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Root coverage of type 2/3 gingival recession using recombinant human fibroblast growth factor-2 in combination with carbonate apatite granules: A case study. 重组人成纤维细胞生长因子-2与碳酸盐磷灰石颗粒联合治疗2/3型牙龈萎缩的根覆盖研究
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-02 DOI: 10.1002/cap.70031
Akiyoshi Funato, Akihiko Katayama, Chihiro Ishikura, Yusuke Katsuda, Akira Hasuike

Background: One of the most challenging aspects of the treatment of Cairo Recession Type (RT) 2/3 gingival recession is the loss of adjacent interdental tissue. Successful treatment can be achieved by repositioning the interdental tissue and applying a connective tissue graft (CTG).

Methods and results: Two patients with RT2/3 gingival recession were treated using the vertical incision tunnel (VIT) technique. Recombinant human fibroblast growth factor-2 (rhFGF-2)-soaked carbonate apatite (CO3Ap) was placed in the interdental space, while rhFGF-2-soaked CTG was used to cover the exposed root surfaces. Over a follow-up period of up to 2 years, complete or significant root coverage was achieved in both cases. Interdental papillae were successfully reconstructed; however, complete papillary filling was not achieved.

Conclusions: The combination of rhFGF-2-soaked CO3Ap in the interdental space and rhFGF-2-soaked CTG for root coverage represents an effective approach for treating RT3 gingival recessions.

Plain language summary: Gum recession is a common dental condition where the gums pull away from the teeth, leaving the roots exposed. This can lead to tooth sensitivity, increased risk of decay, and esthetic concerns. Treating advanced forms-classified as Type 2 and Type 3-is especially difficult because not only are the roots exposed, but the gum tissue between the teeth is also lost. In this case report, two patients with these advanced types of gum recession were treated using a novel approach that combines regenerative materials with a minimally invasive surgical technique. A tissue-regenerating protein called rhFGF-2 was applied to both a synthetic bone substitute (CO3Ap) placed between the teeth and to soft tissue taken from the roof of the mouth. This tissue was used to cover the exposed roots. Over the course of follow-up, the treated areas healed well: most of the roots became re-covered with healthy gum tissue, and the tissue between the teeth, although not fully restored, showed clear signs of regeneration. While further studies are needed, this technique may provide a promising new option for patients with difficult-to-treat gum recession, especially in cases where traditional treatments have limited success due to loss of supporting structures.

背景:治疗Cairo衰退型(RT) 2/3牙龈衰退最具挑战性的方面之一是邻近牙间组织的损失。成功的治疗可以通过重新定位牙间组织和应用结缔组织移植物(CTG)。方法与结果:采用垂直切口隧道(VIT)技术治疗2例RT2/3龈退缩。将重组人成纤维细胞生长因子-2 (rhFGF-2)浸泡的碳酸盐磷灰石(CO3Ap)放置在牙间隙中,用rhFGF-2浸泡的CTG覆盖暴露的根表面。在长达2年的随访期间,两例患者均实现了完全或显著的根覆盖。成功重建牙间乳头;然而,没有实现完全的乳头填充。结论:结合rhfgf -2浸泡的CO3Ap和rhfgf -2浸泡的CTG进行牙根覆盖是治疗RT3牙龈衰退的有效方法。简单的语言总结:牙龈萎缩是一种常见的牙齿疾病,牙龈从牙齿上脱落,使牙根暴露在外。这可能会导致牙齿敏感,增加蛀牙的风险,以及美观问题。治疗高级形式的牙病(分为2型和3型)尤其困难,因为不仅牙根暴露在外,而且牙齿之间的牙龈组织也会消失。在这个病例报告中,两名患有这些高级牙龈退缩的患者使用了一种结合再生材料和微创手术技术的新方法进行治疗。一种叫做rhFGF-2的组织再生蛋白被应用于放置在牙齿之间的合成骨替代物(CO3Ap)和从口腔上颚取下的软组织。这种组织被用来覆盖暴露的根。在随访过程中,治疗区域愈合良好:大部分牙根重新被健康的牙龈组织覆盖,牙齿之间的组织虽然没有完全恢复,但显示出明显的再生迹象。虽然需要进一步的研究,但这项技术可能为难以治疗的牙龈退缩患者提供了一个有希望的新选择,特别是在传统治疗因失去支撑结构而成功有限的情况下。
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引用次数: 0
Periodontal microsurgery: Historical development and integration into periodontics. 牙周显微外科:牙周病的历史发展和整合。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-26 DOI: 10.1002/cap.70040
Leonard S Tibbetts

Periodontal microsurgery is a refined enhancement of the various types of periodontal and implant surgery using a binocular surgical microscope, with techniques, instruments and sutures borrowed from medicine. A continuing education program on periodontal microsurgery was first presented to the American Academy of Periodontology Annual Meeting in Orlando in 1992. It has taken over 30 years to gain the attention of the Academy membership due to the additional specialized training, equipment and practice necessary to become and remain proficient in microsurgical techniques. True periodontal microsurgery exceeds surgery using surgical loupes. An operating surgical microscope offers varying magnifications from two and a half to 25 times normal vision. This enhances the surgeon's ability to perform more accurate, smaller initial butt joint incisions, achieve uniform flap thickness, remove all tissue tags, perform the various types of periodontal and implant surgery, and precisely reposition the postsurgical tissues for primary closure. Proficient periodontal microsurgical treatment results in less patient discomfort, faster healing, more predictable treatment results, and better patient acceptance. KEY POINTS: The incorporation of microscopic magnification into periodontal practices, with the necessary and appropriate training and practice, results in improved visual acuity, ergonomic benefits, increased precision in flap design, surgical detailing, and suture closure. The increased precision results in faster and improved healing results and enhanced patient acceptance.

