impact of surgical margins on local recurrence (LR), distant recurrence (DR) and overall survival (OS) in patients with soft tissue sarcomas of the extremities (eSTS).

Method: Patients treated for a primary eSTS from 2006 to 2010 were analyzed. Rates of local recurrence, distant recurrence, and overall survival were estimated using the Kaplan-Meier method. The association of possible prognostic factors such as local recurrence, metastasis, and survival was performed using the Cox proportional hazards model.

Results: 128 patients were analyzed. The surgical margins were positive (R1 resection) in 22.7% and negative in 77.3%. The LR was 27%, the DR was 13% (70% of the population was free of disease at 5 years) and OS at 5 years was 84%. The prognostic factors for OS at 5 years were clinical stage, type and histological grade. The surgical margin had no impact on OS.

Conclusions: Although an adequate oncological resection cannot be underestimated, this should be considered in the decision of the optimal treatment of eSTS when amputation or significant functional impairment of the limb is required to obtain negative surgical margins.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[肢体软组织肉瘤:手术切缘对存活率有影响吗?]
目的:确定手术切缘对四肢软组织肉瘤(eSTS)患者局部复发(LR)、远处复发(DR)和总生存率(OS)的影响:明确手术切缘对四肢软组织肉瘤(eSTS)患者局部复发(LR)、远处复发(DR)和总生存率(OS)的影响:方法:对2006年至2010年接受原发性肢端软组织肉瘤治疗的患者进行分析。采用卡普兰-梅耶法估算了局部复发率、远处复发率和总生存率。采用考克斯比例危险模型对局部复发、转移等可能的预后因素与生存率之间的关系进行分析:分析了 128 例患者。22.7%的患者手术切缘为阳性(R1切除),77.3%为阴性。LR为27%,DR为13%(70%的患者在5年后无疾病),5年后的OS为84%。5年生存率的预后因素包括临床分期、类型和组织学分级。手术切缘对OS没有影响:尽管不能低估充分的肿瘤切除,但在决定 eSTS 的最佳治疗方法时,如果需要截肢或肢体功能严重受损才能获得阴性手术切缘,则应考虑到这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Cirugia Y Cirujanos
Cirugia Y Cirujanos 医学-外科
CiteScore
0.90
自引率
20.00%
发文量
207
审稿时长
6-12 weeks
期刊介绍: Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.
期刊最新文献
Clinical outcomes and radiological assessment of vascular anatomy in patients who underwent D3 left hemicolectomy. A model to determine factors influencing intraoperative complications in sleeve gastrectomy. [Extremity soft tissue sarcoma: does surgical margin impact survival?] Relación preoperatoria de neutrófilos a proteína C reactiva como predictor de complicaciones posoperatorias del cáncer de pancreas ¿La vía de señalización de sonic hedgehog desempeña un papel en el mecanismo antirreflujo de la vejiga en los niños?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1