Protective effects of Erythronium japonicum and Corylopsis coreana Uyeki extracts against 1,3-dichloro-2-propanol-induced hepatotoxicity in rats

Q3 Immunology and Microbiology Applied Microscopy Pub Date : 2020-12-02 DOI:10.1186/s42649-020-00049-0

Seunghyun Kim, Hee-Ock Boo, Taeho Ahn, Chun-Sik Bae

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引用次数: 2

Abstract

Erythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

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丹参和山茱萸提取物对1,3-二氯-2-丙醇所致大鼠肝毒性的保护作用

日本赤藓(Erythronium japonicum)和韩国冬梅(Corylopsis coreana Uyeki, Korean winter hazel)已被证明能显著降低1,3-二氯-2-丙醇(1,3- dcp)诱导的HuH7人肝细胞中活性氧的产生和CYP2E1的活性。本研究在前人研究的基础上，进一步探讨了日本藤和山茱萸提取物对1,3- dcp致大鼠肝损伤的保护作用。用这些提取物预处理大鼠，减轻了体重的下降，降低了1,3- dcp引起的血清中天冬氨酸转氨酶和丙氨酸转氨酶等肝脏酶的催化活性升高。此外，用提取物处理可以恢复1,3- dcp诱导的大鼠肝脏中抗氧化酶活性的下降，如超氧化物歧化酶和过氧化氢酶的活性。组织病理学研究也强烈支持酶活性的结果。这些结果提示，日本藤和山茱萸提取物可能是一种减轻1,3- dcp引起的动物肝损伤的药物。

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来源期刊

Applied Microscopy Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Applied Microscopy is a peer-reviewed journal sponsored by the Korean Society of Microscopy. The journal covers all the interdisciplinary fields of technological developments in new microscopy methods and instrumentation and their applications to biological or materials science for determining structure and chemistry. ISSN: 22875123, 22874445.