NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis

IF 8.1 1区 生物学 Q1 PLANT SCIENCES New Phytologist Pub Date : 2023-10-02 DOI:10.1111/nph.19287
Bao Xie, Mingyu Luo, Qiuyi Li, Jing Shao, Desheng Chen, David E. Somers, Dingzhong Tang, Hua Shi
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在拟南芥中,NUA通过与ESD4协同去SUMO化TPR1来正向调节植物免疫。
核孔复合体(NPC)是由多个核孔蛋白(Nups)组成的。大量研究强调了NPC在植物免疫中的重要性。然而,人们对个别Nup的具体作用知之甚少。核孔锚(NUA)是NPC的组成部分。NUA的缺失导致拟南芥中SUMO偶联物的增加和多效性发育缺陷。在此,我们揭示了NUA是植物防御多种病原体所必需的。核孔锚与转录辅压因子TOPLESS-RELATED1(TPR1)结合,并有助于TPR1去SUMO化。值得注意的是,短日早期NUA相互作用蛋白4(ESD4),一种SUMO蛋白酶,特异性地去SUMO化TPR1。先前已经证实,SUMO E3连接酶SAP和MIZ1结构域含连接酶1(SIZ1)介导的TPR1的SUMO化抑制TPR1的免疫相关功能。与这一观点一致的是,nua-3中高度SUMO化的TPR1导致TPR1靶基因的表达上调,并损害了TPR1介导的抗病性。总之,我们的工作揭示了一种机制,通过该机制,NUA通过与ESD4协同作用来积极调节植物防御反应。我们的发现,以及之前的研究,揭示了一个调节模块,其中SIZ1和NUA/ESD4控制TPR1 SUMO化的稳态,以维持适当的免疫输出。
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来源期刊
New Phytologist
New Phytologist 生物-植物科学
自引率
5.30%
发文量
728
期刊介绍: New Phytologist is an international electronic journal published 24 times a year. It is owned by the New Phytologist Foundation, a non-profit-making charitable organization dedicated to promoting plant science. The journal publishes excellent, novel, rigorous, and timely research and scholarship in plant science and its applications. The articles cover topics in five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. These sections encompass intracellular processes, global environmental change, and encourage cross-disciplinary approaches. The journal recognizes the use of techniques from molecular and cell biology, functional genomics, modeling, and system-based approaches in plant science. Abstracting and Indexing Information for New Phytologist includes Academic Search, AgBiotech News & Information, Agroforestry Abstracts, Biochemistry & Biophysics Citation Index, Botanical Pesticides, CAB Abstracts®, Environment Index, Global Health, and Plant Breeding Abstracts, and others.
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