A thalamo-parietal cortex circuit is critical for place-action coordination

IF 2.4 3区 医学 Q3 NEUROSCIENCES Hippocampus Pub Date : 2023-10-09 DOI:10.1002/hipo.23578
Christine M. Simmons, Shawn C. Moseley, Jordan D. Ogg, Xinyu Zhou, Madeline Johnson, Wei Wu, Benjamin J. Clark, Aaron A. Wilber
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Abstract

The anterior and lateral thalamus (ALT) contains head direction cells that signal the directional orientation of an individual within the environment. ALT has direct and indirect connections with the parietal cortex (PC), an area hypothesized to play a role in coordinating viewer-dependent and viewer-independent spatial reference frames. This coordination between reference frames would allow an individual to translate movements toward a desired location from memory. Thus, ALT-PC functional connectivity would be critical for moving toward remembered allocentric locations. This hypothesis was tested in rats with a place-action task that requires associating an appropriate action (left or right turn) with a spatial location. There are four arms, each offset by 90°, positioned around a central starting point. A trial begins in the central starting point. After exiting a pseudorandomly selected arm, the rat had to displace the correct object covering one of two (left versus right) feeding stations to receive a reward. For a pair of arms facing opposite directions, the reward was located on the left, and for the other pair, the reward was located on the right. Thus, each reward location had a different combination of allocentric location and egocentric action. Removal of an object was scored as correct or incorrect. Trials in which the rat did not displace any objects were scored as “no selection” trials. After an object was removed, the rat returned to the center starting position and the maze was reset for the next trial. To investigate the role of the ALT-PC network, muscimol inactivation infusions targeted bilateral PC, bilateral ALT, or the ALT-PC network. Muscimol sessions were counterbalanced and compared to saline sessions within the same animal. All inactivations resulted in decreased accuracy, but only bilateral PC inactivations resulted in increased non selecting, increased errors, and longer latency responses on the remaining trials. Thus, the ALT-PC circuit is critical for linking an action with a spatial location for successful navigation.

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丘脑-顶叶皮层回路对位置-动作协调至关重要。
丘脑前部和外侧(ALT)包含头部方向细胞,这些细胞指示个体在环境中的方向取向。ALT与顶叶皮层(PC)有直接和间接的联系,该区域被假设在协调观众依赖和观众独立的空间参考系中发挥作用。参考系之间的这种协调将允许个体将运动从记忆中转换到期望的位置。因此,ALT-PC功能连接对于向记忆中的异地位置移动至关重要。这一假设在大鼠身上进行了测试,该任务需要将适当的动作(左转或右转)与空间位置联系起来。有四个臂,每个臂偏移90°,位于中心起点周围。审判从中心起点开始。在离开伪随机选择的手臂后,大鼠必须移动覆盖两个(左与右)喂食站之一的正确物体才能获得奖励。对于面向相反方向的一对手臂,奖励位于左侧,而对于另一对,奖励位于右侧。因此,每个奖励地点都有不同的异地中心地点和自我中心行动的组合。移除物体被视为正确或不正确。大鼠没有移动任何物体的试验被评定为“无选择”试验。移除物体后,大鼠返回中心起始位置,并重置迷宫以进行下一次试验。为了研究ALT-PC网络的作用,麝香醇灭活输注靶向双侧PC、双侧ALT或ALT-PC网。在同一动物体内,肌肉注射平衡并与生理盐水注射进行比较。所有失活均导致准确性下降,但只有双侧PC失活导致剩余试验中非选择增加、错误增加和延迟反应延长。因此,ALT-PC电路对于将动作与成功导航的空间位置联系起来至关重要。
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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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