HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis.

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY Applied Immunohistochemistry & Molecular Morphology Pub Date : 2023-11-01 Epub Date: 2023-09-26 DOI:10.1097/PAI.0000000000001160

Lin Xu, Guohua Yu, Lei Jiang, Xiao Song, Guimei Qu, Jie Luo, Li Cai

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引用次数: 0

Abstract

Objective: To investigate the expression and clinical significance of HepPar1 and GATA-3 in neuroendocrine neoplasms (NENs).

Materials and methods: The expression of HepPar1 and GATA-3 in 144 cases of NENs was detected using immunohistochemistry, and the relevant literature was reviewed.

Results: HepPar1 was localized in the cytoplasm, and the positive rate of HepPar1 was 6.25% (9/144) in 144 NENs, 9 of which were derived from gastrointestinal and pancreatic NENs, including 4 cases of neuroendocrine tumor, grade 1 (NET G1), 4 cases of NET G2, and 1 case of NET G3. GATA-3 was localized in the nucleus; the positive rate of GATA-3 was 7.62% (11/144), which was derived from 5 cases of gastrointestinal and pancreatic NENs, 2 cases of the lung, 2 cases of the liver, 1 case of the testis, and 1 case of the mediastinum. HepPar1 and GATA-3 were coexpressed in 4 cases: 2 cases of gastric NET G1, 1 case of gastric NET G2, and 1 case of pancreatic NET G3 with liver metastasis.

Conclusions: HepPar1 and GATA-3 can be expressed in NENs, which are potential traps for the pathologic and differential diagnosis of tumors.

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HepPar1和GATA-3在神经内分泌肿瘤中的表达：病理诊断的潜在陷阱。

目的：探讨HepPar1和GATA-3在神经内分泌肿瘤中的表达及其临床意义。结果：HepPar1定位于细胞质，在144个神经内分泌肿瘤中，HepPar 1的阳性率为6.25%（9/144），其中9个来源于胃肠道和胰腺神经内分泌肿瘤，其中4例为神经内分泌肿瘤1级（NET G1），4例为NET G2，1例为NET G3。GATA-3定位于细胞核；GATA-3的阳性率为7.62%（11/144），其来源于5例胃肠道和胰腺NEN、2例肺、2例肝、1例睾丸和1例纵隔。HepPar1和GATA-3在4例中共表达：2例胃NET G1，1例胃NET G2，1例胰腺NET G3伴肝转移。结论：HepPar1和GATA-3可在NENs中表达，是肿瘤病理和鉴别诊断的潜在陷阱。

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.