Treatment of multiple system atrophy - the past, present and future.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2018-10-05
Haiyan Yu, Xiaoling Yuan, Lifeng Liu, Tian Wang, Dianrong Gong
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Abstract

Multiple system atrophy is a sporadic progressive degenerative disease which is characterized by multiple central nervous systems involved. So far, there is no effective medicine to cure MSA. The main research direction of treatment includes immunization transplantation and cytotherapy. Human umbilical cord blood is the residue of blood in the placenta and umbilical cord after fetal delivery. It is the most abundant cell bank and its usage is not limited to treat hematological diseases. The researches about hUCB-MNC treatment on MSA are increasing gradually. The potential of other MSC is also discussed. Lateral atlanto-occipital space puncture is an ingenious way created by Professor Dianrong Gong. More than 30 cases of MSA have been treated by this method with fine clinical effect and without serious complications. It indicates that stem cells treatment is a valid method for refractory nerve system diseases.

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多系统萎缩的治疗——过去、现在和未来。
多系统萎缩是一种散发性进行性退行性疾病,其特征是涉及多个中枢神经系统。到目前为止,还没有有效的药物来治疗MSA。治疗的主要研究方向包括免疫移植和细胞治疗。人类脐带血是胎儿分娩后胎盘和脐带中的血液残留物。它是最丰富的细胞库,其用途不仅限于治疗血液病。关于hUCB-MNC治疗MSA的研究逐渐增多。还讨论了其他MSC的潜力。寰枕外侧间隙穿刺是龚殿荣教授独创的一种方法。该方法治疗MSA 30余例,临床效果良好,无严重并发症。这表明干细胞治疗是治疗难治性神经系统疾病的有效方法。
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