Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study.

Cynthia M Stonnington, Janina Krell-Roesch, Dona E C Locke, Joseph G Hentz, Amylou C Dueck, Yonas E Geda, Pierre N Tariot, Richard J Caselli
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Abstract

Objective: To investigate the association of a 6-month Zumba intervention with cognition and quality of life among older cognitively unimpaired apolipoprotein ∊4 (APOE4) carrier and noncarrier women.

Methods: Fifty-three women were randomly assigned to either twice-weekly Zumba group classes or maintenance of habitual exercise (control group) for 6 months. At baseline, 3, and 6 months, all participants underwent neuropsychological, physical activity, and quality-of-life assessments.

Results: Overall, neuropsychological test scores and level of physical activity did not differ between intervention and control groups at any time. However, compared to the control group, quality of life was higher at 3 months, and visuospatial working memory and response inhibition improved more in the intervention group by 6 months. Apolipoprotein ∊4 status did not affect the results.

Discussion: Zumba may strengthen performance on visuospatial working memory among cognitively unimpaired older women but this needs to be tested in a larger clinical trial.

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尊巴对认知障碍老年妇女认知和生活质量的影响与APOE4携带者状态无关:一项为期6个月的随机对照试验研究。
目的:研究6个月Zumba干预与老年认知未受损载脂蛋白4(APOE4)携带者和非携带者的认知和生活质量的关系。方法:53名女性被随机分配到每周两次的尊巴组或持续6个月的习惯性锻炼(对照组)。在基线、3个月和6个月时,所有参与者都接受了神经心理、身体活动和生活质量评估。结果:总的来说,在任何时候,干预组和对照组的神经心理测试分数和体育活动水平都没有差异。然而,与对照组相比,干预组在3个月时生活质量更高,在6个月时视觉空间工作记忆和反应抑制改善更多。载脂蛋白∊4状态不影响结果。讨论:尊巴可能会增强认知未受损的老年女性在视觉空间工作记忆方面的表现,但这需要在更大规模的临床试验中进行测试。
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