New protocol in the treatment of Peyronie's disease by combining platelet-rich plasma, percutaneous needle tunneling, and penile modeling: Preliminary results.

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY Progres En Urologie Pub Date : 2024-01-01 Epub Date: 2023-09-28 DOI:10.1016/j.purol.2023.09.013

M Alshuaibi, A S Zugail, S Lombion, S Beley

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Abstract

Introduction: Intra-lesional injections of collagenase (Xiapex®) were the only non-invasive treatment option for Peyronie's disease (PD), until their withdrawal from the European market.

Objective: To evaluate the feasibility, efficacy, and safety of a combined treatment of percutaneous needle tunnelling (PNT) with penile modelling (PM) and the injection of platelet-rich plasma (PRP) under general anesthesia in the treatment of PD.

Patients and method: A prospective case series study included patients with PD in a stable phase who underwent this procedure between March 2020 and January 2023. The main outcome was an improvement in curvature.

Result: Thirty-six patients underwent this novel approach for the treatment of PD. The pretreatment mean±standard deviation (SD) curvature degree was 57.5±20.61° (range 20-90°). After the protocol, the mean curvature degree was 40.86±25.13° (range 0-90°). The curvature angle improved significantly (P=0.0001), with a mean improvement difference of 16.85±14.81° (range 0-50°) and a mean improvement percentage of 47.7±40.29% (range 0-100%).

Conclusion: Our preliminary experience suggests that PNT and PRP injections with PM are effective and safe for the treatment of penile deformity of PD.

Level of evidence: 4: case series study.

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结合富含血小板的血浆、经皮穿刺和阴茎模型治疗佩罗尼病的新方案：初步结果。

引言：病灶内注射胶原酶（Xiapex®）是佩罗尼病（PD）的唯一非侵入性治疗选择，直到它们退出欧洲市场。目的：评价其临床应用的可行性、有效性和安全性，以及在全身麻醉下，经皮穿刺穿刺（PNT）与阴茎模型（PM）和注射富含血小板血浆（PRP）联合治疗帕金森病的安全性。患者和方法：一项前瞻性病例系列研究包括2020年3月至2023年1月期间接受该手术的稳定期帕金森病患者。主要结果是曲率有所改善。结果：36例患者采用这种新方法治疗PD，治疗前平均值±标准差（SD）曲度为57.5±20.61°（范围20-90°）。方案完成后，平均弯曲度为40.86±25.13°（范围0-90°）。曲率角明显改善（P=0.0001），平均改善差异为16.85±14.81°（范围0-50°），平均改进率为47.7±40.29%（范围0-100%）。结论：我们的初步经验表明，PNT和PRP注射PM治疗PD阴茎畸形是有效和安全的。证据水平：4：病例系列研究。

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来源期刊

Progres En Urologie 医学-泌尿学与肾脏学

CiteScore

1.80

自引率

27.30%

发文量

132

审稿时长

54 days

期刊介绍： Une publication rapide des travaux en urologie: retrouvez les derniers travaux de recherche, études et enquêtes, en Urologie, publiés sous la forme de revues, mises au point, articles originaux, notes techniques, cas cliniques pertinents et originaux, lettres à la rédaction, revues de la littérature, textes de recommandation,... La revue publie également des articles pour les infirmières en Urologie. Une approche pluridisciplinaire : Progrès en Urologie aborde toutes les pathologies urologiques. Aux 13 numéros de Progrès viennent s''ajouter 4 numéros de Progrès en Urologie Pelvi-Périnéologie