牙周显微外科是对各种类型的牙周和种植手术的改进,使用双目外科显微镜,技术,仪器和缝合线借鉴医学。1992年,在奥兰多举行的美国牙周病学会年会上首次提出了牙周显微外科的继续教育计划。由于额外的专业培训、设备和实践需要成为并保持精通显微外科技术,它已经花了30多年的时间来获得学院成员的关注。真正的牙周显微手术超过了使用手术镜的手术。手术显微镜提供不同的放大倍数,从2.5到25倍的正常视力。这提高了外科医生进行更精确、更小的初始对接切口的能力,达到均匀的皮瓣厚度,去除所有组织标签,进行各种类型的牙周和种植手术,并精确地重新定位术后组织进行初级闭合。熟练的牙周显微外科治疗可以减少患者的不适,更快的愈合,更可预测的治疗结果,以及更好的患者接受。重点:将显微放大技术纳入牙周治疗,配合必要和适当的训练和实践,可提高视力,符合人体工程学,增加皮瓣设计的精度,手术细节和缝合闭合。精确度的提高导致更快和更好的愈合结果,并提高了患者的接受度。
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引用次数: 0
Vertex technique: A novel microsurgical technique for papilla reconstruction-Case study. 顶点技术:一种新的乳头重建显微外科技术-个案研究。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-26 DOI: 10.1002/cap.70028
Fernando Solanes, Juan Carlos Durán, Carolina Alarcón, María Dolores de la Jara, Valeria Gómez, Cristian Aguilera
<p><strong>Background: </strong>Interdental papilla is key to gingival health and esthetics. Its loss leads to black triangles, which affects the smile's appearance and increases periodontal risks. Various treatments have been proposed, but papilla reconstruction remains challenging due to anatomical and vascular limitations. This case report aims to describe the vertex technique (VT), a novel approach combining tunneling with connective tissue and bone grafts for papilla reconstruction.</p><p><strong>Methods: </strong>VT was performed on patients with papilla presence index (PPI) 3 and 4 defects and a thick gingival phenotype in the esthetic zone. A microsurgical approach was employed to create an interproximal tunnel, thereby minimizing tissue trauma and preserving the vascular supply. Custom-shaped connective tissue grafts were inserted to enhance soft tissue volume, while bone grafts targeted interproximal bone loss for additional support. The procedure emphasized careful flap management to optimize healing and graft stability. All patients were periodontally treated prior to surgery and were healthy at the time of the procedure.</p><p><strong>Results: </strong>VT achieved significant papilla augmentation, reducing the visibility of the black triangles, and improving gingival esthetics, from PPI 3 or 4 to PPI 2 after treatment. The integration of connective tissue and bone grafts resulted in enhanced soft tissue volume and long-term stability observed over follow-up periods of 1‒5 years.</p><p><strong>Conclusion: </strong>The VT offers a promising solution for interdental papilla defects PPI 3‒4, addressing both soft tissue and bone deficiencies. Its combination of microsurgical tunneling with grafting provides esthetic and stable results, expanding treatment options in periodontal plastic microsurgery.</p><p><strong>Key points: </strong>Vertex technique (VT) combines microsurgical tunneling with connective tissue and bone grafts to reconstruct interdental papillae with high precision and minimal trauma. Significant esthetic improvement and stable papilla height were achieved in papilla presence index 3‒4 defects, with outcomes maintained over 1‒5 years. VT is indicated for healthy, periodontally treated patients with thick phenotypes, although it requires advanced skills and resources for proper execution.</p><p><strong>Plain language summary: </strong>This study introduces the vertex technique, a new method to fix gaps (black triangles) between teeth caused by the loss of the interdental papilla. These gaps not only affect the look of a smile but can also harm gums' health. The technique uses a microsurgical approach to insert connective tissue and bone grafts, improving both soft tissue volume and bone support. It was used on patients with severe defects in the esthetic zone. Results showed a significant improvement in appearance and long-term stability, with no complications. The vertex technique offers a promising solution for these peri
背景:牙间乳头是牙龈健康和美观的关键。它的缺失会导致黑色三角形,影响微笑的外观,增加牙周疾病的风险。目前已经提出了多种治疗方法,但由于解剖学和血管的限制,乳头重建仍然具有挑战性。本病例报告旨在描述顶点技术(VT),一种结合隧道与结缔组织和骨移植的新方法,用于乳头重建。方法:对美观区乳头存在指数(PPI)为3、4级缺损、牙龈表型较厚的患者行VT。显微外科入路用于建立近端间隧道,从而最大限度地减少组织损伤并保持血管供应。植入定制形状的结缔组织移植物以增加软组织体积,而骨移植物针对近端间骨丢失提供额外支持。手术强调谨慎的皮瓣管理,以优化愈合和移植物的稳定性。所有患者在手术前都接受了牙周治疗,并且在手术时都很健康。结果:VT显著增强了乳头,减少了黑色三角形的可见性,改善了牙龈美观,治疗后PPI从3或4提高到PPI 2。结缔组织和骨移植物的整合增加了软组织体积和长期稳定性,随访1-5年。结论:VT是治疗牙间乳头缺陷PPI - 4的一种很有前途的方法,可同时解决软组织和骨缺陷。它结合了显微手术隧道与移植提供美观和稳定的结果,扩大了牙周整形显微手术的治疗选择。重点:顶点技术(VT)结合显微外科隧道与结缔组织和骨移植重建牙间乳头,精度高,创伤小。在乳头存在指数为3-4的缺陷中,获得了显著的美观改善和稳定的乳头高度,结果维持了1-5年。VT适用于健康的、接受过牙周治疗的厚表型患者,尽管它需要先进的技能和资源才能正确执行。摘要:本研究介绍了一种修复因牙间乳头缺失而造成的牙间间隙(黑色三角形)的新方法——顶点技术。这些间隙不仅会影响笑容的外观,还会损害牙龈的健康。该技术使用显微外科方法插入结缔组织和骨移植物,提高软组织体积和骨支撑。用于有严重审美区缺损的患者。结果显示外观和长期稳定性显著改善,无并发症。顶点技术为这些牙周问题提供了一个有希望的解决方案。
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引用次数: 0
Innovations in microsurgery: The role of non-invasive blood perfusion imaging-A review and framework. 显微外科的创新:无创血液灌注成像的作用——综述与框架。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-26 DOI: 10.1002/cap.70042
Amanda B Rodriguez, Oliver D Kripfgans, Diego Velasquez, Hsun-Liang Chan
<p><strong>Background: </strong>This review evaluates current literature on non-invasive blood perfusion imaging in periodontology, with a focus on applications in periodontal microsurgery.</p><p><strong>Methods: </strong>A hypothesis-building review was conducted by two reviewers from January 2022 to April 2025 across multiple databases.</p><p><strong>Results: </strong>Laser speckle contrast imaging (LSCI) and ultrasound (US) emerged as the most promising modalities. LSCI measures superficial gingival perfusion with high spatial resolution, demonstrating sensitivity to vascular dynamics and sex-related differences during tissue compression. US, using B-mode and color flow-based imaging, provides both anatomical and functional assessment of gingival and peri-implant tissues, showing correlations with inflammation and healing outcomes. Both techniques have been validated in clinical and preclinical settings as reliable tools for assessing perfusion during regenerative procedures. A clinical case illustrates the use of LSCI and US to evaluate blood perfusion in a grafted alveolar ridge.</p><p><strong>Conclusions: </strong>Blood perfusion is a key factor in wound healing, heavily influenced by surgical trauma and flap tension. Microsurgical techniques may improve outcomes by minimizing soft tissue trauma and preserving vascular integrity during flap procedures. LSCI and US together could offer complementary, real-time, chairside imaging to monitor perfusion, advancing personalized treatment strategies and improving prediction of healing outcomes in periodontal and peri-implant therapy.</p><p><strong>Key points: </strong>Laser speckle contrast imaging (LSCI) and ultrasound (US) emerge as the leading non-invasive modalities for assessing periodontal tissue perfusion, with LSCI capturing superficial microvascular flow and US providing complementary anatomical and functional detail. Evidence from recent clinical and preclinical studies, and an illustrative case example, demonstrates that both technologies reliably evaluate perfusion during regenerative and microsurgical procedures, including grafted alveolar ridges. Because adequate perfusion is essential for wound healing, integrating LSCI and US into periodontal practice may support real-time, personalized, data-driven clinical decision making and help optimize outcomes in periodontal and peri-implant therapy.</p><p><strong>Plain language summary: </strong>This review examines the use of non-invasive imaging technologies to assess blood flow (perfusion) in periodontal tissues, with a focus on their application in periodontal microsurgery. A literature search covering studies published from January 2022 to April 2025 identified laser speckle contrast imaging (LSCI) and ultrasound (US) as the most promising modalities. LSCI provides high-resolution assessment of superficial gingival perfusion and is sensitive to vascular changes, while US, using B-mode and color Doppler, offers both anatomical and funct
