Role of PPARG in Chemosensitivity-Regulating Network for Hypopharyngeal Squamous Cell Carcinoma.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL PPAR Research Pub Date : 2023-09-25 eCollection Date: 2023-01-01 DOI:10.1155/2023/6019318
Fanyong Kong, Boxuan Han, Jiaming Chen, Xixi Shen, Lizhen Hou, Jugao Fang, Meng Lian
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Abstract

PPARG has been reported to promote chemosensitivity in hypopharyngeal squamous cell carcinoma (HSCC). However, few studies tested its significance in the texture of a complex molecular network regulating chemosensitivity in HSCC. Here, we first employed RNA expression data analysis and literature data mining to uncover candidate genes related to HSCC chemosensitivity. Then, we constructed the molecular network regulating chemosensitivity in HSCC. After that, we employed degree centrality (DC) and weighted centrality (WC) to test the significance of PPARG within the regulating network. Pathway enrichment was done to study the cofunctions of PPARG and the rest of the genes within the network. The findings of our study contribute to the construction of a comprehensive network that regulates HSCC chemosensitivity, consisting of 57 genes, including PPARG. Notably, within this network, PPARG demonstrates a ranking of #5 and #13 based on DC and WC, respectively. Moreover, PPARG is connected to 29 out of the 57 genes and plays roles in multiple functional groups. These top related genes include AKT1, TP53, PTEN, MAPK1, NOTCH1, BECN1, PTGS2, SPP1, and RAC1. PPARG gets enriched in several key functional groups that have been implicated in the regulation of chemosensitivity, including those associated with the response to nutrients, vitamins, and peptides, the cellular response to chemical stress, and the regulation of hormone secretion and growth. Our results emphasize the involvement of PPARG and its interconnectedness with other genes in the regulation of HSCC chemosensitivity.

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PPARG在下咽鳞状细胞癌化疗敏感性调节网络中的作用。
PPARG已被报道可促进下咽鳞状细胞癌(HSCC)的化疗敏感性。然而,很少有研究测试其在调节HSCC化学敏感性的复杂分子网络结构中的意义。在这里,我们首先采用RNA表达数据分析和文献数据挖掘来揭示与HSCC化疗敏感性相关的候选基因。然后,我们构建了调节HSCC化疗敏感性的分子网络。之后,我们使用度中心性(DC)和加权中心性(WC)来测试PPARG在调节网络中的显著性。通路富集是为了研究PPARG和网络中其他基因的共同功能。我们的研究结果有助于构建一个由57个基因组成的调节HSCC化学敏感性的综合网络,包括PPARG。值得注意的是,在该网络中,PPARG分别基于DC和WC显示了#5和#13的排名。此外,PPARG与57个基因中的29个相连,并在多个官能团中发挥作用。这些顶级相关基因包括AKT1、TP53、PTEN、MAPK1、NOTCH1、BECN1、PTGS2、SPP1和RAC1。PPARG富含与化学敏感性调节有关的几个关键官能团,包括与对营养素、维生素和肽的反应、细胞对化学应激的反应以及激素分泌和生长的调节有关的官能团。我们的研究结果强调PPARG及其与其他基因在HSCC化疗敏感性调节中的相互作用。
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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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