Gene-Environment Interactions: My Unique Journey.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-10-03 DOI:10.1146/annurev-pharmtox-022323-082311
Daniel W Nebert
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Abstract

I am deeply honored to be invited to write this scientific autobiography. As a physician-scientist, pediatrician, molecular biologist, and geneticist, I have authored/coauthored more than 600 publications in the fields of clinical medicine, biochemistry, biophysics, pharmacology, drug metabolism, toxicology, molecular biology, cancer, standardized gene nomenclature, developmental toxicology and teratogenesis, mouse genetics, human genetics, and evolutionary genomics. Looking back, I think my career can be divided into four distinct research areas, which I summarize mostly chronologically in this article: (a) discovery and characterization of the AHR/CYP1 axis, (b) pharmacogenomics and genetic prediction of response to drugs and other environmental toxicants, (c) standardized drug-metabolizing gene nomenclature based on evolutionary divergence, and (d) discovery and characterization of the SLC39A8 gene encoding the ZIP8 metal cation influx transporter. Collectively, all four topics embrace gene-environment interactions, hence the title of my autobiography.

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基因与环境的相互作用:我独特的旅程。
我很荣幸能受邀撰写这本科学自传。作为一名医生、儿科医生、分子生物学家和遗传学家,我在临床医学、生物化学、生物物理学、药理学、药物代谢、毒理学、分子生物学、癌症、标准化基因命名法、发育毒理学和畸形发生、小鼠遗传学、人类遗传学和进化基因组学等领域撰写/合著了600多篇出版物。回顾过去,我认为我的职业生涯可以分为四个不同的研究领域,我在这篇文章中主要按时间顺序总结了这些领域:(a)AHR/CYP1轴的发现和表征,(b)药物基因组学和对药物和其他环境毒物反应的遗传预测,(c)基于进化差异的标准化药物代谢基因命名,和(d)编码ZIP8金属阳离子内流转运蛋白的SLC39A8基因的发现和表征。总的来说,这四个主题都包含了基因与环境的相互作用,因此我的自传命名为。《药理学与毒理学年度评论》第64卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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