背景:本文综述了目前关于无创血液灌注成像在牙周病学中的应用,重点介绍了其在牙周显微外科中的应用。方法:从2022年1月至2025年4月,由两名审稿人对多个数据库进行假设构建综述。结果:激光散斑对比成像(LSCI)和超声成像(US)是最有前途的成像方式。LSCI测量浅表牙龈灌注具有高空间分辨率,在组织压缩过程中表现出对血管动力学和性别相关差异的敏感性。US使用b型和彩色血流成像,提供牙龈和种植体周围组织的解剖和功能评估,显示与炎症和愈合结果的相关性。这两种技术都已在临床和临床前环境中得到验证,作为评估再生过程中灌注的可靠工具。一个临床病例说明了使用LSCI和US来评估移植牙槽嵴的血液灌注。结论:血流灌注是创面愈合的关键因素,受手术创伤和皮瓣张力的影响较大。显微外科技术可以通过在皮瓣手术中减少软组织损伤和保持血管完整性来改善结果。LSCI和US一起可以提供互补的、实时的椅子旁成像来监测灌注,推进个性化治疗策略,并改善牙周和种植体周围治疗的愈合结果预测。激光散斑对比成像(LSCI)和超声(US)成为评估牙周组织灌注的主要非侵入性方式,LSCI捕获浅表微血管流动,而US提供互补的解剖和功能细节。来自最近临床和临床前研究的证据,以及一个说导性的案例表明,这两种技术都能可靠地评估再生和显微外科手术过程中的灌注,包括移植牙槽嵴。由于足够的灌注对伤口愈合至关重要,因此将LSCI和US整合到牙周实践中可能支持实时、个性化、数据驱动的临床决策制定,并有助于优化牙周和种植周治疗的结果。摘要:本文综述了非侵入性成像技术在牙周组织血流(灌注)评估中的应用,重点介绍了它们在牙周显微外科手术中的应用。一项涵盖2022年1月至2025年4月发表的研究的文献检索确定了激光散斑对比成像(LSCI)和超声(US)是最有前途的方式。LSCI提供了高分辨率的牙龈浅表灌注评估,对血管变化敏感,而US使用b超和彩色多普勒,提供了牙龈和种植体周围组织的解剖和功能洞察。正如文献综述所示,这两种技术在评估再生过程中的灌注方面都证明了临床和临床前的可靠性。作者提出的一个案例说明了LSCI和US如何结合使用来评估移植肺泡嵴的血流。充足的血流灌注对伤口愈合至关重要,但可能因手术创伤和皮瓣张力而受损。显微外科技术,旨在减少组织创伤和保持血管完整性,可以提高愈合效果。将LSCI和US整合到临床实践中可以实现实时的组织灌注评估,支持在牙周和种植周治疗中更加个性化、数据驱动的决策。
{"title":"Innovations in microsurgery: The role of non-invasive blood perfusion imaging-A review and framework.","authors":"Amanda B Rodriguez, Oliver D Kripfgans, Diego Velasquez, Hsun-Liang Chan","doi":"10.1002/cap.70042","DOIUrl":"https://doi.org/10.1002/cap.70042","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This review evaluates current literature on non-invasive blood perfusion imaging in periodontology, with a focus on applications in periodontal microsurgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A hypothesis-building review was conducted by two reviewers from January 2022 to April 2025 across multiple databases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Laser speckle contrast imaging (LSCI) and ultrasound (US) emerged as the most promising modalities. LSCI measures superficial gingival perfusion with high spatial resolution, demonstrating sensitivity to vascular dynamics and sex-related differences during tissue compression. US, using B-mode and color flow-based imaging, provides both anatomical and functional assessment of gingival and peri-implant tissues, showing correlations with inflammation and healing outcomes. Both techniques have been validated in clinical and preclinical settings as reliable tools for assessing perfusion during regenerative procedures. A clinical case illustrates the use of LSCI and US to evaluate blood perfusion in a grafted alveolar ridge.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Blood perfusion is a key factor in wound healing, heavily influenced by surgical trauma and flap tension. Microsurgical techniques may improve outcomes by minimizing soft tissue trauma and preserving vascular integrity during flap procedures. LSCI and US together could offer complementary, real-time, chairside imaging to monitor perfusion, advancing personalized treatment strategies and improving prediction of healing outcomes in periodontal and peri-implant therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;Laser speckle contrast imaging (LSCI) and ultrasound (US) emerge as the leading non-invasive modalities for assessing periodontal tissue perfusion, with LSCI capturing superficial microvascular flow and US providing complementary anatomical and functional detail. Evidence from recent clinical and preclinical studies, and an illustrative case example, demonstrates that both technologies reliably evaluate perfusion during regenerative and microsurgical procedures, including grafted alveolar ridges. Because adequate perfusion is essential for wound healing, integrating LSCI and US into periodontal practice may support real-time, personalized, data-driven clinical decision making and help optimize outcomes in periodontal and peri-implant therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;This review examines the use of non-invasive imaging technologies to assess blood flow (perfusion) in periodontal tissues, with a focus on their application in periodontal microsurgery. A literature search covering studies published from January 2022 to April 2025 identified laser speckle contrast imaging (LSCI) and ultrasound (US) as the most promising modalities. LSCI provides high-resolution assessment of superficial gingival perfusion and is sensitive to vascular changes, while US, using B-mode and color Doppler, offers both anatomical and funct","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proliferative verrucous leukoplakia: Case study of 24 years and outcome of treatment with CO2 laser. 增殖性疣状白斑:24 年的病例研究和二氧化碳激光治疗的结果。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-10-24 DOI: 10.1002/cap.10320
Charles M Cobb, Nabil E Beaini, Jessica Scully, Tanya M Gibson
<p><strong>Background: </strong>Proliferative verrucous leukoplakia (PVL) is a rare and refractory form of oral leukoplakia. The etiology of PVL remains unknown. The lesion is characterized by a high rate of malignant transformation. There is no definitive treatment for PVL.</p><p><strong>Methods: </strong>This case study presents a patient diagnosed in 2000 with a localized hyperkeratinized/verrucous lesion involving the facial gingivae of teeth #6-#8. Over the next 24 years, the lesion was biopsied five times. Further, two attempts to ablate the lesion with a CO<sub>2</sub> laser (10.6 µm wavelength) were performed. Both ablation treatments were unsuccessful as the lesion recurred and progressed to involve more areas of gingival tissue. To date, biopsy has not revealed transformation into verrucous or squamous cell carcinoma (SCCA).</p><p><strong>Results: </strong>This case study demonstrates that two attempts at ablation of PVL using a CO<sub>2</sub> laser had no short- or long-term benefit. The patient eventually lost all maxillary teeth due to root caries and inability to maintain adequate oral hygiene. The PVL lesion currently involves the entire maxillary edentulous ridge, extending from the 2nd molar site to the opposite corresponding site. During the 24 years encompassed by this report, the patient has not experienced a malignant transformation.