Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2023-11-01 DOI:10.1016/j.cis.2023.103002

Fezile Motsoene, Heidi Abrahamse, Sathish Sundar Dhilip Kumar

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Abstract

Wound healing primarily involves preventing severe infections, accelerating healing, and reducing pain and scarring. Therefore, the multifunctional application of lipid-based nanoparticles (LBNs) has received considerable attention in drug discovery due to their solid or liquid lipid core, which increases their ability to provide prolonged drug release, reduce treatment costs, and improve patient compliance. LBNs have also been used in medical and cosmetic practices and formulated for various products based on skin type, disease conditions, administration product costs, efficiency, stability, and toxicity; therefore, understanding their interaction with biological systems is very important. Therefore, it is necessary to perform an in-depth analysis of the results from a comprehensive characterization process to produce lipid-based drug delivery systems with desired properties. This review will provide detailed information on the different types of LBNs, their formulation methods, characterisation, antimicrobial activity, and application in various wound models (both in vitro and in vivo studies). Also, the clinical and commercial applications of LBNs are summarized.

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用于伤口愈合和抗菌应用的多功能脂质基纳米颗粒：综述。

伤口愈合主要包括预防严重感染、加速愈合、减少疼痛和疤痕。因此，基于脂质的纳米颗粒（LBN）的多功能应用在药物发现中受到了相当大的关注，因为它们的固体或液体脂质核心增加了它们提供延长药物释放、降低治疗成本和提高患者依从性的能力。LBN也已用于医疗和化妆品实践，并根据皮肤类型、疾病状况、给药产品成本、效率、稳定性和毒性为各种产品配制；因此，了解它们与生物系统的相互作用是非常重要的。因此，有必要对综合表征过程的结果进行深入分析，以生产具有所需性质的基于脂质的药物递送系统。这篇综述将提供关于不同类型LBN、它们的配方方法、表征、抗菌活性以及在各种伤口模型中的应用（体外和体内研究）的详细信息。并对LBN的临床和商业应用进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.