Results of Routine Antenatal Screening for Cytomegalovirus at a Tertiary Center.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Medeniyet medical journal Pub Date : 2023-09-28 DOI:10.4274/MMJ.galenos.2023.84042

Duygu Tugrul Ersak, Izzet Ozgurluk, Ayse Gulcin Bastemur, Esra Gulen Yildiz, Selcan Sinaci, Ezgi Turgut, Ozgur Kara, Atakan Tanacan, Dilek Sahin

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Abstract

Objective: Cytomegalovirus (CMV) is the most common viral infection. In this study, we discussed the results of pregnant women who underwent antenatal CMV screening in a tertiary center and the value of CMV antenatal screening.

Methods: For this retrospective study, the data of pregnant patients with antenatal CMV screening test results between 2019 and 2022 were obtained from hospital records. CMV immunoglobulin M (IgM), CMV IgG, anti-IgG avidity test results, amniocentesis, CMV polymerase chain reaction (PCR), and the outcome of the babies were recorded.

Results: A total of 31,912 CMV IgM and 26,969 CMV IgG tests were performed. CMV IgG seropositivity was observed in 78.99% of pregnant women, and 0.09% of the pregnant women were confirmed to have a positive CMV IgM test result. Pregnant women with positive IgM accompanying low avidity were referred to perinatology clinics for detailed ultrasonography and amniocentesis. Only 3 of the 44 pregnant women who underwent amniocentesis were confirmed to have positive CMV PCR testing.

Conclusions: CMV screening should be preserved for pregnant women with ultrasonographic findings at high risk of congenital CMV infection.

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三级中心的巨细胞病毒产前常规筛查结果。

目的：巨细胞病毒（CMV）是最常见的病毒感染。在这项研究中，我们讨论了在三级中心接受产前CMV筛查的孕妇的结果以及CMV产前筛查的价值。方法：在这项回顾性研究中，从医院记录中获得2019年至2022年间产前CMV筛查结果的孕妇数据。记录CMV免疫球蛋白M（IgM）、CMV IgG、抗IgG亲和力测试结果、羊水穿刺、CMV聚合酶链式反应（PCR）和婴儿的结果。结果：共进行了31912次CMV IgM和26969次CMV IgG检测。在78.99%的孕妇中观察到CMV IgG血清阳性，0.09%的孕妇被证实CMV IgM检测结果呈阳性。IgM阳性并伴有低亲合力的孕妇被转诊到围产期诊所进行详细的超声检查和羊水穿刺。在接受羊水穿刺的44名孕妇中，只有3人被证实CMV PCR检测呈阳性。结论：对于超声检查结果为先天性巨细胞病毒感染高危的孕妇，应保留巨细胞病毒筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medeniyet medical journal Medicine-Medicine (all)

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.