Clinical evaluation of the combined efficacy of injectable platelet-rich fibrin along with scaling and root planing in the non-surgical periodontal therapy of stage III and grade C periodontitis patients having type 2 diabetes mellitus: A randomized controlled trial

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Advances in Periodontics Pub Date : 2023-09-25 DOI:10.1002/cap.10266

Prasanth D Shunmuga, Anupama Tadepalli, Harinath Parthasarathy, Deepa Ponnaiyan, Priyanka k Cholan, Lakshmi Ramachandran

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Abstract

Background

This randomized controlled trial was aimed to evaluate the combined efficacy of injectable platelet-rich fibrin (i-PRF) and scaling and root planing (SRP) in type 2 diabetes mellitus subjects having periodontitis.

Methods

Twenty-six Stage III, grade C periodontitis subjects (HbA1c > 7) were recruited in this split-mouth study. Following SRP, the test sites received subgingival application of i-PRF, while the control sites received saline. Plaque index, bleeding on probing, modified gingival index, probing pocket depth (PPD) and clinical attachment level (CAL) were measured at baseline, 3 and 6 months.

Results

Twenty-three participants completed the course of research. The Friedman test followed by Dunn's post hoc test, revealed significant improvement in all the clinical parameters from baseline to 3 and 6 months in both the study groups (p ≤ 0.05). The mean PPD and CAL decreased from 6.30 ± 1.25 and 7.48 ± 1.75 at baseline to 3.48 ± 1.34 and 4.39 ± 1.67 at 6 months in control sites and from 6.57 ± 1.56 and 7.61 ± 1.69 to 3.39 ± 1.23 and 4.26 ± 1.81 at 6 months in test sites (p ≤ 0.0001). Intergroup analysis found no statistical significant differences in the evaluated parameters across all time intervals (p > 0.05)

Conclusion

The results indicated that the adjunctive application of i-PRF to SRP provided similar benefits as saline and SRP in diabetes mellitus subjects.

Key points

Question: To find the combined efficacy of injectable platelet-rich fibrin (i-PRF) along with scaling and root planing (SRP) in the management of periodontal pockets of Stage III and Grade C periodontitis patients having Type 2 Diabetes Mellitus (T2DM).
Finding: All of the treated sites showed satisfactory healing. Both the treatment modalities (i-PRF + SRP and Saline + SRP) were effective in the treatment of periodontal pockets. At 3 and 6 months, there were no significant differences in periodontal parameters between groups.
Meaning: The application of i-PRF as an adjunct to SRP provided similar benefits as saline and SRP in improving clinical parameters in subjects with stage III and grade C periodontitis patients having T2DM (HbA1C > 7).

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注射用富含血小板的纤维蛋白与洁治和根刨在2型糖尿病III期和C级牙周炎患者非手术牙周治疗中的联合疗效的临床评估：一项随机对照试验。

背景：这项随机对照试验旨在评估注射用富含血小板的纤维蛋白（i-PRF）和洁治和牙根刨削（SRP）对患有牙周炎的2型糖尿病受试者的联合疗效。方法：在这项分口研究中招募了26名III期C级牙周炎受试者（HbA1c>7）。SRP后，试验部位接受龈下i-PRF应用，而对照部位接受生理盐水。在基线、3个月和6个月时测量牙菌斑指数、探查出血量、改良牙龈指数、探查袋深度（PPD）和临床附着水平（CAL）。结果：23名参与者完成了研究课程。Friedman检验之后是Dunn的post-hoc检验，结果显示，从基线到3个月和6个月，两个研究组的所有临床参数都有显著改善（p≤0.05）。对照组的平均PPD和CAL从基线时的6.30±1.25和7.48±1.75降至6个月时的3.48±1.34和4.39±1.67，试验组从6.57±1.56和7.61±1.69降至3.39±1.23和4.26±1.81（p≤0.0001）。组间分析发现，在所有时间间隔内，评估参数没有统计学上的显著差异（p>0.05）结论：结果表明，i-PRF对SRP的辅助应用在糖尿病受试者中提供了与生理盐水和SRP相似的益处。要点：问题：寻找注射富含血小板的纤维蛋白（i-PRF）与刮治和根刨（SRP）在治疗患有2型糖尿病（T2DM）的III期和C级牙周炎患者的牙周袋中的联合疗效。发现：所有治疗部位都显示出满意的愈合。两种治疗方式（i-PRF+SRP和Saline+SRP）均能有效治疗牙周袋。在3个月和6个月时，两组之间的牙周参数没有显著差异。意义：在患有T2DM（HbA1C>7）的III期和C级牙周炎患者中，应用i-PRF作为SRP的辅助药物在改善临床参数方面提供了与生理盐水和SRP类似的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Advances in Periodontics DENTISTRY, ORAL SURGERY & MEDICINE-

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1.60

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