Recent advances on the role of monoamine oxidases in cardiac pathophysiology.

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Basic Research in Cardiology Pub Date : 2023-10-04 DOI:10.1007/s00395-023-01012-2
Nina Kaludercic, Ruth Jepchirchir Arusei, Fabio Di Lisa
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Abstract

Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen species (ROS). However, the individual contribution of different mitochondrial processes independently of bioenergetics remains elusive and clinical treatments unavailable. A notable exception to this complexity is found in the case of monoamine oxidases (MAOs). Unlike other ROS-producing enzymes, especially within mitochondria, MAOs possess a distinct combination of defined molecular structure, substrate specificity, and clinically accessible inhibitors. Another significant aspect of MAO activity is the simultaneous generation of hydrogen peroxide alongside highly reactive aldehydes and ammonia. These three products synergistically impair mitochondrial function at various levels, ultimately jeopardizing cellular metabolic integrity and viability. This pathological condition arises from exacerbated MAO activity, observed in many cardiovascular diseases, thus justifying the exploration of MAO inhibitors as effective cardioprotective strategy. In this context, we not only summarize the deleterious roles of MAOs in cardiac pathologies and the positive effects resulting from genetic or pharmacological MAO inhibition, but also discuss recent findings that expand our understanding on the role of MAO in gene expression and cardiac development.

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单胺类氧化酶在心脏病理生理学中作用的最新进展。
许多生理和病理作用都归因于线粒体活性氧(ROS)的形成。然而,独立于生物能量学的不同线粒体过程的个体贡献仍然难以捉摸,临床治疗也不可用。这种复杂性的一个显著例外是在单胺氧化酶(MAOs)的情况下发现的。与其他产生ROS的酶不同,特别是在线粒体内,MAOs具有明确的分子结构、底物特异性和临床可获得的抑制剂的独特组合。MAO活性的另一个重要方面是同时产生过氧化氢以及高反应性的醛和氨。这三种产物在不同水平上协同损害线粒体功能,最终危害细胞代谢的完整性和活力。这种病理状况源于在许多心血管疾病中观察到的MAO活性加剧,因此证明了MAO抑制剂作为有效的心脏保护策略的探索是合理的。在这种情况下,我们不仅总结了MAO在心脏病理中的有害作用以及遗传或药理学抑制MAO产生的积极影响,还讨论了最近的发现,这些发现扩大了我们对MAO在基因表达和心脏发育中作用的理解。
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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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