A Salmonella Pullorum outbreak with neurological signs in adult layers and outbreak investigation using whole genome sequencing.

IF 2.5 2区农林科学 Q1 VETERINARY SCIENCES Avian Pathology Pub Date : 2024-02-01 Epub Date: 2023-12-19 DOI:10.1080/03079457.2023.2268027

Robert Jan Molenaar, Remco Dijkman, Christiaan Ter Veen, Annet Heuvelink, Fiona van Kaam, Marieke Augustijn, Anneke Feberwee

引用次数: 1

Abstract

Research highlights: Cerebral granulomas are associated with nervous signs in Salmonella Pullorum outbreak.Bone marrow is also a recommended tissue for isolation of Salmonella Pullorum.Rapid plate agglutination test detects Pullorum antibodies in a vaccinated flock.Phylogenetic analysis showed clonality of isolates within the outbreak.

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在成年蛋鸡中爆发具有神经系统症状的白氏沙门氏菌疫情，并使用全基因组测序进行疫情调查。

本报告描述了在65周龄（W）的荷兰蛋鸡群中爆发的肠炎沙门氏菌亚种肠炎血清型Gallinarum生物型Pullorum（SP），显示出死亡率增加、产蛋量减少和神经系统症状。在饲养期间，该群被接种了三次肠炎沙门氏菌和鼠伤寒沙门氏菌活疫苗。在71 W时，随着死亡率达到峰值，应用SG 9R活疫苗。76 W时，死亡率下降，卵子产量稳定，但没有恢复到正常水平。经常进行尸检、组织学、细菌学和血清学检查。病禽和死禽的大体表现为肝脾肿大和卵巢炎。SP经常从肝、脾、卵巢和骨髓中分离，不同器官的分离率差异不大。有神经系统症状的鸟类的组织学检查和免疫染色显示，在沙门氏菌存在的情况下出现了大脑肉芽肿。以前的沙门氏菌疫苗接种不会妨碍使用商业快速平板凝集试验检测特异性SP抗体（血清稀释度≥1:8时呈阳性）。在85 W时，对40只临床健康的鸟类进行了调查，其中3只出现卵巢病变，这解释了卵子生产没有恢复正常。这些鸟有抗SP的抗体，表明与细菌有过接触，但无法通过培养证实其携带状态。系统发育分析表明，此次疫情中的SP分离株是克隆的，与以往疫情中的分离株不同。研究重点：与布鲁伦沙门氏菌爆发中的神经症状相关的脑肉芽肿骨髓也是分离布鲁伦沙门杆菌的推荐组织快速平板凝集试验在接种的絮凝物中检测布鲁伦抗体系统发育分析显示爆发中分离株的克隆性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.