Environmental and Microbial Factors in Inflammatory Bowel Disease Model Establishment: A Review Partly through Mendelian Randomization.

IF 3.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gut and Liver Pub Date : 2024-05-15 Epub Date: 2023-10-10 DOI:10.5009/gnl230179
Zesheng Lin, Wenjing Luo, Kaijun Zhang, Shixue Dai
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Abstract

Inflammatory bowel disease (IBD) is a complex condition resulting from environmental, microbial, immunologic, and genetic factors. With the advancement of Mendelian randomization research in IBD, we have gained new insights into the relationship between these factors and IBD. Many animal models of IBD have been developed using different methods, but few studies have attempted to model IBD by combining environmental factors and microbial factors. In this review, we examine how environmental factors and microbial factors affect the development and progression of IBD, and how they interact with each other and with the intestinal microbiota. We also summarize the current methods for creating animal models of IBD and compare their advantages and disadvantages. Based on the latest findings from Mendelian randomization studies on the role of environmental factors in IBD, we discuss which environmental and microbial factors could be used to construct a more realistic and reliable IBD experimental model. We propose that animal models of IBD should consider both environmental and microbial factors to better mimic human IBD pathogenesis and to reveal the underlying mechanisms of IBD at the immune and genetic levels. We highlight the importance of environmental and microbial factors in IBD pathogenesis and offer new perspectives and suggestions for improving experimental animal modeling. Our goal is to create a model that closely resembles the clinical picture of IBD.

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炎症性肠病模型建立中的环境和微生物因素:部分通过孟德尔随机化的综述。
炎症性肠病(IBD)是一种由环境、微生物、免疫和遗传因素引起的复杂疾病。随着孟德尔随机化研究IBD的进展,我们对这些因素与IBD之间的关系有了新的认识。已经使用不同的方法开发了许多IBD动物模型,但很少有研究试图通过结合环境因素和微生物因素来建立IBD模型。在这篇综述中,我们研究了环境因素和微生物因素如何影响IBD的发展和进展,以及它们如何相互作用和与肠道微生物群相互作用。我们还总结了目前建立IBD动物模型的方法,并比较了它们的优缺点。基于孟德尔随机化研究中关于环境因素在IBD中作用的最新发现,我们讨论了哪些环境和微生物因素可以用来构建更现实、更可靠的IBD实验模型。我们建议IBD的动物模型应考虑环境和微生物因素,以更好地模拟人类IBD的发病机制,并在免疫和遗传水平上揭示IBD的潜在机制。我们强调了环境和微生物因素在IBD发病机制中的重要性,并为改进实验动物模型提供了新的视角和建议。我们的目标是创建一个与IBD临床情况非常相似的模型。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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