</p><p><strong>Conclusion: </strong>The results of CO<sub>2</sub> laser ablation of the PVL lesion in this case provided no short- or long-term benefit. Given the potential for a sinister outcome, PVL patients require frequent clinical evaluation and biopsy for early detection of a malignant transformation into oral verrucous or SCCA.</p><p><strong>Key points: </strong>Proliferative verrucous leukoplakia (PVL) is a clinical diagnosis and represents a refractory form of multifocal oral mucosal leukoplakia of unknown origin. Currently, there is no reliable and successful treatment for PVL. PVL may undergo transformation to a verrucous or squamous cell carcinoma, thereby necessitating frequent oral examination and biopsy of sinister-appearing mucosal sites.</p><p><strong>Plain language summary: </strong>Proliferative verrucous leukoplakia (PVL) is a rare disorder that affects the gum tissue around the teeth. PVL is a pre-cancerous disorder for which the cause is unknown and there is no treatment that yields a consistently successful result. This case study presents a patient diagnosed in 2000 with PVL involving the facial gum tissue of the upper right cuspid, lateral, and central incisor teeth. Over the next 24 years, the lesion was biopsied five times and two attempts to irradicate the lesion with a CO<sub>2</sub> laser were performed. All attempts at treatment were unsuccessful and the lesion slowly progressed to involve more areas of gum tissue. The last biopsy taken in February 2024 did not reveal any areas of developing cancer. During the 24 years covered in this report, the patient did not deve
背景:增殖性疣状白斑病(PVL)是一种罕见的难治性口腔白斑病。PVL的病因至今不明。这种病变的特点是恶性转化率高。目前尚无治疗 PVL 的确切方法:本病例研究显示,患者于 2000 年被诊断为局部角化过度/疣状病变,病变累及 6-8 号牙齿的面部龈沟。在随后的 24 年中,该病变被活检了五次。此外,还两次尝试用二氧化碳激光(波长 10.6 µm)消融病变。这两次消融治疗都没有成功,因为病变复发了,并扩大到更多的牙龈组织区域。迄今为止,活检尚未发现疣状细胞癌或鳞状细胞癌(SCCA):本病例研究表明,使用 CO2 激光消融 PVL 的两次尝试均无短期或长期疗效。由于牙根龋齿和无法保持足够的口腔卫生,患者最终失去了所有上颌牙齿。目前,PVL 病变涉及整个上颌无牙颌嵴,从第二磨牙部位延伸到对侧相应部位。在本报告所述的 24 年间,患者未发生恶性转变:结论:本病例中 PVL 病变的 CO2 激光消融术没有带来短期或长期的益处。鉴于潜在的恶性结果,PVL 患者需要经常进行临床评估和活检,以便及早发现口腔疣状赘生物或 SCCA 的恶性转化:要点:增殖性疣状白斑(PVL)是一种临床诊断,是一种原因不明的难治性多灶性口腔黏膜白斑。目前,还没有可靠和成功的治疗方法来治疗 PVL。增生性疣状白斑(PVL)是一种影响牙齿周围牙龈组织的罕见疾病。增生性疣状白斑是一种癌前病变,病因不明,目前还没有一种治疗方法能取得持续成功的效果。本病例中的患者于 2000 年被诊断出患有 PVL,病变累及右上尖牙、侧切牙和中切牙的面部牙龈组织。在随后的 24 年中,该病灶被活检了五次,并两次尝试用二氧化碳激光照射病灶。所有的治疗尝试都没有成功,病变慢慢发展到累及更多的牙龈组织。最后一次活组织检查是在 2024 年 2 月,没有发现任何正在发展为癌症的区域。在本报告所述的 24 年中,该患者没有罹患口腔癌。然而,二氧化碳激光治疗并没有带来可衡量的益处。鉴于牙龈组织有可能罹患癌症,PVL 患者应经常接受口腔检查和定期活检,以发现早期癌症。
{"title":"Proliferative verrucous leukoplakia: Case study of 24 years and outcome of treatment with CO<sub>2</sub> laser.","authors":"Charles M Cobb, Nabil E Beaini, Jessica Scully, Tanya M Gibson","doi":"10.1002/cap.10320","DOIUrl":"10.1002/cap.10320","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Proliferative verrucous leukoplakia (PVL) is a rare and refractory form of oral leukoplakia. The etiology of PVL remains unknown. The lesion is characterized by a high rate of malignant transformation. There is no definitive treatment for PVL.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This case study presents a patient diagnosed in 2000 with a localized hyperkeratinized/verrucous lesion involving the facial gingivae of teeth #6-#8. Over the next 24 years, the lesion was biopsied five times. Further, two attempts to ablate the lesion with a CO&lt;sub&gt;2&lt;/sub&gt; laser (10.6 µm wavelength) were performed. Both ablation treatments were unsuccessful as the lesion recurred and progressed to involve more areas of gingival tissue. To date, biopsy has not revealed transformation into verrucous or squamous cell carcinoma (SCCA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This case study demonstrates that two attempts at ablation of PVL using a CO&lt;sub&gt;2&lt;/sub&gt; laser had no short- or long-term benefit. The patient eventually lost all maxillary teeth due to root caries and inability to maintain adequate oral hygiene. The PVL lesion currently involves the entire maxillary edentulous ridge, extending from the 2nd molar site to the opposite corresponding site. During the 24 years encompassed by this report, the patient has not experienced a malignant transformation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The results of CO&lt;sub&gt;2&lt;/sub&gt; laser ablation of the PVL lesion in this case provided no short- or long-term benefit. Given the potential for a sinister outcome, PVL patients require frequent clinical evaluation and biopsy for early detection of a malignant transformation into oral verrucous or SCCA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;Proliferative verrucous leukoplakia (PVL) is a clinical diagnosis and represents a refractory form of multifocal oral mucosal leukoplakia of unknown origin. Currently, there is no reliable and successful treatment for PVL. PVL may undergo transformation to a verrucous or squamous cell carcinoma, thereby necessitating frequent oral examination and biopsy of sinister-appearing mucosal sites.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Proliferative verrucous leukoplakia (PVL) is a rare disorder that affects the gum tissue around the teeth. PVL is a pre-cancerous disorder for which the cause is unknown and there is no treatment that yields a consistently successful result. This case study presents a patient diagnosed in 2000 with PVL involving the facial gum tissue of the upper right cuspid, lateral, and central incisor teeth. Over the next 24 years, the lesion was biopsied five times and two attempts to irradicate the lesion with a CO&lt;sub&gt;2&lt;/sub&gt; laser were performed. All attempts at treatment were unsuccessful and the lesion slowly progressed to involve more areas of gum tissue. The last biopsy taken in February 2024 did not reveal any areas of developing cancer. During the 24 years covered in this report, the patient did not deve","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":"329-336"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Root coverage using recombinant human fibroblast growth factor-2 treated connective tissue graft: Case studies. 使用重组人成纤维细胞生长因子-2处理结缔组织移植物的根覆盖:案例研究。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-12-02 DOI: 10.1002/cap.10323
Guo-Liang Cheng, Satoru Urano, Yu-Chang Wu, Rami Alsabbagh, Hsun-Liang Chan
