Effect of age and sex on hematological and biochemical parameters in Chinese rhesus monkeys (Macaca mulatta) anesthetized with ketamine

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES Journal of Medical Primatology Pub Date : 2023-10-08 DOI:10.1111/jmp.12677

Gaohong Zhu, Xuedan Liu, Jiaojiao Feng, Yun Deng, Yijiang Li, Qionglin Ma, Lilin Chen, Yulin Su, An Ping, Fei Xie, Tinghua Wang, Longbao Lv

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Abstract

Objective

Rhesus monkeys are increasingly used in biomedical research, which makes their hematological and biochemical parameters increasingly important in preclinical research. Since age and sex can influence blood parameters, establishing reference intervals for such parameters based on age and sex becomes along with identifying the effect of age and sex on those parameters.

Methods

A total of 1385 healthy Chinese rhesus monkeys (548 males and 837 females) anesthetized with ketamine were selected and segregated by age (six groups) and sex. A total of 21 hematological and 26 biochemical parameters were measured, and the effects of age and sex were analyzed.

Results

We established baseline indices for hematological and biochemical parameters based on age and sex, separately, and observed significant impacts of age, sex, and age-sex interactions on blood parameters. Among different age groups, significant differences were found in WBC, NEUT%, LYM%, EO%, LYM#, EO#, MCV, RDW-CV, PLT, MPV, PDW, PCT, TP, Alb, GLB, A/G, ALT, AST, ALP, TBIL, GGT, BUN, Cre, GLU, CK, TRIG, LDL, HCY, IL-6 FOL, Vit B12, VIT D-T, PTH, and AMH. Additionally, significant differences were observed in RBC, HGB, HCT, MPV, Alb, BUN, Cre, GLU, CHOL, TRIG, HDL, LDL, HCY, and VIT D-T between the two sexes. An age-sex interaction exerted a significant effect on WBC, NEUT#, MCV, MCHC, PDW, GLB, ALP, Cre, CHOL, TRIG, HDL, LDL, HCY, IL-6, Vit B12, VIT D-T. However, neither age, sex, and age-sex interactions exerted significant effects on MO%, MOMO#, MCH, RDW-SD, CRP, and CT.

Conclusion

Our study investigated the blood parameters of rhesus monkeys to provide a reference basis for rhesus monkey-related scientific experimental research.

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年龄和性别对氯胺酮麻醉的中国恒河猴血液学和生化参数的影响。

目的：恒河猴在生物医学研究中的应用越来越多，这使得其血液学和生化参数在临床前研究中越来越重要。由于年龄和性别会影响血液参数，因此根据年龄和性别为这些参数建立参考区间，就可以识别年龄和性别对这些参数的影响。方法：选择1385只健康的中国恒河猴（548只雄性和837只雌性），用氯胺酮麻醉，并按年龄（6组）和性别进行分离。共测量了21项血液学和26项生化参数，并分析了年龄和性别的影响。结果：我们分别根据年龄和性别建立了血液学和生化参数的基线指标，并观察到年龄、性别和年龄-性别相互作用对血液参数的显著影响。在不同年龄组中，WBC、NEUT%、LYM%、EO%、LYM#、EO#、MCV、RDW-CV、PLT、MPV、PDW、PCT、TP、Alb、GLB、A/G、ALT、AST、ALP、TBIL、GGT、BUN、Cre、GLU、CK、TRIG、LDL、HCY、IL-6 FOL、Vit B12、Vit D-T、PTH和AMH存在显著差异。此外，在RBC、HGB、HCT、MPV、Alb、BUN、Cre、GLU、CHOL、TRIG、HDL、LDL、HCY和VIT D-T方面观察到两性之间的显著差异。年龄-性别相互作用对WBC、NEUT#、MCV、MCHC、PDW、GLB、ALP、Cre、CHOL、TRIG、HDL、LDL、HCY、IL-6、Vit B12、Vit D-T产生显著影响。然而，年龄、性别和年龄-性别相互作用对MO%、MOMO#、MCH、RDW-SD、CRP和CT均无显著影响。结论：本研究调查了恒河猴的血液参数，为恒河猴相关的科学实验研究提供了参考依据。

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.