Adenosine A2A receptor and glia.

International review of neurobiology Pub Date : 2023-01-01 Epub Date: 2023-09-07 DOI:10.1016/bs.irn.2023.08.002
Zhihua Gao
{"title":"Adenosine A<sub>2A</sub> receptor and glia.","authors":"Zhihua Gao","doi":"10.1016/bs.irn.2023.08.002","DOIUrl":null,"url":null,"abstract":"<p><p>The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) is abundantly expressed in the brain, including both neurons and glial cells. While the expression of A<sub>2A</sub>R is relative low in glia, its levels elevate robustly in astrocytes and microglia under pathological conditions. Elevated A<sub>2A</sub>R appears to play a detrimental role in a number of disease states, by promoting neuroinflammation and astrocytic reaction to contribute to the progression of neurodegenerative and psychiatric diseases.</p>","PeriodicalId":94058,"journal":{"name":"International review of neurobiology","volume":"170 ","pages":"29-48"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of neurobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.irn.2023.08.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

The adenosine A2A receptor (A2AR) is abundantly expressed in the brain, including both neurons and glial cells. While the expression of A2AR is relative low in glia, its levels elevate robustly in astrocytes and microglia under pathological conditions. Elevated A2AR appears to play a detrimental role in a number of disease states, by promoting neuroinflammation and astrocytic reaction to contribute to the progression of neurodegenerative and psychiatric diseases.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
腺苷A2A受体与胶质细胞。
腺苷A2A受体(A2AR)在大脑中大量表达,包括神经元和神经胶质细胞。虽然A2AR在神经胶质中的表达相对较低,但在病理条件下,其在星形胶质细胞和小胶质细胞中的水平显著升高。A2AR升高似乎在许多疾病状态中发挥着有害作用,通过促进神经炎症和星形细胞反应,导致神经退行性疾病和精神疾病的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
A general clinical overview of the non-motor symptoms in Parkinson's disease: Neuropsychiatric symptoms. Executive dysfunction and cognitive decline, a non-motor symptom of Parkinson's disease captured in animal models. Insight gained from using animal models to study pain in Parkinson's disease. Investigating affective neuropsychiatric symptoms in rodent models of Parkinson's disease. Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson's disease.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1