<p><strong>Background: </strong>This case study documents the application of connective tissue graft (CTG) combined with biologics on treating challenging gingival recession cases of mandibular anterior teeth caused by orthodontic tooth movement.</p><p><strong>Methods: </strong>Three patients presented for periodontal consultation due to gingival recession resulting from orthodontic treatment. The patients reported esthetic concerns and discomfort while brushing their teeth. The gingival defects were mainly localized to the mandibular incisors, with recession depths ranging from 1 to 5 mm and complicated by loss of papilla and a lack of keratinized tissue. RT2 gingival recession with thin gingival phenotype was confirmed. All gingival defects were managed using recombinant human fibroblast growth factor-2 (rhFGF-2) treated CTG. The recipient sites were prepared using tunnel or modified tunnel techniques. CTG harvested from the hard palate was treated with rhFGF-2 for 3 min then inserted into the prepared tunnel space and secured with a sling suture technique for coronal advancement.</p><p><strong>Results: </strong>The three patients were followed from 6 months to 6 years. Generally, initial wound healing was within normal limits during the first several weeks. The recession defects were successfully covered, achieving a nearly 100% root coverage rate. The combination of CTG+rhFGF-2 resulted in satisfying recession depth reduction, papilla augmentation, and gain of keratinized tissue. Patients were satisfied with the improvement of esthetics and function.</p><p><strong>Conclusions: </strong>This innovative approach demonstrates that rhFGF-2 treated CTG significantly improves the mucogingival problems caused by orthodontic treatment. Successful phenotype modification provides functional and esthetic improvement as well as long-term stability of periodontal health.</p><p><strong>Plain language summary: </strong>Receding gums are a common complication after wearing dental braces, which sometimes can be severe if the initial gum tissue is thin. This complication could cause tooth sensitivity, discomfort when brushing, and compromised esthetics. To regenerate the lost tissue, a connective tissue graft (CTG) harvested from the roof of the oral cavity is very commonly used as a transplantation option with substantial supporting evidence. However, for cases of severe gum recession, CTGs still have limitations on treatment. Therefore, clinicians and researchers are dedicated to improving treatment outcomes by adding biomaterials to the graft to enhance clinical outcomes. A relatively new material, recombinant human fibroblast growth factor-2 (rhFGF-2), has proven to be effective in periodontal regenerative treatments and could potentially augment the soft tissue regenerative capacity of the graft. This case study documents the application of rhFGF-2 in combination with CTGs for treating severe gum recession in three patients. The treatment results demonstr
背景:本病例研究记录了结缔组织移植联合生物制剂治疗正畸牙齿移动引起的下颌前牙挑战性牙龈退缩病例。方法:对3例因正畸治疗导致牙龈萎缩的患者进行牙周会诊。患者报告了刷牙时的审美问题和不适。牙龈缺损主要局限于下颌切牙,退缩深度1 ~ 5mm,并伴有乳突缺失和角化组织缺失。证实RT2牙龈萎缩伴薄牙龈表型。所有牙龈缺损均采用重组人成纤维细胞生长因子-2 (rhFGF-2)处理CTG。采用隧道或改良隧道技术制备受体位点。硬腭CTG用rhFGF-2处理3分钟,然后插入准备好的隧道空间,用吊带缝合技术固定冠状推进。结果:3例患者随访6个月至6年。一般来说,最初的几周内伤口愈合在正常范围内。成功地覆盖了衰退缺陷,实现了接近100%的根覆盖率。CTG+rhFGF-2联合使用可使退缩深度减小,乳头增大,角质化组织增加。患者对美观和功能的改善感到满意。结论:该创新方法表明rhFGF-2治疗CTG可显著改善正畸治疗引起的粘膜牙龈问题。成功的表型修饰提供了功能和美观的改善以及牙周健康的长期稳定性。简单的语言总结:牙龈萎缩是戴牙套后常见的并发症,如果最初的牙龈组织很薄,有时会很严重。这种并发症会导致牙齿敏感,刷牙时不舒服,美观受损。为了再生失去的组织,从口腔顶部采集结缔组织移植物(CTG)是一种非常常用的移植选择,有大量的支持证据。然而,对于严重牙龈萎缩的病例,CTGs的治疗仍然有局限性。因此,临床医生和研究人员致力于通过在移植物中添加生物材料来改善治疗效果,以提高临床效果。重组人成纤维细胞生长因子-2 (rhFGF-2)是一种相对较新的材料,已被证明在牙周再生治疗中有效,并可能潜在地增强移植物的软组织再生能力。本案例研究记录了rhFGF-2联合CTGs治疗3例严重牙龈萎缩患者的应用。治疗结果显示显著改善,随访数据从6个月到6年不等。这些改进包括覆盖暴露的牙根表面,牙间组织的再生和牙龈组织的增厚。患者对这种方法在功能和美观方面产生的积极变化感到满意。
{"title":"Root coverage using recombinant human fibroblast growth factor-2 treated connective tissue graft: Case studies.","authors":"Guo-Liang Cheng, Satoru Urano, Yu-Chang Wu, Rami Alsabbagh, Hsun-Liang Chan","doi":"10.1002/cap.10323","DOIUrl":"10.1002/cap.10323","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This case study documents the application of connective tissue graft (CTG) combined with biologics on treating challenging gingival recession cases of mandibular anterior teeth caused by orthodontic tooth movement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Three patients presented for periodontal consultation due to gingival recession resulting from orthodontic treatment. The patients reported esthetic concerns and discomfort while brushing their teeth. The gingival defects were mainly localized to the mandibular incisors, with recession depths ranging from 1 to 5 mm and complicated by loss of papilla and a lack of keratinized tissue. RT2 gingival recession with thin gingival phenotype was confirmed. All gingival defects were managed using recombinant human fibroblast growth factor-2 (rhFGF-2) treated CTG. The recipient sites were prepared using tunnel or modified tunnel techniques. CTG harvested from the hard palate was treated with rhFGF-2 for 3 min then inserted into the prepared tunnel space and secured with a sling suture technique for coronal advancement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The three patients were followed from 6 months to 6 years. Generally, initial wound healing was within normal limits during the first several weeks. The recession defects were successfully covered, achieving a nearly 100% root coverage rate. The combination of CTG+rhFGF-2 resulted in satisfying recession depth reduction, papilla augmentation, and gain of keratinized tissue. Patients were satisfied with the improvement of esthetics and function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This innovative approach demonstrates that rhFGF-2 treated CTG significantly improves the mucogingival problems caused by orthodontic treatment. Successful phenotype modification provides functional and esthetic improvement as well as long-term stability of periodontal health.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Receding gums are a common complication after wearing dental braces, which sometimes can be severe if the initial gum tissue is thin. This complication could cause tooth sensitivity, discomfort when brushing, and compromised esthetics. To regenerate the lost tissue, a connective tissue graft (CTG) harvested from the roof of the oral cavity is very commonly used as a transplantation option with substantial supporting evidence. However, for cases of severe gum recession, CTGs still have limitations on treatment. Therefore, clinicians and researchers are dedicated to improving treatment outcomes by adding biomaterials to the graft to enhance clinical outcomes. A relatively new material, recombinant human fibroblast growth factor-2 (rhFGF-2), has proven to be effective in periodontal regenerative treatments and could potentially augment the soft tissue regenerative capacity of the graft. This case study documents the application of rhFGF-2 in combination with CTGs for treating severe gum recession in three patients. The treatment results demonstr","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":"354-363"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective treatment of a molar-incisor pattern periodontitis patient utilizing recombinant human platelet-derived growth factor: A case report. 重组人血小板源性生长因子有效治疗磨牙-切牙型牙周炎1例。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1002/cap.70022
Arsalan Danesh, Arman Danesh, Saynur Vardar, Theofilos Koutouzis

