Structural characterization of adenine moiety in functional RNA molecules.

Abstract

RNA molecules express the specific structure containing A-form helices and non-helical regions, such as loops and bulges. The adenosine moiety plays a key role in helical packing and/or loop and/or bulge interactions. It is well known as A-platform, tetraloop, and A-minor motif. For the formation of these motifs, there are specific interactions to the adjacent RNA segments and/or protein and/or metal ions beside the specific base sequences. The database focusing on adenine's structural roles, structural information about the assemblage and the space distribution of base moieties can be a useful tool. The user can obtain the selected list with the several descriptors including kink parameters for the structure definition and sequence properties. In addition to this nucleic acid system, RNA-drug related compound system would be included.