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{"title":"Evaluation of Atopic Dermatitis Improvement Caused by Low-Level, Low-Frequency Pulsed Electromagnetic Fields","authors":"Jun-Young Kim, Ji-Young Lee, Ja-Woo Lee, Soo-Kyung Lee, Chang-Soon Park, Se-Jung Yang, Yong-Heum Lee","doi":"10.1002/bem.22405","DOIUrl":null,"url":null,"abstract":"<p>This study aimed to evaluate the effectiveness of using low-level, low-frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Twenty 6-week-old hairless mice were randomly divided into Normal (<i>n</i> = 5), PEMF 15 Hz (<i>n</i> = 5), PEMF 75 Hz (<i>n</i> = 5), and Sham (<i>n</i> = 5) groups. Following the onset of atopic dermatitis symptoms, PEMF groups (15 and 75 Hz) were stimulated with LLLF_PEMF (15 mT) for 8 h per day for 1 week. Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (<i>P</i> < 0.05), but these differences were not visually obvious. While both the PEMF and Sham groups had atopic dermatitis lesions, lesion size was significantly smaller in the two PEMF groups than in the Sham group (<i>P</i> < 0.001). Additionally, changes in epithelial thickness because of skin inflammation significantly decreased for both PEMF groups, compared with the Sham group (<i>P</i> < 0.001). In conclusion, these results suggest that PEMF stimulation in vivo triggers electro-chemical reactions that affect immune response. © 2022 Bioelectromagnetics Society.</p>","PeriodicalId":8956,"journal":{"name":"Bioelectromagnetics","volume":"43 4","pages":"268-277"},"PeriodicalIF":1.8000,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectromagnetics","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bem.22405","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
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Abstract
This study aimed to evaluate the effectiveness of using low-level, low-frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Twenty 6-week-old hairless mice were randomly divided into Normal (n = 5), PEMF 15 Hz (n = 5), PEMF 75 Hz (n = 5), and Sham (n = 5) groups. Following the onset of atopic dermatitis symptoms, PEMF groups (15 and 75 Hz) were stimulated with LLLF_PEMF (15 mT) for 8 h per day for 1 week. Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (P < 0.05), but these differences were not visually obvious. While both the PEMF and Sham groups had atopic dermatitis lesions, lesion size was significantly smaller in the two PEMF groups than in the Sham group (P < 0.001). Additionally, changes in epithelial thickness because of skin inflammation significantly decreased for both PEMF groups, compared with the Sham group (P < 0.001). In conclusion, these results suggest that PEMF stimulation in vivo triggers electro-chemical reactions that affect immune response. © 2022 Bioelectromagnetics Society.
低水平、低频脉冲电磁场对特应性皮炎改善的评价
本研究旨在评价低水平、低频脉冲电磁场(LLLF_PEMF)刺激对2,4-二硝基氯苯(DNCB)诱发的特应性皮炎的疗效。将20只6周龄无毛小鼠随机分为正常组(n = 5)、PEMF 15 Hz组(n = 5)、PEMF 75 Hz组(n = 5)和Sham组(n = 5)。在特应性皮炎症状发作后，用15和75 Hz的LLLF_PEMF (15 mT)刺激PEMF组，每天8小时，持续1周。感官评价分析显示，PEMF 15 Hz组与Sham组之间存在显著差异(P < 0.05)，但这些差异在视觉上并不明显。虽然PEMF组和Sham组都有特应性皮炎病变，但两个PEMF组的病变大小明显小于Sham组(P < 0.001)。此外，与Sham组相比，两个PEMF组因皮肤炎症引起的上皮厚度变化显著减少(P < 0.001)。总之，这些结果表明，在体内刺激PEMF会引发影响免疫反应的电化学反应。©2022生物电磁学学会。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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