Background: Molar incisor pattern periodontitis (MIPP) poses many challenges in the field of periodontics. Emerging evidence has shown promising results in regenerative therapy while treating such a patient population. The present case study demonstrates an effective implementation of recombinant human platelet-derived growth factor (rh-PDGF) for the successful regeneration of infrabony defects associated with MIPP.

Methods: A 17-year-old African-American male patient presented to the Periodontics Clinic at Nova Southeastern University, requiring periodontal evaluation prior to the initiation of orthodontic therapy. Upon examination, the patient was diagnosed as a localized stage III, grade C MIPP. Initially, the patient underwent phase I therapy. Subsequently, surgeries consisted of regenerative procedures including a combination of allograft bone graft, rh-PDGF, and collagen membrane. The patient was seen for regular follow-ups and supportive periodontal therapy during the healing periods.

Results: The regenerative procedures resulted in significant improvement in all periodontal parameters, including probing depth, clinical attachment level, radiographic bone levels, and clinical and radiographic furcation closure, allowing the patient to retain all compromised teeth.

Conclusion: The combination of surgical debridement with rh-PDGF serves as a plausible treatment approach for infrabony defects in patients with MIPP. Further investigation through well-designed randomized controlled clinical trials is warranted to provide clearer insights.

Key point: rh-PDGF combined with an allograft is a successful treatment option in MIPP patients.

Plain language summary: Molar incisor pattern periodontitis (MIPP) is a severe form of periodontal disease, often affecting specific teeth in the periodontium of young patients. The nature of the disease requires early diagnosis and treatment to avoid potential complications, including tooth loss. This case report highlights the diagnosis and management of a patient with MIPP affecting seven teeth. Upon completion of the referral to the Periodontics Department at Nova Southeastern University, the patient was treatment planned for phase 1 therapy, including oral hygiene instructions, localized deep cleaning, and reevaluation of results in a short follow-up. Following the reevaluation appointment, the patient underwent a surgical phase via regenerative therapies utilizing bone grafts, biologics, and membranes. All surgical procedures resulted in significant improvements in clinical and radiographic parameters and remained stable over a 2-year follow-up period. This case report highlights the successful use of rh-PDGF in the treatment of MIPP-associated periodontal defects. Further investigation through well-designed clinical trials is warranted to provide clearer insights.

背景:磨牙牙型牙周炎(MIPP)在牙周病领域提出了许多挑战。新出现的证据表明,在治疗这类患者群体时,再生疗法取得了令人鼓舞的结果。本案例研究证明了重组人血小板衍生生长因子(rh-PDGF)在MIPP相关的下骨缺损成功再生中的有效应用。方法:一名17岁的非裔美国男性患者在诺瓦东南大学牙周病诊所就诊,要求在开始正畸治疗前进行牙周评估。经检查,患者被诊断为局限性III期,C级MIPP。最初,患者接受了I期治疗。随后,手术包括再生手术,包括异体骨移植、rh-PDGF和胶原膜的组合。患者在愈合期间接受定期随访和支持性牙周治疗。结果:再生手术显著改善了所有牙周参数,包括探探深度、临床附着水平、x线片骨水平、临床和x线片分叉闭合,使患者保留了所有受损的牙齿。结论:手术清创联合rh-PDGF是治疗MIPP患者骨下缺损的可行方法。通过精心设计的随机对照临床试验进行进一步调查,有必要提供更清晰的见解。重点:rh-PDGF联合同种异体移植物是MIPP患者成功的治疗选择。摘要:磨牙切牙型牙周炎(MIPP)是一种严重的牙周病,经常影响年轻患者牙周组织中的特定牙齿。这种疾病的性质需要早期诊断和治疗,以避免潜在的并发症,包括牙齿脱落。本病例报告强调了一个影响七颗牙齿的MIPP患者的诊断和处理。在完成转介到诺瓦东南大学牙周病科后,患者计划进行1期治疗,包括口腔卫生指导,局部深度清洁,并在短时间随访中重新评估结果。在重新评估预约之后,患者通过骨移植、生物制剂和膜的再生治疗进行了手术阶段。所有手术均显著改善了临床和影像学参数,并在2年随访期间保持稳定。本病例报告强调了rh-PDGF在治疗与mipp相关的牙周缺陷中的成功应用。通过精心设计的临床试验进行进一步的调查,有必要提供更清晰的见解。
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引用次数: 0
Management of peri-implant soft tissue dehiscence with combined prosthetic-surgical approach: A case report. 假体-外科联合入路治疗种植体周围软组织裂开1例。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1002/cap.70039
Omran Bishbish Zeino, Yoon Jeong Kim

Background: This case report presents the management of an esthetic complication of a peri-implant soft tissue dehiscence (PSTD) through a combined prosthetic-surgical approach.

