Characterization of theory of mind performance in patients with myotonic dystrophy type 1

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES Cortex Pub Date : 2023-09-09 DOI:10.1016/j.cortex.2023.07.008

Jean-Baptiste Davion , Céline Tard , Grégory Kuchcinski , Loren Fragoso , Amina Wilu-Wilu , Pierre Maurage , Sylvie Nguyen The Tich , Luc Defebvre , Fabien D'Hondt , Xavier Delbeuck

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Abstract

Introduction

Myotonic dystrophy type 1 (DM1) is associated with motor dysfunction as well as psychological and cognitive impairments, including altered social cognition. Theory of mind (ToM) impairments have been reported in this disease but their nature and their cognitive/cerebral correlates have yet to be determined.

Methods

Fifty DM1 patients and 50 healthy controls were assessed using the Movie for the Assessment of Social Cognition, which quantifies impairments in affective and cognitive components of ToM through the depiction of everyday situations. We also measured the study participants' cognitive, behavioral and social abilities, quality of life, and brain MRI characteristics.

Results

DM1 patients presented a significant impairment in ToM performance compared to controls (p < .001). The patients' errors were related to hypomentalizations (p < .001 vs controls) but not to hypermentalizations (p = .95). The affective component was affected (p < .001 vs controls) but not the cognitive component (p = .09). The ToM impairment was associated with demographic variables (older age and a lower educational level), genetic findings (a larger CTG triplets repeat expansion) and cognitive scores (slower information processing speed). Associations were also found with brain MRI variables (lower white matter and supratentorial volumes) but not with behavioral or social variables.

Discussion

DM1 patients display a ToM impairment, characterized by predominant hypomentalizations concerning the affective component. This impairment might result from structural brain abnormalities observed in DM1.

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1型强直性肌营养不良患者心理表现理论的特点。

引言：1型肌营养不良（DM1）与运动功能障碍以及心理和认知障碍有关，包括社会认知的改变。据报道，这种疾病存在心理理论障碍，但其性质及其认知/大脑相关性尚待确定。方法：使用社会认知评估电影对50名DM1患者和50名健康对照进行评估，该电影通过描述日常情况来量化ToM的情感和认知成分的损伤。我们还测量了研究参与者的认知、行为和社交能力、生活质量以及大脑MRI特征。结果：与对照组相比，DM1患者的ToM表现出显著的障碍（p讨论：DM1患者表现出ToM障碍，其特征是主要的情感成分的心理障碍。这种障碍可能是由DM1中观察到的大脑结构异常引起的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.