Methods and results: A 53-year-old healthy Hispanic male presented to our practice for the treatment of an implant esthetic complication. A diagnosis of PSTD class III C was established. The abutment and crown were first modified to accommodate the tissue graft and support the coronally advanced flap (CAF). Then, a CAF with tuberosity connective tissue graft was performed. A definitive abutment and crown were fabricated 8 months after healing. Significant improvement of the PSTD, improvement of the peri-implant soft tissue dimensions, and patient satisfaction have been achieved.

Conclusion: A combined prosthetic-surgical approach constitutes a valid treatment modality for PSTD class III C where there is abundant interproximal tissue available.

Key points: Integrated treatment approach: A combined prosthetic-surgical technique offers an effective solution for managing peri-implant soft tissue dehiscence (PSTD), ensuring improved tissue thickness and stability.

Clinical considerations: The bucco-lingual implant position and interproximal tissue quality are key factors in determining the optimal treatment strategy. Predictable outcomes: Coronally advanced flap combined with connective tissue grafting can enhance esthetic and functional results for management of PSTD.

Plain language summary: Peri-implant soft tissue complications can affect both the function and appearance of dental implants. This case study explores an approach that combines surgical and prosthetic techniques to improve the gingival tissue surrounding an implant. A 53-year-old patient had an esthetic concern due to gum recession around his implant. To correct this, his dental crown and abutment were adjusted. Then, a gingival grafting procedure to reposition the gingival tissue and enhance its thickness was performed. After healing for eight months, the implant was permanently restored with a final crown. The results showed significant improvements in gingival tissue health, thickness, and appearance, leading to patient satisfaction. The findings highlight how combining surgical techniques with prosthetic adjustments can help manage similar cases, offering a predictable solution to improve both the appearance and stability of dental implants.

背景:本病例报告介绍了通过假体-外科联合入路治疗种植体周围软组织裂开(PSTD)的美学并发症。方法和结果:一名53岁的西班牙裔健康男性向我们介绍了种植体美学并发症的治疗。诊断为PSTD III C级。首先对基台和冠进行改良,以容纳组织移植物并支持冠状推进瓣(CAF)。然后行CAF合并结节结缔组织移植物。修复后8个月制作最终基台和冠。PSTD显著改善,种植体周围软组织尺寸改善,患者满意度提高。结论:对于近端间组织丰富的III级PSTD,假体-手术联合入路是一种有效的治疗方式。综合治疗方法:假体-外科联合技术为治疗种植体周围软组织开裂(PSTD)提供了有效的解决方案,确保了组织厚度和稳定性的提高。临床考虑:颊舌种植体位置和近端间组织质量是决定最佳治疗策略的关键因素。可预测的结果:冠状进展皮瓣联合结缔组织移植可以提高治疗PSTD的美观和功能效果。摘要:种植体周围软组织并发症会影响种植体的功能和外观。本案例研究探讨了一种结合手术和假体技术来改善种植体周围牙龈组织的方法。一名53岁的患者由于种植体周围的牙龈萎缩而担心美观。为了纠正这个问题,他调整了牙冠和基牙。然后,进行牙龈移植手术,以重新定位牙龈组织并增加其厚度。愈合8个月后,种植体被永久性地修复,并有一个最终的冠。结果显示牙龈组织健康、厚度和外观显著改善,患者满意。研究结果强调了如何将手术技术与假体调整相结合,可以帮助处理类似的病例,提供可预测的解决方案,以改善牙种植体的外观和稳定性。
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引用次数: 0
Odontogenic keratocyst management using guided tissue regeneration: Literature review - Two case reports. 引导组织再生治疗牙源性角化囊肿:文献回顾-两例报告。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1002/cap.10316
Bassam M Kinaia, Mirranda Kinaia, Joshua Graham, Naiomy Perez Villaneuva, David Van Winkle, Anmar Dawood, Anthony L Neely
<p><strong>Background: </strong>Odontogenic cysts of the jaws are pathologies that require timely recognition and management. The initial diagnosis is based on clinical and radiographic appearance and dental history. A variety of surgical treatments are used for odontogenic keratocyst (OKC) depending on the clinical and radiographic presentation. The aim of this report and literature review is to highlight methods to treat OKC combined with guided tissue regeneration (GTR).</p><p><strong>Methods: </strong>Two cases with similar clinical presentations are included. Case 1 was a 60-year-old healthy Caucasian female who presented with jaw expansion around teeth #'s 21 and 22. Initial exam revealed clinical gingival health on an intact periodontium. The patient presented with enlarged gingival tissue between teeth #'s 21 and 22 measuring 9 × 12 mm and vital teeth without root displacement radiographically. Case 2 had a similar clinical and radiographic presentation located between teeth #'s 5-6.</p><p><strong>Results: </strong>Case 1 treatment included excisional biopsy with complete enucleation of the cystic lesion. Thereafter, GTR was performed using allograft internally then covered with a xenograft externally, resorbable collagen membrane (RCM), and primary closure. Case 2 was managed with excisional biopsy with lesion enucleation, GTR with allogenic bone graft, enamel matrix derivative and RCM, and primary closure.</p><p><strong>Conclusion: </strong>OKC enucleation combined with GTR using mineralized allograft, enamel matrix derivative, and collagen membrane or a layering technique of allograft internally and xenograft externally covered by a collagen membrane showed proper regeneration with stable periodontium at 6-36 months.</p><p><strong>Key points: </strong>Guided tissue regeneration is an acceptable treatment for management of OKC. Complete enucleation of an OKC lesion is important to reduce recurrence. The use of allograft with xenograft or allograft with enamel matrix derivative and RCM can provide proper bone fill after OKC removal.</p><p><strong>Plain language summary: </strong>Odontogenic cysts are growths that can form in the jaw or soft tissues around the teeth. If not treated, they can grow larger, damage the bone, and even push teeth out of place. To prevent this, it's important to diagnose and remove them early. The most common way to treat these cysts is through a surgical method called enucleation, where the cyst is carefully removed. In these two cases, enucleation was used along with guided tissue regeneration, a technique to help the bone and tissue heal better after surgery. In the first case, a bone graft (made from human and animal bone) and a special material called a resorbable collagen membrane were used to protect and support the healing area. In the second case, a mineralized bone graft along with a substance that helps repair tissues called an enamel matrix derivative, and the same collagen membrane were used. Both p
背景:牙源性颌骨囊肿是一种需要及时识别和处理的疾病。最初的诊断是基于临床和放射学表现和牙齿病史。根据临床和影像学表现,牙源性角化囊肿(OKC)有多种手术治疗方法。本报告和文献综述的目的是强调治疗OKC结合引导组织再生(GTR)的方法。方法:回顾性分析2例临床表现相似的病例。病例1是一名60岁的健康白人女性,在第21和22颗牙齿周围出现颌骨扩张。初步检查显示牙龈健康,牙周组织完整。患者x线片显示21 ~ 22号牙间牙龈组织增大,尺寸为9 × 12 mm,重要牙无牙根移位。病例2有类似的临床和影像学表现,位于牙齿# 5-6之间。结果:病例1的治疗包括切除活检和囊性病变完全去核。之后,采用同种异体移植物进行GTR,外部覆盖异种移植物,可吸收胶原膜(RCM),并进行初级闭合。病例2采用病变去核切除活检、同种异体骨移植、牙釉质基质衍生物和RCM的GTR和初级闭合。结论:矿化同种异体移植物、牙釉质基质衍生物、胶原膜或同种异体移植物外覆盖胶原膜分层技术的OKC去核联合GTR在6-36个月时牙周组织稳定,再生良好。重点:引导组织再生是一种可接受的治疗OKC的管理。OKC病变的完全去核对减少复发很重要。同种异体移植与异种移植或同种异体移植与牙釉质基质衍生物和RCM可以提供适当的骨填充。牙源性囊肿是生长在颌骨或牙齿周围的软组织中。如果不及时治疗,它们会变大,损害骨骼,甚至使牙齿错位。为了预防这种情况,及早诊断和切除是很重要的。治疗这些囊肿最常见的方法是通过一种叫做去核的手术方法,在这种方法中,囊肿被小心地移除。在这两个病例中,去核术与引导组织再生一起使用,这是一种帮助骨和组织在手术后更好愈合的技术。在第一种情况下,骨移植物(由人骨和动物骨制成)和一种称为可吸收胶原蛋白膜的特殊材料被用来保护和支持愈合区域。在第二种情况下,使用矿化骨移植物以及一种有助于修复组织的物质,称为牙釉质基质衍生物,以及相同的胶原蛋白膜。两名患者都愈合得很好,在接下来的6到36个月里,他们的牙齿周围的骨骼和组织都正常地再生了。
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引用次数: 0
Management of peri-implantitis with a reconstructive approach: Guided bone regeneration using the open membrane technique - A case study. 种植体周围炎重建方法的处理:使用开放膜技术引导骨再生:一个案例研究。
IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-07-28 DOI: 10.1002/cap.70001
Hsin-Chiang Lee
<p><strong>Background: </strong>The restoration of the healthy peri-implant tissue and re-osseointegration represent the goals of reconstructive procedures for treating peri-implantitis. Peri-implant regeneration is a field that requires further optimization to increase predictability. The submerged approach has been shown to yield superior defect fill compared to the non-submerged approach. Nevertheless, primary closure in the submerged approach can result in diminished keratinized tissue. This case study presents an alternative approach to managing advanced peri-implantitis, with the use of open membrane technique.</p><p><strong>Methods: </strong>A 71-year-old female presented with #30 peri-implantitis, exhibiting 10 mm probing depth, suppuration upon probing, and severe bone loss. The implant prosthesis was removed prior to the surgery to gain access to instrumentation. Subsequent to the debridement of the defect and implant detoxification, a mix of xenograft and enamel matrix derivatives was used to fill the defect. High-density polytetrafluoroethylene membrane was placed over the defect. The flaps were replaced without attempting primary closure, and the membrane was intentionally left exposed.</p><p><strong>Results: </strong>Disease resolution with significant radiographic bone fill was achieved and remained stable with 20 months follow-up. In addition, keratinized tissue was adequately preserved after surgery.</p><p><strong>Conclusion: </strong>Reconstructive surgery using the open membrane approach can be an alternative for managing advanced peri-implantitis defects, with the advantages of preserving keratinized tissue and reducing intrasurgical trauma.</p><p><strong>Key points: </strong>The open membrane technique may serve as a viable alternative to primary closure in guided bone regeneration for peri-implant reconstructive procedures. Advantages include reduced surgical trauma, shorter procedure time, and preservation of keratinized tissue. Careful case selection is essential for achieving predictable outcomes. Factors to consider include defect configuration, the number of remaining bony walls, and the size of the wound opening. In more challenging cases, combination therapy and the adjunctive use of biologics may be considered to enhance regenerative potential and improve clinical results.</p><p><strong>Plain language summary: </strong>This case study presents the regenerative treatment of chronic inflammation and bone loss around a dental implant using the open membrane technique. To manage the condition, the crown portion of the dental implant was removed, and the implant surface was thoroughly cleaned and disinfected. The space around the implant was then filled with bone graft and biological agents and covered with a membrane. Unlike typical regenerative procedures, the membrane was intentionally left partially exposed rather than being fully covered by the gum during healing. After the procedure, the infection was resolved, and
背景:健康种植体周围组织的恢复和再骨整合是治疗种植体周围炎重建手术的目标。种植体周围再生是一个需要进一步优化以增加可预测性的领域。与非浸没入路相比,浸没入路已被证明能产生更好的缺陷填充。然而,浸没入路的初步闭合可导致角化组织减少。本病例研究提出了一种治疗晚期种植体周围炎的替代方法,即使用开膜技术。方法:一名71岁女性患者表现为#30种植体周围炎,表现为探探深度10mm,探探时化脓,严重骨质流失。植体假体在手术前被移除以获得内固定。随后对缺损进行清创和种植体解毒,使用异种移植物和牙釉质基质衍生物的混合物来填补缺损。高密度聚四氟乙烯膜覆盖缺损。皮瓣被替换,没有尝试初级闭合,膜被故意暴露。结果:在20个月的随访中,疾病得到了明显的x线骨填充,并保持稳定。此外,术后角质化组织得到充分保存。结论:开放膜入路重建手术是治疗晚期种植体周围炎缺损的一种选择,具有保留角化组织和减少术中创伤的优点。重点:开放膜技术可以作为一种可行的替代方法,用于种植体周围重建手术的引导骨再生。优点包括减少手术创伤,缩短手术时间,保存角化组织。谨慎的病例选择对于实现可预测的结果至关重要。考虑的因素包括缺损的形态、剩余骨壁的数量和创口的大小。在更具挑战性的病例中,联合治疗和辅助使用生物制剂可以考虑增强再生潜力和改善临床结果。简单的语言总结:本案例研究介绍了使用开膜技术对种植体周围慢性炎症和骨质流失的再生治疗。为了控制这种情况,将种植体的冠部分移除,并彻底清洁和消毒种植体表面。然后用骨移植物和生物制剂填充种植体周围的空间,并用膜覆盖。与典型的再生手术不同,在愈合过程中,膜被故意部分暴露,而不是完全被牙龈覆盖。手术后,感染得到了解决,该区域保持健康长达20个月。这个病例表明,开放膜技术可能是治疗严重种植体感染的成功选择,特别是当目标是保护牙龈组织时。
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引用次数: 0
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Clinical Advances in Periodontics
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